DeacetylcinobufaginCAS# 4026-95-3 |
Quality Control & MSDS
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| Cas No. | 4026-95-3 | SDF | Download SDF |
| PubChem ID | 314718 | Appearance | Powder |
| Formula | C24H32O5 | M.Wt | 400.52 |
| Type of Compound | Steroids | Storage | Desiccate at -20°C |
| Synonyms | Deacetylcinobufagin | ||
| Solubility | DMSO : ≥ 26 mg/mL (64.92 mM) *"≥" means soluble, but saturation unknown. | ||
| SMILES | CC12CCC(CC1CCC3C2CCC4(C35C(O5)C(C4C6=COC(=O)C=C6)O)C)O | ||
| Standard InChIKey | IXZHDDUFQVXHIL-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C24H32O5/c1-22-9-7-15(25)11-14(22)4-5-17-16(22)8-10-23(2)19(13-3-6-18(26)28-12-13)20(27)21-24(17,23)29-21/h3,6,12,14-17,19-21,25,27H,4-5,7-11H2,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Deacetylcinobufagin shows the potent activities against human carcinoma cervicis (Hela) and malignant melanoma (A375) cells in vitro. |
| In vitro | Efficient isolation and purification of five products from microbial biotransformation of cinobufagin by high-speed counter-current chromatography.[Pubmed: 20574960]J Sep Sci. 2010 Aug;33(15):2272-7.
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Deacetylcinobufagin Dilution Calculator
Deacetylcinobufagin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.4968 mL | 12.4838 mL | 24.9675 mL | 49.9351 mL | 62.4189 mL |
| 5 mM | 0.4994 mL | 2.4968 mL | 4.9935 mL | 9.987 mL | 12.4838 mL |
| 10 mM | 0.2497 mL | 1.2484 mL | 2.4968 mL | 4.9935 mL | 6.2419 mL |
| 50 mM | 0.0499 mL | 0.2497 mL | 0.4994 mL | 0.9987 mL | 1.2484 mL |
| 100 mM | 0.025 mL | 0.1248 mL | 0.2497 mL | 0.4994 mL | 0.6242 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Desacetylcinobufagin is a natural compound used for microbial transformation.
References:
[1]. Zhu ZT, et al. Novel microbial transformation of desacetylcinobufagin by Fusarium avenaceum AS 3.4594. J Asian Nat Prod Res. 2013;15(3):294-9.
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Efficient isolation and purification of five products from microbial biotransformation of cinobufagin by high-speed counter-current chromatography.[Pubmed:20574960]
J Sep Sci. 2010 Aug;33(15):2272-7.
An efficient separation method of using high-speed counter-current chromatography was successfully established to directly purify cytotoxic transformed products of cinobufagin by Cordyceps militaris. The two-phase solvent system composed of n-hexane-ethyl acetate-methanol-water (4:6:3:4, v/v) was used in high-speed counter-current chromatography. A total of 9 mg of 4beta,12alpha-dihydroxyl-cinobufagin (1), 15 mg of 12beta-hydroxyl-cinobufagin (2), 8 mg of 5beta-hydroxyl-cinobufagin (3), 12 mg of Deacetylcinobufagin (4) and 6 mg of 3-keto-cinobufagin (5) were obtained in a one-step separation from 400 mg of the crude extract with purity of 98.7, 97.2, 90.6, 99.1 and 99.4%, respectively, as determined by HPLC. Their chemical structures were identified on the basis of (1)H-NMR and (13)C-NMR technology. All products (1-5) showed the potent activities against human carcinoma cervicis (Hela) and malignant melanoma (A375) cells in vitro.
