9-NitrocamptothecinCAS# 91421-42-0 |
Quality Control & MSDS
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| Cas No. | 91421-42-0 | SDF | Download SDF |
| PubChem ID | 472335 | Appearance | Yellow crystalline powder |
| Formula | C20H15N3O6 | M.Wt | 393.35 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Synonyms | 9-Nitrocellulose camptothecine;Rubitecan;86639-62-5 | ||
| Solubility | DMSO : 125 mg/mL (317.78 mM; Need ultrasonic) | ||
| SMILES | CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC=C(C5=C4)[N+](=O)[O-])O | ||
| Standard InChIKey | VHXNKPBCCMUMSW-FQEVSTJZSA-N | ||
| Standard InChI | InChI=1S/C20H15N3O6/c1-2-20(26)13-7-16-17-10(8-22(16)18(24)12(13)9-29-19(20)25)6-11-14(21-17)4-3-5-15(11)23(27)28/h3-7,26H,2,8-9H2,1H3/t20-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The barks of Camptotheca acuminata Decne.
| Description | 1. Rubitecan is a novel oral inhibitor of topoisomerase I in the camptothecin class. 2. Rubitecan shows antitumour activity in patients with refractory pancreatic cancer who have failed prior treatments. |
| Targets | Topoisomerase |
9-Nitrocamptothecin Dilution Calculator
9-Nitrocamptothecin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.5423 mL | 12.7113 mL | 25.4227 mL | 50.8453 mL | 63.5566 mL |
| 5 mM | 0.5085 mL | 2.5423 mL | 5.0845 mL | 10.1691 mL | 12.7113 mL |
| 10 mM | 0.2542 mL | 1.2711 mL | 2.5423 mL | 5.0845 mL | 6.3557 mL |
| 50 mM | 0.0508 mL | 0.2542 mL | 0.5085 mL | 1.0169 mL | 1.2711 mL |
| 100 mM | 0.0254 mL | 0.1271 mL | 0.2542 mL | 0.5085 mL | 0.6356 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells.
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