DemethylwedelolactoneCAS# 6468-55-9 |
Quality Control & MSDS
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| Cas No. | 6468-55-9 | SDF | Download SDF |
| PubChem ID | 5489605 | Appearance | Yellow powder |
| Formula | C15H8O7 | M.Wt | 300.21 |
| Type of Compound | Coumarins | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 1,3,8,9-tetrahydroxy-[1]benzofuro[3,2-c]chromen-6-one | ||
| SMILES | C1=C(C=C2C(=C1O)C3=C(C4=CC(=C(C=C4O3)O)O)C(=O)O2)O | ||
| Standard InChIKey | LUTYTNLPIUCKBJ-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C15H8O7/c16-5-1-9(19)13-11(2-5)22-15(20)12-6-3-7(17)8(18)4-10(6)21-14(12)13/h1-4,16-19H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Demethylwedelolactone has trypsin inhibitory effect, it exerts anti-invasive growth effect on breast cancer cells. |
| Targets | NF-kB | IkB | MEK | ERK | MMP(e.g.TIMP) | IKK |
| In vitro | Trypsin inhibitory effect of wedelolactone and demethylwedelolactone.[Pubmed: 12722155]Phytother Res. 2003 Apr;17(4):420-1. Wedelolactone (WL) and Demethylwedelolactone (DWL) isolated from Eclipta alba were tested in the trypsin inhibition bioassay (in vitro). Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice.[Pubmed: 22926226]Eur J Med Chem. 2012 Oct;56:361-7.The anticancer properties of Demethylwedelolactone (DWEL) and wedelolactone (WEL), which are naturally occurring coumestans, have not been well characterized. In this study, we investigated the anti-invasive effects of synthetic WEL and Demethylwedelolactone on human MDA-MB-231 breast cancer cells. |
Demethylwedelolactone Dilution Calculator
Demethylwedelolactone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.331 mL | 16.655 mL | 33.31 mL | 66.62 mL | 83.275 mL |
| 5 mM | 0.6662 mL | 3.331 mL | 6.662 mL | 13.324 mL | 16.655 mL |
| 10 mM | 0.3331 mL | 1.6655 mL | 3.331 mL | 6.662 mL | 8.3275 mL |
| 50 mM | 0.0666 mL | 0.3331 mL | 0.6662 mL | 1.3324 mL | 1.6655 mL |
| 100 mM | 0.0333 mL | 0.1666 mL | 0.3331 mL | 0.6662 mL | 0.8328 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Trypsin inhibitory effect of wedelolactone and demethylwedelolactone.[Pubmed:12722155]
Phytother Res. 2003 Apr;17(4):420-1.
Wedelolactone (WL) and Demethylwedelolactone (DWL) isolated from Eclipta alba were tested in the trypsin inhibition bioassay (in vitro). Both compounds showed potent activity. IC(50) values of WL and DWL were found to be 2.9 and 3.0 microg/mL respectively.
Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice.[Pubmed:22926226]
Eur J Med Chem. 2012 Oct;56:361-7.
The anticancer properties of Demethylwedelolactone (DWEL) and wedelolactone (WEL), which are naturally occurring coumestans, have not been well characterized. In this study, we investigated the anti-invasive effects of synthetic WEL and DWEL on human MDA-MB-231 breast cancer cells. We found that WEL and DWEL inhibited the anchorage-independent growth and also suppressed cell motility and cell invasion of MDA-MB-231 cells. In addition, WEL and DWEL reduced the activity and expression of matrix metalloproteinases (MMPs) involved in blocking the IkappaB-alpha/NFkappaB and MEK/ERK signaling pathways in MDA-MB-231 cells. Furthermore, DWEL suppressed the metastasis and lung colonization of the tumor cells in the nude mice. Altogether, these data suggest that DWEL derivatives exert anti-invasive growth effect on breast cancer cells.
