Acetylcimigenol 3-O-alpha-L-arabinopyransideCAS# 402513-88-6 |
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| Cas No. | 402513-88-6 | SDF | Download SDF |
| PubChem ID | 10865257 | Appearance | Powder |
| Formula | C37H58O10 | M.Wt | 662.9 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC(CC(C1C(O1)(C)C)OC(=O)C)C2C(=O)C(C3(C2(CCC45C3CCC6C4(C5)CCC(C6(C)C)OC7C(C(C(CO7)O)O)O)C)C)O | ||
| Standard InChIKey | IHEJMZHKJYHVFF-NETQQFODSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The roots of Cimicifuga foetida L.
Acetylcimigenol 3-O-alpha-L-arabinopyranside Dilution Calculator
Acetylcimigenol 3-O-alpha-L-arabinopyranside Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.5085 mL | 7.5426 mL | 15.0852 mL | 30.1705 mL | 37.7131 mL |
| 5 mM | 0.3017 mL | 1.5085 mL | 3.017 mL | 6.0341 mL | 7.5426 mL |
| 10 mM | 0.1509 mL | 0.7543 mL | 1.5085 mL | 3.017 mL | 3.7713 mL |
| 50 mM | 0.0302 mL | 0.1509 mL | 0.3017 mL | 0.6034 mL | 0.7543 mL |
| 100 mM | 0.0151 mL | 0.0754 mL | 0.1509 mL | 0.3017 mL | 0.3771 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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[Cytotoxicity and mechanism of 23-O-acetylcimigenol-3-O-beta-D-xylopyranoside on HepG2 cells].[Pubmed:17260803]
Zhongguo Zhong Yao Za Zhi. 2006 Nov;31(21):1818-21.
OBJECTIVE: To elucidate the cytotoxicity and mechanism of 23-O-acetylcimigenol-3-O-beta-D-xylopyranoside isolated from C. dahurica on HepG2 cells and to find the leading compound for new drug development. METHOD: MTT, AO/EB staining observation, flow cytometry and western blot methods were used to study the cytotoxicity, morphological changes, cell cycle distribution and protein expression profile of 23-O-acetylcimigenol-3-O-beta-D-xylopyranoside on HepG2 cells. RESULT: 23-O-acetylcimigenol-3-O-beta-D-xylopyranoside could inhibit the proliferation of HepG2 cells with IC50 at 16 micromol x L(-1), and could also induce apoptosis and G2-M cell cycle arrest. Further study demonstrated that the compound could cleavage PARP, regulate protein expression of bcl-2 family and decrease the expression of cdc 2 and cyclin B. CONCLUSION: 23-O-acetylcimigenol-3-O-beta-D-xylopyranoside exerts its cytotoxicity on HepG2 cells via apoptosis and G2-M arrest. In addition, caspases family activation, regulation of protein expression of bcl-2 family and down regulation of cdc 2 and cyclin B were involved in apoptosis and G2-M arrest induced by it.
Acetylshengmanol Arabinoside is isolated from Cimicifugae rhizoma.
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