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Isodemethylwedelolacton

CAS# 350681-33-3

Isodemethylwedelolacton

Catalog No. BCN2766----Order now to get a substantial discount!

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Isodemethylwedelolacton: 5mg $40 In Stock
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Quality Control of Isodemethylwedelolacton

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Chemical structure

Isodemethylwedelolacton

3D structure

Chemical Properties of Isodemethylwedelolacton

Cas No. 350681-33-3 SDF Download SDF
PubChem ID 5318547 Appearance Yellow powder
Formula C15H8O7 M.Wt 300.22
Type of Compound Coumarins Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2,4,8,9-tetrahydroxy-[1]benzofuro[3,2-c]chromen-6-one
SMILES C1=C(C=C2C(=C1O)OC(=O)C3=C2OC4=CC(=C(C=C43)O)O)O
Standard InChIKey OBEHELRBTWMPHI-UHFFFAOYSA-N
Standard InChI InChI=1S/C15H8O7/c16-5-1-7-13(10(19)2-5)22-15(20)12-6-3-8(17)9(18)4-11(6)21-14(7)12/h1-4,16-19H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Isodemethylwedelolacton

The herbs of Eclipta prostrata

Biological Activity of Isodemethylwedelolacton

DescriptionIsodemethylwedelolactone is a natural product from the Eclipta prostrata.

Protocol of Isodemethylwedelolacton

Structure Identification
Yao Xue Xue Bao. 2001 Jan;36(1):34-7.

Studies on the chemical constituents of Eclipta prostrata (L).[Pubmed: 12579857]

To study the chemical constituents of Eclipta prostrata (L).
METHODS AND RESULTS:
The constituents of E. prostrata were systematically separated with the Bohlmann method and percolation and hot extraction methods, and various chromatographies. The structures were elucidated by chemical and spectroscopic means. RESULTS: Ten compounds were isolated from the Eclipta prostrata. Their structures were determined as wedelolactone (1), demethylwedelolactone (2), Isodemethylwedelolactone (3), alpha-formylterthienyl (4), strychnolactone (5), beta-sitosterol (6), nonacosanol (7), stearic acid (8), lacceroic acid (9), 3,4-dihydoxy benzoic acid (10). Fourteen ocmpounds, including hydrocarbons and its esters were identified by GC-MS from the least polar fractions.
CONCLUSIONS:
Compound 3 is a new coumestan named Isodemethylwedelolactone. Compounds 2-10 and compounds characterized by GC-MS analysis were obtained for the first time from Eclipta prostrata.

Isodemethylwedelolacton Dilution Calculator

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Isodemethylwedelolacton Molarity Calculator

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Preparing Stock Solutions of Isodemethylwedelolacton

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.3309 mL 16.6545 mL 33.3089 mL 66.6178 mL 83.2723 mL
5 mM 0.6662 mL 3.3309 mL 6.6618 mL 13.3236 mL 16.6545 mL
10 mM 0.3331 mL 1.6654 mL 3.3309 mL 6.6618 mL 8.3272 mL
50 mM 0.0666 mL 0.3331 mL 0.6662 mL 1.3324 mL 1.6654 mL
100 mM 0.0333 mL 0.1665 mL 0.3331 mL 0.6662 mL 0.8327 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Isodemethylwedelolacton

[Studies on the chemical constituents of Eclipta prostrata (L)].[Pubmed:12579857]

Yao Xue Xue Bao. 2001 Jan;36(1):34-7.

AIM: To study the chemical constituents of Eclipta prostrata (L). METHODS: The constituents of E. prostrata were systematically separated with the Bohlmann method and percolation and hot extraction methods, and various chromatographies. The structures were elucidated by chemical and spectroscopic means. RESULTS: Ten compounds were isolated from the Eclipta prostrata. Their structures were determined as wedelolactone (1), demethylwedelolactone (2), Isodemethylwedelolactone (3), alpha-formylterthienyl (4), strychnolactone (5), beta-sitosterol (6), nonacosanol (7), stearic acid (8), lacceroic acid (9), 3,4-dihydoxy benzoic acid (10). Fourteen ocmpounds, including hydrocarbons and its esters were identified by GC-MS from the least polar fractions. CONCLUSION: Compound 3 is a new coumestan named Isodemethylwedelolactone. Compounds 2-10 and compounds characterized by GC-MS analysis were obtained for the first time from Eclipta prostrata.

[Simultaneous determination of wedelolactone and isodemethylwedelolactone in Herba ecliptae by reversed-phase high performance liquid chromatography].[Pubmed:17679432]

Se Pu. 2007 May;25(3):371-3.

A reversed-phase high performance liquid chromatographic method (RP-HPLC) was developed for the simultaneous determination of wedelolactone and Isodemethylwedelolactone in Herba Ecliptae from different sources. The separation was performed on a Kromasil C18 column (250 mm x 4.6 mm, 5 microm), with methanol-0.5% acetic acid (55 45, v/v) as mobile phase at a flow rate of 1.0 mL/min. The detection wavelength was set at 351 nm and the volume of injection was 20 microL. There were good linear relationships between the mass concentrations and the peak areas of Isodemethylwedelolactone and wedelolactone in the ranges of 1.6 - 32.0 mg/L (r = 0.999 5) and 5.6 - 112.0 mg/L (r = 0.999 8), respectively. The recoveries were found to be in the range of 97.5% - 98.2% and 99.0% - 100.2%, respectively. The results of the experiments have demonstrated that the established method is rapid and simple with good accuracy and reproducibility for the simultaneous determination of wedelolactone and Isodemethylwedelolactone. The method is suitable for the quality control of Herba Ecliptae from different sources.

Description

Isodemethylwedelolactone is a kind of procoagulant and haemolytic constituent isolated from Eclipta alba.

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