Anabasamine

CAS# 20410-87-1

Anabasamine

Catalog No. BCN2148----Order now to get a substantial discount!

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Quality Control of Anabasamine

Number of papers citing our products

Chemical structure

Anabasamine

3D structure

Chemical Properties of Anabasamine

Cas No. 20410-87-1 SDF Download SDF
PubChem ID 161313 Appearance Powder
Formula C16H19N3 M.Wt 253.35
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 5-(1-methylpiperidin-2-yl)-2-pyridin-3-ylpyridine
SMILES CN1CCCCC1C2=CN=C(C=C2)C3=CN=CC=C3
Standard InChIKey TZRDBHMKTWECOV-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Protocol of Anabasamine

Structure Identification
Tetrahedron Volume 39, Issue 1, 1983, Pages 41-47

Steroidal alkaloids (batrachotoxins and 4β-hydroxybatrachotoxins), “indole alkaloids” (calycanthine and chimonanthine) and a piperidinyldipyridin[Reference: WebLink]


METHODS AND RESULTS:
Skin extracts from the Colombian poison-dan frog Phytlobates terribilis contain three major steroidal alkaloids; Batrachotoxin, homobatrachotoxin and batrachotoxinin A. Minor congeners of batrachotoxin and homobalrachotoxin containing a 4β-OH substituent are identified based on mass spectra and proton and carbon-13 NMR.
CONCLUSIONS:
Two “indole alkaloids” 1-calycanthine and d-chimonanthine, enantiomeric to the same compounds from plants, and norAnabasamine (5-(2-piperidyl)2,3'-dipyridine), a des-N-Me analog of the plant alkaloid Anabasamine, are present as minor constituents.

J Asian Nat Prod Res. 2008 Nov-Dec;10(11-12):1093-5.

Alkaloids from Anabasis aphylla L.[Pubmed: 19031252 ]


METHODS AND RESULTS:
A new pyridine alkaloid 1, together with three known alkaloids N-methylanabasine (2), Anabasamine (3), and isonicoteine (4), was isolated from the aerial part of Anabasis aphylla L. Their structures were elucidated by spectroscopic analysis.

Anabasamine Dilution Calculator

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Anabasamine Molarity Calculator

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Preparing Stock Solutions of Anabasamine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.9471 mL 19.7355 mL 39.4711 mL 78.9422 mL 98.6777 mL
5 mM 0.7894 mL 3.9471 mL 7.8942 mL 15.7884 mL 19.7355 mL
10 mM 0.3947 mL 1.9736 mL 3.9471 mL 7.8942 mL 9.8678 mL
50 mM 0.0789 mL 0.3947 mL 0.7894 mL 1.5788 mL 1.9736 mL
100 mM 0.0395 mL 0.1974 mL 0.3947 mL 0.7894 mL 0.9868 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Anabasamine

Alkaloids from Anabasis aphylla L.[Pubmed:19031252]

J Asian Nat Prod Res. 2008 Nov-Dec;10(11-12):1093-5.

A new pyridine alkaloid 1, together with three known alkaloids N-methylanabasine (2), Anabasamine (3), and isonicoteine (4), was isolated from the aerial part of Anabasis aphylla L. Their structures were elucidated by spectroscopic analysis.

[Inhibiting effect of anabasine, anabasamine and lupinine alkaloids on ethanol action in mice].[Pubmed:624390]

Farmakol Toksikol. 1978 Jan-Feb;41(1):52-5.

Anabisis aphylla alcaloids anabasine, Anabasamine and lupinine (1/6 and 1/3) DL50, intraperitoneally) lowered the locomotion excitation called forth by aethanol (2 mg/g, by mouth) in mice. Lupinine shortened roughly by a foctor of 3 also the duration of aethanol anesthesia. The reduced excitation was attended by falling a blood aethanol concentration, while shortening of the anesthesia period was not, this suggesting different mechanisms in two disclosed antialcoholic effects of the alcaloids.

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