3-Hydroxybutyric acidCAS# 625-71-8 |
Quality Control & MSDS
3D structure
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| Cas No. | 625-71-8 | SDF | Download SDF |
| PubChem ID | 441 | Appearance | Cryst. |
| Formula | C4H8O3 | M.Wt | 104.1 |
| Type of Compound | Miscellaneous | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 3-hydroxybutanoic acid | ||
| SMILES | CC(CC(=O)O)O | ||
| Standard InChIKey | WHBMMWSBFZVSSR-UHFFFAOYSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 3-Hydroxybutyric acid is a ketone body and acts as an indicator of energy balance and a central regulator of energy homeostasis. 3-Hydroxybutyric acid has anesthetic actions, which are due to the metabolite's abilities to alter physical properties of cell membranes, leading to indirect effects on membrane protein function. |
| In vitro | Enzymatic fluorometric microplate assay for quantitative analysis of 3-hydroxybutyric acid in mouse plasma.[Pubmed: 22449496]Anal Biochem. 2012 Jun 15;425(2):114-6.3-Hydroxybutyric acid (3HB) is a ketone body and acts as an indicator of energy balance and a central regulator of energy homeostasis. |
| Structure Identification | Langmuir. 2013 Feb 12;29(6):1948-55.3-Hydroxybutyric acid interacts with lipid monolayers at concentrations that impair consciousness.[Pubmed: 23339286]
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3-Hydroxybutyric acid Dilution Calculator
3-Hydroxybutyric acid Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 9.6061 mL | 48.0307 mL | 96.0615 mL | 192.123 mL | 240.1537 mL |
| 5 mM | 1.9212 mL | 9.6061 mL | 19.2123 mL | 38.4246 mL | 48.0307 mL |
| 10 mM | 0.9606 mL | 4.8031 mL | 9.6061 mL | 19.2123 mL | 24.0154 mL |
| 50 mM | 0.1921 mL | 0.9606 mL | 1.9212 mL | 3.8425 mL | 4.8031 mL |
| 100 mM | 0.0961 mL | 0.4803 mL | 0.9606 mL | 1.9212 mL | 2.4015 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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3-Hydroxybutyric acid interacts with lipid monolayers at concentrations that impair consciousness.[Pubmed:23339286]
Langmuir. 2013 Feb 12;29(6):1948-55.
3-Hydroxybutyric acid (also referred to as beta-hydroxybutyric acid or BHB), a small molecule metabolite whose concentration is elevated in type I diabetes and diabetic coma, was found to modulate the properties of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) monolayers when added to the subphase at clinical concentrations. This is a key piece of evidence supporting the hypothesis that the anesthetic actions of BHB are due to the metabolite's abilities to alter physical properties of cell membranes, leading to indirect effects on membrane protein function. Pressure-area isotherms show that BHB changes the compressibility of the monolayer and decrease the size of the two-phase coexistence region. Epi-fluorescent microscopy further reveals that the reduction of the coexistence region is due to the significant reduction in morphology of the liquid condensed domains in the two-phase coexistence region. These changes in monolayer morphology are associated with the diminished interfacial viscosity of the monolayers (measured using an interfacial stress rheometer), which gives insight as to how changes in phase and structure may contribute to membrane function.
Enzymatic fluorometric microplate assay for quantitative analysis of 3-hydroxybutyric acid in mouse plasma.[Pubmed:22449496]
Anal Biochem. 2012 Jun 15;425(2):114-6.
3-Hydroxybutyric acid (3HB) is a ketone body and acts as an indicator of energy balance and a central regulator of energy homeostasis. We report the application of a sensitive fluorometric assay for the quantitative determination of 3HB. The assay is based on the oxidation of 3HB by 3HB dehydrogenase and on the diaphorase-resazurin amplifying system. This simple assay enables the measurement of changes in 3HB levels in the blood of normal mice by very small volume sample collection. Therefore, this assay will be useful for in vivo studies of small animals.
