ScoulerineCAS# 6451-73-6 |
Quality Control & MSDS
3D structure
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Number of papers citing our products
| Cas No. | 6451-73-6 | SDF | Download SDF |
| PubChem ID | 22955 | Appearance | Powder |
| Formula | C19H21NO4 | M.Wt | 327.4 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 3,10-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,9-diol | ||
| SMILES | COC1=C(C2=C(CC3C4=CC(=C(C=C4CCN3C2)OC)O)C=C1)O | ||
| Standard InChIKey | KNWVMRVOBAFFMH-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C19H21NO4/c1-23-17-4-3-11-7-15-13-9-16(21)18(24-2)8-12(13)5-6-20(15)10-14(11)19(17)22/h3-4,8-9,15,21-22H,5-7,10H2,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Scoulerine shows significant cytotoxic effects against both two cancer cell lines (Caco-2 and Hep-G2 cancer cells), with IC50 values 6.44 ± 0.87 and 4.57 ± 0.42, respectively. 2. Scoulerine shows antiplasmodial activity with IC(50) values of 5.4uM and 3.1uM against the antifolate sensitive and the multidrug resistant P. falciparum strains: TM4/8.2 and K1CB1, respectively. |
| Targets | Antifection |
Scoulerine Dilution Calculator
Scoulerine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.0544 mL | 15.2718 mL | 30.5437 mL | 61.0874 mL | 76.3592 mL |
| 5 mM | 0.6109 mL | 3.0544 mL | 6.1087 mL | 12.2175 mL | 15.2718 mL |
| 10 mM | 0.3054 mL | 1.5272 mL | 3.0544 mL | 6.1087 mL | 7.6359 mL |
| 50 mM | 0.0611 mL | 0.3054 mL | 0.6109 mL | 1.2217 mL | 1.5272 mL |
| 100 mM | 0.0305 mL | 0.1527 mL | 0.3054 mL | 0.6109 mL | 0.7636 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Cytotoxicity of Naturally Occurring Isoquinoline Alkaloids of Different Structural Types.[Pubmed:27534109]
Nat Prod Commun. 2016 Jun;11(6):753-6.
Forty-six isoquinoline alkaloids, of eleven structural types isolated in our laboratory, have been evaluated for their cytotoxicity against two cancer cell lines (Caco-2 and Hep-G2 cancer cells), as well as against normal human lung fibroblast cells. Only Scoulerine, aromoline, berbamine and parfumidine showed significant cytotoxic effects, but only Scoulerine was active against both Caco-2 and Hep-G2 cells (IC50 values 6.44 +/- 0.87 and 4.57 +/- 0.42, respectively). Unfortunately, except for parfumidine, the other active alkaloids were also cytotoxic to the normal human lung fibroblast cells.
Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia.[Pubmed:22796506]
J Ethnopharmacol. 2012 Aug 30;143(1):310-3.
ETHNOPHARMACOLOGICAL RELEVANCE: Corydalis dubia is used in Bhutanese traditional medicine as a febrifuge and for treating infections in the blood, liver and bile which correlate to the signs and symptoms of malarial and microbial infections. AIM OF THE STUDY: To validate the ethnopharmacological uses of the plant and to discover potential new therapeutic drug leads. MATERIALS AND METHODS: C. dubia was collected from Bhutan and the alkaloids were obtained using acid-base fractionation and separation by repeated column and preparative plate chromatography. The alkaloids were identified from analysis of their physiochemical and spectroscopic data and were tested for antiplasmodial, antimicrobial and cytotoxicity activities. RESULTS: A systematic extraction and isolation protocol yielded one new natural product, dubiamine, and seven known isoquinoline alkaloids, Scoulerine, cheilanthifoline, protopine, capnoidine, bicuculline, corydecumbine and hydrastine. Among the four alkaloids tested, Scoulerine showed the best antiplasmodial activity with IC(50) values of 5.4muM and 3.1muM against the antifolate sensitive and the multidrug resistant P. falciparum strains: TM4/8.2 and K1CB1, respectively. None of the alkaloids tested showed significant antimicrobial or cytotoxicity activities. CONCLUSIONS: The antiplasmodial test results, of the isolated alkaloid components, are commensurated with the ethnopharmacological uses of this plant.
