Coleonol B

CAS# 64657-21-2

Coleonol B

Catalog No. BCN4188----Order now to get a substantial discount!

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Quality Control of Coleonol B

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Chemical structure

Coleonol B

3D structure

Chemical Properties of Coleonol B

Cas No. 64657-21-2 SDF Download SDF
PubChem ID 10001602 Appearance White powder
Formula C22H34O7 M.Wt 410.5
Type of Compound Diterpenoids Storage Desiccate at -20°C
Synonyms Coleonol B; Excolabdone C
Solubility Soluble in ethanol and methanol; insoluble in water
Chemical Name [(3R,4aR,5S,6S,10S,10aR,10bS)-3-ethenyl-5,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-6-yl] acetate
SMILES CC(=O)OC1C2C(CCC(C2(C3(C(=O)CC(OC3(C1O)C)(C)C=C)O)C)O)(C)C
Standard InChIKey CLOQVZCSBYBUPB-VDCUXWMXSA-N
Standard InChI InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(28-12(2)23)17(26)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16?,17-,19-,20-,21+,22-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Coleonol B

The herbs of Coleus forskohlii

Biological Activity of Coleonol B

DescriptionColeonol B a natural product from Coleus forskohlii.

Protocol of Coleonol B

Structure Identification
Zeitschrift für Kristallographie - Crystalline Materials, 1991, 194(1-4):229-234.

Molecular and crystal structure of Coleonol-B, C22H34O7*[Reference: WebLink]

Coleonol B a diterpenoid isolated from the roots of the Indian plant Coleus forskohlii crystallizes in the orthorhombic system, space group P2(1)2(1)2(1) with a = 29.085(5), b = 11.603(2), c = 6.341(1) angstrom and four molecules in the unit cell. As in Coleonol, the substituents at the 6- and 7-positions are in the beta-configuration. 2133 reflections were used, 398 parameters were refined. Final R-values were R(w) = 0.057 and R = 0.045.

Coleonol B Dilution Calculator

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Coleonol B Molarity Calculator

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Preparing Stock Solutions of Coleonol B

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4361 mL 12.1803 mL 24.3605 mL 48.7211 mL 60.9013 mL
5 mM 0.4872 mL 2.4361 mL 4.8721 mL 9.7442 mL 12.1803 mL
10 mM 0.2436 mL 1.218 mL 2.4361 mL 4.8721 mL 6.0901 mL
50 mM 0.0487 mL 0.2436 mL 0.4872 mL 0.9744 mL 1.218 mL
100 mM 0.0244 mL 0.1218 mL 0.2436 mL 0.4872 mL 0.609 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Coleonol B

Comparative evaluation of cytotoxic, antimicrobial and antioxidant activities of the crude extracts of three Plectranthus species grown in Saudi Arabia.[Pubmed:30766425]

Saudi Pharm J. 2019 Feb;27(2):162-170.

Natural products from medicinal plants represent major resource of novel therapeutic substances for combating serious diseases including cancers and microbial infections. The genus Plectranthus (Family: Labiatae) represents a large and widespread group of species with a diversity of traditional uses in treatment of various ailments. Therefore, this research study aimed to evaluate the cytotoxic, antimicrobial and antioxidant activities of three Plectranthus species growing in Saudi Arabia namely P. cylindraceus Hocst. ex Benth., P. asirensis JRI Wood and P. barbatus Andrews. Moreover, this work focused on the isolation of the active constituents responsible for the activities from the most active Plectranthus species. The extracts were tested for their cytotoxic activity against three cancer cell lines (Hela, HepG2 and HT-29), using MTT-test, antimicrobial activity against Gram positive, Gram negative bacterial and fungal strains using broth micro-dilution assay for minimum inhibitory and bactericidal concentrations (MIC and MBC) and antioxidant activity using scavenging activity of DPPH radical and beta-carotene-linoleic acid methods. The ethanolic extracts of the Plectranthus species showed remarkable cytotoxic activity against all cancer cell lines with IC50 values ranging between 10.1+/-0.33 to 102.6+/-8.66mug/mL and a great and antimicrobial activity with MIC values between 62.5 and 250microg/mL. In addition, the three Plectranthus species showed almost moderate antioxidant activity. The most interesting cytotoxic and antimicrobial results were observed with the extract of P. barbatus. Consequently, this extract was partitioned between water and n-hexane, chloroform and n-butanol and tested. The cytotoxic activity resided predominantly in the n-hexane and chloroform fractions. The analysis of the chloroform fraction led to the isolation of four diterpenoid compounds, two of labdane- and two of abietane-type, which were identified as Coleonol B, forskolin, sugiol and 5,6-dehydrosugiol. Purification of the n-hexane fraction led to isolation of a major abietane-type diterpene, which was identified as ferruginol. Sugiol, 5,6-dehydrosugiol and ferruginol were isolated for the first time from P. barbatus in this study. The isolated diterpenoids showed variable cytotoxic effects with IC50 values between 15.1+/-2.03 and 242+/-13.3microg/mL, a great antimicrobial activity with MIC values between 15.6 and 129microg/mL and a total antioxidant activity ranging from 23.1+/-2.9 to 69.2+/-3.8%.

Description

Isoforskolin is the principle active component of C. forskohlii native to China. Isoforskolin reduces the secretion of lipopolysaccharide (LPS)-induced cytokines, namely TNF-α, IL-1β, IL-6 and IL-8, in human mononuclear leukocytes. Isoforskolin acts as an anti-inflammatory agent for the treatment of Lyme arthritis.

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