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Arecaidine hydrochloride

CAS# 6018-28-6

Arecaidine hydrochloride

Catalog No. BCN8530----Order now to get a substantial discount!

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Quality Control of Arecaidine hydrochloride

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Chemical structure

Arecaidine hydrochloride

3D structure

Chemical Properties of Arecaidine hydrochloride

Cas No. 6018-28-6 SDF Download SDF
PubChem ID 12305194 Appearance Powder
Formula C7H12ClNO2 M.Wt 177.63
Type of Compound Alkaloids Storage Desiccate at -20°C
Synonyms N-Methylguvacine hydrochloride
Solubility Soluble in ethanol and water; slightly soluble in chloroform and diethyl ether
Chemical Name 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid;hydrochloride
SMILES CN1CCC=C(C1)C(=O)O.Cl
Standard InChIKey PIVDNPNYIBGXPL-UHFFFAOYSA-N
Standard InChI InChI=1S/C7H11NO2.ClH/c1-8-4-2-3-6(5-8)7(9)10;/h3H,2,4-5H2,1H3,(H,9,10);1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Arecaidine hydrochloride

DescriptionArecaidine hydrochloride may have carcinogenesis.
In vivo

The metabolic interconversion of arecoline and arecoline 1-oxide in the rat.[Pubmed: 5123883 ]

Biochem J. 1971 May;122(4):503-8.


METHODS AND RESULTS:
1. Tritiation of arecoline hydrochloride by catalytic exchange in aqueous media (done by The Radiochemical Centre) gave Arecaidine hydrochloride of high specific radioactivity; this on treatment with diazomethane gave [(3)H]arecoline, which was oxidized with peroxyacetic acid to [(3)H]arecoline 1-oxide. 2. Arecoline 1-oxide gave arecaidine 1-oxide on acid hydrolysis and 1,2-dihydro-1-methylnicotinic acid methyl ester on thermal decomposition. 3. [(3)H]Arecoline hydrochloride was metabolized in the rat into the (3)H-labelled derivatives of arecoline 1-oxide, arecaidine 1-oxide, arecaidine, N-acetyl-S-(3-carboxy-1-methylpiperid-4-yl)-l-cysteine and an unidentified metabolite; some unchanged arecoline was also excreted.
CONCLUSIONS:
[(3)H]Arecoline 1-oxide gave the same metabolities, but in different amounts. 4. The possible relevance of these findings to betel-nut carcinogenesis is discussed.

Arecaidine hydrochloride Dilution Calculator

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Arecaidine hydrochloride Molarity Calculator

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Preparing Stock Solutions of Arecaidine hydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.6297 mL 28.1484 mL 56.2968 mL 112.5936 mL 140.742 mL
5 mM 1.1259 mL 5.6297 mL 11.2594 mL 22.5187 mL 28.1484 mL
10 mM 0.563 mL 2.8148 mL 5.6297 mL 11.2594 mL 14.0742 mL
50 mM 0.1126 mL 0.563 mL 1.1259 mL 2.2519 mL 2.8148 mL
100 mM 0.0563 mL 0.2815 mL 0.563 mL 1.1259 mL 1.4074 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Arecaidine hydrochloride

The metabolic interconversion of arecoline and arecoline 1-oxide in the rat.[Pubmed:5123883]

Biochem J. 1971 May;122(4):503-8.

1. Tritiation of arecoline hydrochloride by catalytic exchange in aqueous media (done by The Radiochemical Centre) gave Arecaidine hydrochloride of high specific radioactivity; this on treatment with diazomethane gave [(3)H]arecoline, which was oxidized with peroxyacetic acid to [(3)H]arecoline 1-oxide. 2. Arecoline 1-oxide gave arecaidine 1-oxide on acid hydrolysis and 1,2-dihydro-1-methylnicotinic acid methyl ester on thermal decomposition. 3. [(3)H]Arecoline hydrochloride was metabolized in the rat into the (3)H-labelled derivatives of arecoline 1-oxide, arecaidine 1-oxide, arecaidine, N-acetyl-S-(3-carboxy-1-methylpiperid-4-yl)-l-cysteine and an unidentified metabolite; some unchanged arecoline was also excreted. [(3)H]Arecoline 1-oxide gave the same metabolities, but in different amounts. 4. The possible relevance of these findings to betel-nut carcinogenesis is discussed.

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