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7beta-Hydroxyrutaecarpine

CAS# 163815-35-8

7beta-Hydroxyrutaecarpine

Catalog No. BCN6500----Order now to get a substantial discount!

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7beta-Hydroxyrutaecarpine: 5mg $886 In Stock
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Quality Control of 7beta-Hydroxyrutaecarpine

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Chemical structure

7beta-Hydroxyrutaecarpine

3D structure

Chemical Properties of 7beta-Hydroxyrutaecarpine

Cas No. 163815-35-8 SDF Download SDF
PubChem ID 15225951 Appearance Powder
Formula C18H13N3O2 M.Wt 303.3
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES C1C(N2C(=NC3=CC=CC=C3C2=O)C4=C1C5=CC=CC=C5N4)O
Standard InChIKey DPDVXGJNOSVWGA-OAHLLOKOSA-N
Standard InChI InChI=1S/C18H13N3O2/c22-15-9-12-10-5-1-3-7-13(10)19-16(12)17-20-14-8-4-2-6-11(14)18(23)21(15)17/h1-8,15,19,22H,9H2/t15-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 7beta-Hydroxyrutaecarpine

The fruits of Euodia ruticarpa

Biological Activity of 7beta-Hydroxyrutaecarpine

Description7beta-Hydroxyrutaecarpine is a natural product from Euodia ruticarpa.

Protocol of 7beta-Hydroxyrutaecarpine

Structure Identification
Chinese Journal of Experimental Traditional Medical Formulae, 2016 (5) :45-53.

Chemical Components of Alkaloids from Euodiae Fructus and Their Anti-angiogenic Activities[Reference: WebLink]

To study the chemical constituents and their anti-angiogenic activities of the fruits of Evodia rutaecarpa.
METHODS AND RESULTS:
Compounds were isolated and purified by column chromatography using silica gel,Sephadex LH-20, ODS and semi-preparative HPLC. Their structures were identified on the basis of physicochemical properties and spectral data. The anti-angiogenic activities of compounds were evaluated using a zebrafish model. Result: Twenty compounds were isolated and identified from the fruits of E. rutaecarpa,including one degraded limonoids calodendrolide( 1),6 indole alkaloids,i. e. rutaecarpine( 2),evodiamine( 3),goshuyuamide-Ι( 4),N-formyldihydrorutaecarpine( 5),and 7beta-Hydroxyrutaecarpine( 6),11 quinolone alkaloids,i. e. 2-hydroxy-4-methoxy-3-( 3'-methyl-2'-butenyl)-quinoline( 7),1-methyl-2-nonyl-4( 1H)-quinolone( 8),1-methyl-2-decyl-4( 1H)-quinolone( 9),1-methyl-2-undecyl-4( 1H)-quinolone( 10),dihydroevocarpine( 11),1-methyl-2-pentadecenyl-4( 1H)-quinolone( 12),1-methyl-2- [( Z)-6-undecyl]-4( 1H)-quinolone( 13),evocarpine( 14),1-methyl-2- [( Z)-4-tridecyl]-4( 1H)-quinolone( 15),mixture of 1-methyl-2- [( Z)-10-pentadecenyl ]-4( 1H)-quinolone and 1-methyl-2- [( Z)-6-pentadecenyl]-4( 1H)-quinolone( 16),1-methyl-2- [( 6Z,9Z)-6,9-pentadecenyl]-4( 1H)-quinolone( 17),2 amides,i. e. N-methylanthranylamide( 18),acetamide( 19),and one sterol,i. e. β-sitosterol( 20).Compounds 1( 20 mg·L~(-1)),2( 0. 5 mg·L~(-1)),3( 5,10 μg·L~(-1)),4( 10 mg·L~(-1)),5( 50 mg·L~(-1)),10( 20 mg·L~(-1)),11( 50 mg·L~(-1)),16( 20 mg·L~(-1)),and 18( 50 mg·L~(-1)) showed anti-angiogenic effects on internode blood vessels of Zebrafish models.
CONCLUSIONS:
Compounds 1-18 were characteristic constituents of Euodiae Fructus,and compounds 1 and 7 were isolated from this plant for the first time. Compounds 1-5,10,11,16,and 18 showed anti-angiogenic effects on internode blood vessels of Zebrafish models.

7beta-Hydroxyrutaecarpine Dilution Calculator

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Preparing Stock Solutions of 7beta-Hydroxyrutaecarpine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2971 mL 16.4853 mL 32.9707 mL 65.9413 mL 82.4266 mL
5 mM 0.6594 mL 3.2971 mL 6.5941 mL 13.1883 mL 16.4853 mL
10 mM 0.3297 mL 1.6485 mL 3.2971 mL 6.5941 mL 8.2427 mL
50 mM 0.0659 mL 0.3297 mL 0.6594 mL 1.3188 mL 1.6485 mL
100 mM 0.033 mL 0.1649 mL 0.3297 mL 0.6594 mL 0.8243 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 7beta-Hydroxyrutaecarpine

Chemical Components of Alkaloids from Euodiae Fructus and Their Anti-angiogenic Activities

Chinese Journal of Experimental Traditional Medical Formulae, 2016 (5) :45-53.

To study the chemical constituents and their anti-angiogenic activities of the fruits of Evodia rutaecarpa. Method: Compounds were isolated and purified by column chromatography using silica gel,Sephadex LH-20, ODS and semi-preparative HPLC. Their structures were identified on the basis of physicochemical properties and spectral data. The anti-angiogenic activities of compounds were evaluated using a zebrafish model. Result: Twenty compounds were isolated and identified from the fruits of E. rutaecarpa,including one degraded limonoids calodendrolide( 1),6 indole alkaloids,i. e. rutaecarpine( 2),evodiamine( 3),goshuyuamide-Ι( 4),N-formyldihydrorutaecarpine( 5),and 7beta-Hydroxyrutaecarpine( 6),11 quinolone alkaloids,i. e. 2-hydroxy-4-methoxy-3-( 3'-methyl-2'-butenyl)-quinoline( 7),1-methyl-2-nonyl-4( 1H)-quinolone( 8),1-methyl-2-decyl-4( 1H)-quinolone( 9),1-methyl-2-undecyl-4( 1H)-quinolone( 10),dihydroevocarpine( 11),1-methyl-2-pentadecenyl-4( 1H)-quinolone( 12),1-methyl-2- [( Z)-6-undecyl]-4( 1H)-quinolone( 13),evocarpine( 14),1-methyl-2- [( Z)-4-tridecyl]-4( 1H)-quinolone( 15),mixture of 1-methyl-2- [( Z)-10-pentadecenyl ]-4( 1H)-quinolone and 1-methyl-2- [( Z)-6-pentadecenyl]-4( 1H)-quinolone( 16),1-methyl-2- [( 6Z,9Z)-6,9-pentadecenyl]-4( 1H)-quinolone( 17),2 amides,i. e. N-methylanthranylamide( 18),acetamide( 19),and one sterol,i. e. β-sitosterol( 20).

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