Bakkenolide IIIa

CAS# 915289-60-0

Bakkenolide IIIa

Catalog No. BCN7352----Order now to get a substantial discount!

Product Name & Size Price Stock
Bakkenolide IIIa: 5mg $989 In Stock
Bakkenolide IIIa: 10mg Please Inquire In Stock
Bakkenolide IIIa: 20mg Please Inquire Please Inquire
Bakkenolide IIIa: 50mg Please Inquire Please Inquire
Bakkenolide IIIa: 100mg Please Inquire Please Inquire
Bakkenolide IIIa: 200mg Please Inquire Please Inquire
Bakkenolide IIIa: 500mg Please Inquire Please Inquire
Bakkenolide IIIa: 1000mg Please Inquire Please Inquire

Quality Control of Bakkenolide IIIa

Number of papers citing our products

Chemical structure

Bakkenolide IIIa

3D structure

Chemical Properties of Bakkenolide IIIa

Cas No. 915289-60-0 SDF Download SDF
PubChem ID 125181677 Appearance Powder
Formula C24H32O6S M.Wt 448.57
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(1R,2R,3aR,4S,7S,7aR)-3a,4-dimethyl-4'-methylidene-7-[(Z)-3-methylsulfanylprop-2-enoyl]oxy-2'-oxospiro[3,4,5,6,7,7a-hexahydro-1H-indene-2,3'-oxolane]-1-yl] (Z)-2-methylbut-2-enoate
SMILES CC=C(C)C(=O)OC1C2C(CCC(C2(CC13C(=C)COC3=O)C)C)OC(=O)C=CSC
Standard InChIKey LWJFULOPSWJZSL-BZNVVBPTSA-N
Standard InChI InChI=1S/C24H32O6S/c1-7-14(2)21(26)30-20-19-17(29-18(25)10-11-31-6)9-8-15(3)23(19,5)13-24(20)16(4)12-28-22(24)27/h7,10-11,15,17,19-20H,4,8-9,12-13H2,1-3,5-6H3/b11-10-,14-7-/t15-,17-,19+,20+,23+,24+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Bakkenolide IIIa

The rhizomes of Petasites formosanus.

Biological Activity of Bakkenolide IIIa

Description1. Bakkenolide IIIa has neuroprotective effects, it protects against cerebral damage by inhibiting AKT and ERK1/2 activation and inactivated NF-κB signaling. 2. Bakkenolide IIIa shows antioxidant activity.
TargetsAkt | Bcl-2/Bax | p65 | NF-kB | IkB | ERK | IKK

Bakkenolide IIIa Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Bakkenolide IIIa Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Bakkenolide IIIa

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2293 mL 11.1465 mL 22.2931 mL 44.5861 mL 55.7327 mL
5 mM 0.4459 mL 2.2293 mL 4.4586 mL 8.9172 mL 11.1465 mL
10 mM 0.2229 mL 1.1147 mL 2.2293 mL 4.4586 mL 5.5733 mL
50 mM 0.0446 mL 0.2229 mL 0.4459 mL 0.8917 mL 1.1147 mL
100 mM 0.0223 mL 0.1115 mL 0.2229 mL 0.4459 mL 0.5573 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Bakkenolide IIIa

Bakkenolide-IIIa Protects Against Cerebral Damage Via Inhibiting NF-kappaB Activation.[Pubmed:26511680]

CNS Neurosci Ther. 2015 Dec;21(12):943-52.

AIMS: This study was designed to examine the neuroprotective effects of bakkenolide-IIIa, a major novel compound extracted from the rhizome of P. trichinous. METHODS: Transient focal cerebral damage model in rats and oxygen-glucose deprivation (OGD) in cultured hippocampal neurons were performed. The amount of apoptotic neurons was determined using TUNEL assay. The expressions of Bcl-2, Bax, Akt, ERK1/2, IKKbeta, IkappaBalpha were measured using Western blot. The nuclear translocation and activation of NF-kappaB was measured using a fluorescence microscope and electrophoretic mobility shift assay (EMSA). RESULTS: Bakkenolide-IIIa (4, 8, 16 mg/kg; i.g.) was administered immediately after reperfusion could reduce the brain infarct volume, and the neurological deficit, as well as a high dose of bakkenolide-IIIa, increases the 72 h survival rate in cerebrally damaged rats. In vitro data demonstrated that bakkenolide-IIIa could increase cell viability and decrease the amount of apoptotic cells in cultured primary hippocampal neurons exposed to OGD. Bakkenolide-IIIa also dose-dependently increased the ratio of Bcl-2 to Bax. These results indicated that inhibition of apoptosis partly mediated the neuroprotection of bakkenolide-IIIa. Furthermore, bakkenolide-IIIa inhibited the phosphorylation of Akt, ERK1/2, IKKbeta, IkappaBalpha, and p65 in cultured hippocampal neurons exposed to OGD. Bakkenolide-IIIa not only inhibited the nuclear translocation of NF-kappaB in cultured neurons exposed to OGD, but also inhibited the activation of NF-kappaB in peri-infarct area in cerebrally damaged rats. CONCLUSION: Collectively, our findings indicated that bakkenolide-IIIa protects against cerebral damage by inhibiting AKT and ERK1/2 activation and inactivated NF-kappaB signaling.

Bakkenolides from Petasites tricholobus and their neuroprotective effects related to antioxidant activities.[Pubmed:19085813]

Planta Med. 2009 Feb;75(3):230-5.

Four novel bakkenolides - bakkenolide-Ia ( 1), bakkenolide-IIa ( 2), bakkenolide-IIIa ( 3) and bakkenolide-IVa ( 4) - were isolated from the extract of the rhizome of Petasites tricholobus. The structures were characterized by using NMR ( (1)H, (13)C, (1)H- (1)H COSY, HMQC, HMBC, and NOESY) and mass spectrometry. The neuroprotective activity of the compounds 1 - 4 was assayed with primary cultured neurons exposed to oxygen-glucose deprivation and oxidative insults. Antioxidant activity of the bakkenolides was evaluated by cell-free bioassays. The IN VITRO assay results showed that all these compounds exhibited significant neuroprotective and antioxidant activities. To our knowledge, this is the first report on the neuroprotective and antioxidant activities of bakkenolides.

Keywords:

Bakkenolide IIIa,915289-60-0,Natural Products, buy Bakkenolide IIIa , Bakkenolide IIIa supplier , purchase Bakkenolide IIIa , Bakkenolide IIIa cost , Bakkenolide IIIa manufacturer , order Bakkenolide IIIa , high purity Bakkenolide IIIa

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: