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23-O-Acetylshengmanol 3-O-beta-D-xyloside

CAS# 62498-88-8

23-O-Acetylshengmanol 3-O-beta-D-xyloside

Catalog No. BCN7947----Order now to get a substantial discount!

Product Name & Size Price Stock
23-O-Acetylshengmanol 3-O-beta-D-xyloside: 5mg Please Inquire In Stock
23-O-Acetylshengmanol 3-O-beta-D-xyloside: 10mg Please Inquire In Stock
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23-O-Acetylshengmanol 3-O-beta-D-xyloside: 50mg Please Inquire Please Inquire
23-O-Acetylshengmanol 3-O-beta-D-xyloside: 100mg Please Inquire Please Inquire
23-O-Acetylshengmanol 3-O-beta-D-xyloside: 200mg Please Inquire Please Inquire
23-O-Acetylshengmanol 3-O-beta-D-xyloside: 500mg Please Inquire Please Inquire
23-O-Acetylshengmanol 3-O-beta-D-xyloside: 1000mg Please Inquire Please Inquire
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Quality Control of 23-O-Acetylshengmanol 3-O-beta-D-xyloside

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Chemical structure

23-O-Acetylshengmanol 3-O-beta-D-xyloside

3D structure

Chemical Properties of 23-O-Acetylshengmanol 3-O-beta-D-xyloside

Cas No. 62498-88-8 SDF Download SDF
PubChem ID 56962372 Appearance Powder
Formula C37H58O10 M.Wt 662.85
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC(CC(C1C(O1)(C)C)OC(=O)C)C2C(=O)C(C3(C2(CCC45C3CCC6C4(C5)CCC(C6(C)C)OC7C(C(C(CO7)O)O)O)C)C)O
Standard InChIKey IHEJMZHKJYHVFF-JUKRZFGDSA-N
Standard InChI InChI=1S/C37H58O10/c1-18(15-21(45-19(2)38)30-33(5,6)47-30)25-27(41)29(43)35(8)23-10-9-22-32(3,4)24(46-31-28(42)26(40)20(39)16-44-31)11-12-36(22)17-37(23,36)14-13-34(25,35)7/h18,20-26,28-31,39-40,42-43H,9-17H2,1-8H3/t18-,20-,21-,22+,23+,24+,25+,26+,28-,29+,30+,31+,34-,35-,36-,37+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 23-O-Acetylshengmanol 3-O-beta-D-xyloside

The herbs of Curculigo orchioides

Biological Activity of 23-O-Acetylshengmanol 3-O-beta-D-xyloside

Description23-O-Actylshengmanol-3-xyloside selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2, PI3K, and PKC are involved in this effect.
TargetsTNF-α | PPAR-γ | ERK | PI3K | PKC
In vitro

Isoimperatorin, cimiside E and 23-O-acetylshengmanol-3-xyloside from Cimicifugae Rhizome inhibit TNF-α-induced VCAM-1 expression in human endothelial cells: Involvement of PPAR-γ upregulation and PI3K, ERK1/2, and PKC signal pathways.[Reference: WebLink]

Journal of Ethnopharmacology, 2011, 133(2):0-344.

The methanol extract of Cimicifugae Rhizome has been traditionally used in various disorders including inflammation.
METHODS AND RESULTS:
The aim of the study is to explore whether anti-inflammatory action of 3 active compounds, two triterpenoid glycosides (cimiside E, 23-O-actylshengmanol-3-xyloside(23-O-Acetylshengmanol 3-O-beta-D-xyloside)) and one furanocoumarin (isoimperatorin), isolated from Cimicifugae Rhizome is related with peroxisome proliferator-activated receptor-γ (PPAR-γ) expression in human umbilical endothelial cell line, EA.hy926 cells. Cell viability and production of reactive oxygen species were performed. In addition, adhesion of monocyte into endothelial cells and western blot for expression of adhesion molecules and signal proteins were investigated in tumor necrosis factor-α (TNF-α)-activated cells. Pretreatment of test compounds significantly reduced reactive oxygen species (ROS) production and expression of vascular cell adhesion molecule-1 (VCAM-1), but not intercellular cell adhesion molecule-1 (ICAM-1). Three compounds all dose-dependently increased not only PPAR-γ expression in EA.hy926 cells but inhibited TNF-α-induced phosphorylation of Akt, extracellular-signal-regulated kinase (ERK) and protein kinase C (PKC) with different specificity. Finally, they prevented TNF-α-induced adhesion of U937 monocytic cells to EA.hy926 cells.
CONCLUSIONS:
The present results show that cimiside E, 23-O-actylshengmanol-3-xyloside, isoimperatorin isolated from Cimicifugae Rhizome selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2, PI3K, and PKC are involved in this effect.

23-O-Acetylshengmanol 3-O-beta-D-xyloside Dilution Calculator

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23-O-Acetylshengmanol 3-O-beta-D-xyloside Molarity Calculator

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Preparing Stock Solutions of 23-O-Acetylshengmanol 3-O-beta-D-xyloside

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.5086 mL 7.5432 mL 15.0864 mL 30.1727 mL 37.7159 mL
5 mM 0.3017 mL 1.5086 mL 3.0173 mL 6.0345 mL 7.5432 mL
10 mM 0.1509 mL 0.7543 mL 1.5086 mL 3.0173 mL 3.7716 mL
50 mM 0.0302 mL 0.1509 mL 0.3017 mL 0.6035 mL 0.7543 mL
100 mM 0.0151 mL 0.0754 mL 0.1509 mL 0.3017 mL 0.3772 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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