Corypalmine

CAS# 6018-40-2

Corypalmine

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Chemical structure

Corypalmine

3D structure

Chemical Properties of Corypalmine

Cas No. 6018-40-2 SDF Download SDF
PubChem ID 11186895 Appearance Yellow powder
Formula C20H23NO4 M.Wt 341.4
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (13aS)-2,9,10-trimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-3-ol
SMILES COC1=C(C2=C(CC3C4=CC(=C(C=C4CCN3C2)O)OC)C=C1)OC
Standard InChIKey BMCZTYDZHNTKPR-INIZCTEOSA-N
Standard InChI InChI=1S/C20H23NO4/c1-23-18-5-4-12-8-16-14-10-19(24-2)17(22)9-13(14)6-7-21(16)11-15(12)20(18)25-3/h4-5,9-10,16,22H,6-8,11H2,1-3H3/t16-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Corypalmine

The bulbs of Corydalis yanhusuo

Biological Activity of Corypalmine

Description1. Corypalmine (IC50=128.0±10.5 uM) can inhibit prolyl oligopeptidase. 2. (-)-Corypalmine shows inhibition activity against spore germination of some fungi.
TargetsAntifection

Corypalmine Dilution Calculator

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Corypalmine Molarity Calculator

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Preparing Stock Solutions of Corypalmine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9291 mL 14.6456 mL 29.2912 mL 58.5823 mL 73.2279 mL
5 mM 0.5858 mL 2.9291 mL 5.8582 mL 11.7165 mL 14.6456 mL
10 mM 0.2929 mL 1.4646 mL 2.9291 mL 5.8582 mL 7.3228 mL
50 mM 0.0586 mL 0.2929 mL 0.5858 mL 1.1716 mL 1.4646 mL
100 mM 0.0293 mL 0.1465 mL 0.2929 mL 0.5858 mL 0.7323 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Corypalmine

New alkaloids from Corydalis species.[Pubmed:19235025]

Nat Prod Res. 2009;23(3):250-5.

A new alkaloid, chaerophylline (1), together with known alkaloids (-)-Corypalmine, berberine chloride, (-)-isoCorypalmine, (-)-corydalmine and (+)-bicuculline have been isolated from the crude base fraction of Corydalis chaerophylla. The crude base fractions of Corydalis longipes gave a new alkaloid, longicine (4), together with known alkaloids (+/-)-alpha-hydrastine, (+/-)-beta-hydrastine, N-methylhydrasteine hydroxylactam, 1-methoxyberberine chloride and berberinium hydroxide. These alkaloids are reported for the first time from the above species and their structures were established by chemical and spectroscopic evidence.

Isoquinoline alkaloids as prolyl oligopeptidase inhibitors.[Pubmed:25863351]

Fitoterapia. 2015 Jun;103:192-6.

Prolyl oligopeptidase is a cytosolic serine peptidase that hydrolyses proline-containing peptides at the carboxy terminus of proline residues. It has been associated with schizophrenia, bipolar affective disorder, and related neuropsychiatric disorders and therefore may have important clinical implications. Thirty-one isoquinoline alkaloids of various structural types, previously isolated in our laboratory, were screened for their ability to inhibit prolyl oligopeptidase. Promising results have been showed by alkaloids californidine (IC50=55.6+/-3.5 muM), dihydrosanquinarine (IC50=99.1+/-7.6 muM), Corypalmine (IC50=128.0+/-10.5 muM) and N-methyllaurotetanine (IC50=135.0+/-11.7 muM).

Efficacy of alkaloid (-)-corypalmine against spore germination of some fungi.[Pubmed:12094740]

Folia Microbiol (Praha). 2002;47(3):287-90.

Inhibition activity of the alkaloid (-)-Corypalmine on spore germination of plant pathogenic and saprophytic fungi (Alternaria solani, A brassicicola, A. brassicae, A. melongenae, Curvularia pallescens, C. lunata, C. maculans, Curvularisa sp., Colletotrichum sp., Helminthosporium speciferum, H. frumentacei, H. pennisetti, Heterosporium sp., Penicillum sp., Ustilago cynodontis) was determined. Spore germination of all the tested fungi was inhibited, Heterosporium sp. and Ustilago cynodontis being the most sensitive (complete inhibition of spore germination was observed at the very low concentration of 200 ppm). Curvularia palliscens, C. maculans and Curvularia sp. were less sensitive; complete inhibition of spore germination occurred at 400 ppm.

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