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Deacetylcinobufagin

CAS# 4026-95-3

Deacetylcinobufagin

Catalog No. BCN2720----Order now to get a substantial discount!

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Quality Control of Deacetylcinobufagin

Number of papers citing our products

Chemical structure

Deacetylcinobufagin

3D structure

Chemical Properties of Deacetylcinobufagin

Cas No. 4026-95-3 SDF Download SDF
PubChem ID 314718 Appearance Powder
Formula C24H32O5 M.Wt 400.52
Type of Compound Steroids Storage Desiccate at -20°C
Synonyms Deacetylcinobufagin
Solubility DMSO : ≥ 26 mg/mL (64.92 mM)
*"≥" means soluble, but saturation unknown.
SMILES CC12CCC(CC1CCC3C2CCC4(C35C(O5)C(C4C6=COC(=O)C=C6)O)C)O
Standard InChIKey IXZHDDUFQVXHIL-UHFFFAOYSA-N
Standard InChI InChI=1S/C24H32O5/c1-22-9-7-15(25)11-14(22)4-5-17-16(22)8-10-23(2)19(13-3-6-18(26)28-12-13)20(27)21-24(17,23)29-21/h3,6,12,14-17,19-21,25,27H,4-5,7-11H2,1-2H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Deacetylcinobufagin

The glandular body of Bufo bufo gargarizans Cantor

Biological Activity of Deacetylcinobufagin

DescriptionDeacetylcinobufagin shows the potent activities against human carcinoma cervicis (Hela) and malignant melanoma (A375) cells in vitro.
In vitro

Efficient isolation and purification of five products from microbial biotransformation of cinobufagin by high-speed counter-current chromatography.[Pubmed: 20574960]

J Sep Sci. 2010 Aug;33(15):2272-7.


METHODS AND RESULTS:
An efficient separation method of using high-speed counter-current chromatography was successfully established to directly purify cytotoxic transformed products of cinobufagin by Cordyceps militaris. The two-phase solvent system composed of n-hexane-ethyl acetate-methanol-water (4:6:3:4, v/v) was used in high-speed counter-current chromatography. A total of 9 mg of 4beta,12alpha-dihydroxyl-cinobufagin (1), 15 mg of 12beta-hydroxyl-cinobufagin (2), 8 mg of 5beta-hydroxyl-cinobufagin (3), 12 mg of Deacetylcinobufagin (4) and 6 mg of 3-keto-cinobufagin (5) were obtained in a one-step separation from 400 mg of the crude extract with purity of 98.7, 97.2, 90.6, 99.1 and 99.4%, respectively, as determined by HPLC. Their chemical structures were identified on the basis of (1)H-NMR and (13)C-NMR technology.
CONCLUSIONS:
All products (1-5) showed the potent activities against human carcinoma cervicis (Hela) and malignant melanoma (A375) cells in vitro.

Deacetylcinobufagin Dilution Calculator

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Deacetylcinobufagin Molarity Calculator

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Preparing Stock Solutions of Deacetylcinobufagin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4968 mL 12.4838 mL 24.9675 mL 49.9351 mL 62.4189 mL
5 mM 0.4994 mL 2.4968 mL 4.9935 mL 9.987 mL 12.4838 mL
10 mM 0.2497 mL 1.2484 mL 2.4968 mL 4.9935 mL 6.2419 mL
50 mM 0.0499 mL 0.2497 mL 0.4994 mL 0.9987 mL 1.2484 mL
100 mM 0.025 mL 0.1248 mL 0.2497 mL 0.4994 mL 0.6242 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Deacetylcinobufagin

Desacetylcinobufagin is a natural compound used for microbial transformation.

References:
[1]. Zhu ZT, et al. Novel microbial transformation of desacetylcinobufagin by Fusarium avenaceum AS 3.4594. J Asian Nat Prod Res. 2013;15(3):294-9.

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References on Deacetylcinobufagin

Efficient isolation and purification of five products from microbial biotransformation of cinobufagin by high-speed counter-current chromatography.[Pubmed:20574960]

J Sep Sci. 2010 Aug;33(15):2272-7.

An efficient separation method of using high-speed counter-current chromatography was successfully established to directly purify cytotoxic transformed products of cinobufagin by Cordyceps militaris. The two-phase solvent system composed of n-hexane-ethyl acetate-methanol-water (4:6:3:4, v/v) was used in high-speed counter-current chromatography. A total of 9 mg of 4beta,12alpha-dihydroxyl-cinobufagin (1), 15 mg of 12beta-hydroxyl-cinobufagin (2), 8 mg of 5beta-hydroxyl-cinobufagin (3), 12 mg of Deacetylcinobufagin (4) and 6 mg of 3-keto-cinobufagin (5) were obtained in a one-step separation from 400 mg of the crude extract with purity of 98.7, 97.2, 90.6, 99.1 and 99.4%, respectively, as determined by HPLC. Their chemical structures were identified on the basis of (1)H-NMR and (13)C-NMR technology. All products (1-5) showed the potent activities against human carcinoma cervicis (Hela) and malignant melanoma (A375) cells in vitro.

Description

Desacetylcinobufagin is a natural compound used for microbial transformation.

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