AzaphenPotent ST inhibitor,antidepressant CAS# 24853-80-3 |
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Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 24853-80-3 | SDF | Download SDF |
| PubChem ID | 159976 | Appearance | Powder |
| Formula | C16H21Cl2N5O | M.Wt | 370.28 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 5-methyl-3-(4-methylpiperazin-1-yl)pyridazino[3,4-b][1,4]benzoxazine;dihydrochloride | ||
| SMILES | CN1CCN(CC1)C2=NN=C3C(=C2)N(C4=CC=CC=C4O3)C.Cl.Cl | ||
| Standard InChIKey | ZZVWCKAYZSAUKR-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C16H19N5O.2ClH/c1-19-7-9-21(10-8-19)15-11-13-16(18-17-15)22-14-6-4-3-5-12(14)20(13)2;;/h3-6,11H,7-10H2,1-2H3;2*1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Azaphen Dilution Calculator
Azaphen Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.7007 mL | 13.5033 mL | 27.0066 mL | 54.0132 mL | 67.5165 mL |
| 5 mM | 0.5401 mL | 2.7007 mL | 5.4013 mL | 10.8026 mL | 13.5033 mL |
| 10 mM | 0.2701 mL | 1.3503 mL | 2.7007 mL | 5.4013 mL | 6.7516 mL |
| 50 mM | 0.054 mL | 0.2701 mL | 0.5401 mL | 1.0803 mL | 1.3503 mL |
| 100 mM | 0.027 mL | 0.135 mL | 0.2701 mL | 0.5401 mL | 0.6752 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Azaphen is an antidepressant having effects on the autonomic nervous system; the drug is especially effective for mild and moderate depressions and a combination of Azaphen and Thymol is applicable for severa depressions. Azaphen improves sleep too.
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[Preclinical investigation of pharmaceuticals impact against cytochrome P450 activity and prognosis of substrate affinity as means for providing substrate therapy safety].[Pubmed:24757832]
Antibiot Khimioter. 2013;58(7-8):34-9.
Tricyclic antidepressants, not influencing the P450 3A4 activity, are safe in combination with drugs of other groups used in the treatment of comorbid patients. Azaphen is is one of the agents most widely used in the clinical practice. The in vitro electrochemical analysis showed that pipofezin (Azaphen) was not a substrate, inductor, and/or inhibitor of cytochrome P450 CYP3A4 isoenzymes. The Guzar programme computer modelling and the literature data demonstrated the substrate affinity of pipifezin to CYP1A2.
[Atypical antidepressants: effect on synaptosomal uptake of serotonin and GABA].[Pubmed:7198493]
Biull Eksp Biol Med. 1981 Nov;92(11):564-6.
Effect of the antidepressants of different chemical groups--imipramine, desmethylimipramine, chlorimipramine, befuralin, trazodon, pyrazidol, inkasan and Azaphen--on the uptake of 3H-serotonin and 3H-GABA by the crude synaptosomal fraction of the rat brain was studied. The Cm values for the uptake of serotonin and GABA were 0.195 and 30 micro M, respectively. Inkasan and Azaphen were the most potent inhibitors of the 3H-serotonin uptake (65-70% inhibition at a concentration of 50 micro M. Azaphen and chlorimipramine were the only ones to inhibit the uptake of 3H-GABA at a concentration of 50 micro M. The majority of the antidepressants studied inhibited the GABA uptake only at high concentrations.
