Ajmalidine

CAS# 639-30-5

Ajmalidine

Catalog No. BCN3491----Order now to get a substantial discount!

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Quality Control of Ajmalidine

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Chemical structure

Ajmalidine

3D structure

Chemical Properties of Ajmalidine

Cas No. 639-30-5 SDF Download SDF
PubChem ID 21724884 Appearance Powder
Formula C20H24N2O2 M.Wt 324.4
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (1R,9R,10S,12S,13S,14R,16S)-13-ethyl-14-hydroxy-8-methyl-8,15-diazahexacyclo[14.2.1.01,9.02,7.010,15.012,17]nonadeca-2,4,6-trien-18-one
SMILES CCC1C2CC3C4C5(CC(C2C5=O)N3C1O)C6=CC=CC=C6N4C
Standard InChIKey JLUFXYAXVHAFTF-YNSIMGNASA-N
Standard InChI InChI=1S/C20H24N2O2/c1-3-10-11-8-14-17-20(12-6-4-5-7-13(12)21(17)2)9-15(16(11)18(20)23)22(14)19(10)24/h4-7,10-11,14-17,19,24H,3,8-9H2,1-2H3/t10-,11-,14-,15-,16?,17-,19+,20+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Ajmalidine

The root of Rauvolfia verticillata

Biological Activity of Ajmalidine

DescriptionStandard reference

Protocol of Ajmalidine

Structure Identification
Tetrahedron.1957;1(4):328-337.

Alkaloid studies–XIX: Alkaloids of some Hawaiian Rauwolfia species: The structure of sandwicine and its interconversion with ajmaline and ajmalidine.[Reference: WebLink]


METHODS AND RESULTS:
The alkaloid composition of the following three Hawaiian Rauwolfia species–R. sandwicensis A.DC., R. degeneri Sherff and R. mauiensis Sheriff–was determined. Aside from the known aklakoids serpentinine, ajmaline, tetraphylline and tetraphyllicine there were encountered trace amounts of two new dihydroindole alkaloids, mauiensine and sandwicensine as well as larger quantities of an isomer of ajmaline, which was named sandwicine (C20H26N2O2). Since sandwicine and ajmaline yield different dihydro derivatives which are convertible by lead tetra-acetate oxidation to a common indole hemi-acetal, sandwicine represents the C-17 epimer of ajmaline.
CONCLUSIONS:
Dihydrosandwicine was found to be identical with tetrahydroAjmalidine, the sodium borohydride reduction product of Ajmalidine, thereby proving that Ajmalidine is 17-dehydroajmaline.

Joint Malaysia-UK Symposium on Natural Product Chemistry and Drug Discovery. 2014.

Distribution of indole alkaloids in Indian Rauvolfia species.[Reference: WebLink]


METHODS AND RESULTS:
The major alkaloid distributed in the Rauvolfia species endemic to India (R. hookeri and R. micrantha) was identified as reserpiline by NMR studies of the compound isolated by column chromatography of the alkaloid extract. Further, reserpiline with Rf value close to reserpine, has been identified as a compound that can interfere in the HPTLC and HPLC estimation of reserpine. Other indole alkaloids ajmalicine, Ajmalidine, ajmaline, alstonine, deserpidine, sarpagine, tetraphylline, vomilinine and yohimbinic acid were identified by LC-Q-ToF-MS studies 3-4. HPTLC profiling using the marker compounds reserpine, reserpiline and ajmalicine showed close resemblance of the Indian endemic species R. hookeri and R. micrantha.
CONCLUSIONS:
This is the first report of the comparative phytochemical profiling of all the Rauvolfia species in India and the fingerprints will be much useful for the herbal drug industries for quality control measures.

Ajmalidine Dilution Calculator

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Ajmalidine Molarity Calculator

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Preparing Stock Solutions of Ajmalidine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0826 mL 15.4131 mL 30.8261 mL 61.6523 mL 77.0654 mL
5 mM 0.6165 mL 3.0826 mL 6.1652 mL 12.3305 mL 15.4131 mL
10 mM 0.3083 mL 1.5413 mL 3.0826 mL 6.1652 mL 7.7065 mL
50 mM 0.0617 mL 0.3083 mL 0.6165 mL 1.233 mL 1.5413 mL
100 mM 0.0308 mL 0.1541 mL 0.3083 mL 0.6165 mL 0.7707 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Ajmalidine

Alkaloid studies–XIX: Alkaloids of some Hawaiian Rauwolfia species: The structure of sandwicine and its interconversion with ajmaline and ajmalidine.

Tetrahedron.1957;1(4):328-337.

Since sandwicine and ajmaline yield different dihydro derivatives which are convertible by lead tetra-acetate oxidation to a common indole hemi-acetal, sandwicine represents the C-17 epimer of ajmaline. Dihydrosandwicine was found to be identical with tetrahydroAjmalidine, the sodium borohydride reduction product of Ajmalidine, thereby proving that Ajmalidine is 17-dehydroajmaline.

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