AzathramycinMacrolide antibiotic CAS# 76801-85-9 |
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Quality Control & MSDS
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| Cas No. | 76801-85-9 | SDF | Download SDF |
| PubChem ID | 9810601 | Appearance | Powder |
| Formula | C37H70N2O12 | M.Wt | 734.96 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | Azaerythromycin A; 9-Deoxo-9a-aza-9a-homoerythromycin A; Desmethyl Azithromycin | ||
| Solubility | DMSO : 33.33 mg/mL (45.35 mM; Need ultrasonic) | ||
| Chemical Name | (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one | ||
| SMILES | CCC1C(C(C(NCC(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)O)(C)O | ||
| Standard InChIKey | HRKNNHYKWGYTEN-HOQMJRDDSA-N | ||
| Standard InChI | InChI=1S/C37H70N2O12/c1-14-26-37(10,45)30(41)23(6)38-18-19(2)16-35(8,44)32(51-34-28(40)25(39(11)12)15-20(3)47-34)21(4)29(22(5)33(43)49-26)50-27-17-36(9,46-13)31(42)24(7)48-27/h19-32,34,38,40-42,44-45H,14-18H2,1-13H3/t19-,20-,21+,22-,23-,24+,25+,26-,27+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Azithromycin, derived from erythromycin, is a antibiotic. Azithromycin binds to the 50S subunit of the bacterial ribosome, and thus inhibits translation of mRNA.
IC50 Value:
Target: Antibacterial
Azithromycin is an azalide, a subclass of macrolide antibiotics. Azithromycin is one of the world's best-selling antibiotics.
in vitro: The geometric mean 50% inhibitory concentration (IC50) of azithromycin was 2,570.3 (95% CI=2,175.58 to 3,036.58) ng/ml [1]. Azithromycin, clarithromycin and roxithromycin inhibited the proliferation of both the concanavalin A- and superantigen-stimulated PBMCs dose-dependently. The effect of azithromycin was the strongest, with IC50 values of less than 5 ?g/ml [2].
in vivo: Azithromycin produced a slightly higher percentage of patients with a greater than 80% reduction in their inflammatory acne lesions (85.7%) vs. an average of 77.1% for all other agents [3].
Clinical trial: References: | |||||
Azathramycin Dilution Calculator
Azathramycin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.3606 mL | 6.8031 mL | 13.6062 mL | 27.2124 mL | 34.0155 mL |
| 5 mM | 0.2721 mL | 1.3606 mL | 2.7212 mL | 5.4425 mL | 6.8031 mL |
| 10 mM | 0.1361 mL | 0.6803 mL | 1.3606 mL | 2.7212 mL | 3.4015 mL |
| 50 mM | 0.0272 mL | 0.1361 mL | 0.2721 mL | 0.5442 mL | 0.6803 mL |
| 100 mM | 0.0136 mL | 0.068 mL | 0.1361 mL | 0.2721 mL | 0.3402 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Description: IC50 Value: N/A Azithromycin (Zithromax, Azithrocin, Zmax, Azin, Zedd) is an azalide, a subclass of macrolide antibiotics. Azithromycin is one of the world's best-selling antibiotics. in vitro: The geometric mean 50% inhibitory concentration (IC50) of azithromycin was 2,570.3 (95% CI=2,175.58 to 3,036.58) ng/ml [1]. Azithromycin, clarithromycin and roxithromycin inhibited the proliferation of both the concanavalin A- and superantigen-stimulated PBMCs dose-dependently. The effect of azithromycin was the strongest, with IC50 values of less than 5 ?g/ml [2]. in vivo: Azithromycin produced a slightly higher percentage of patients with a greater than 80% reduction in their inflammatory acne lesions (85.7%) vs. an average of 77.1% for all other agents [3]. Clinical trial: N/A
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Azathramycin (Azaerythromycin A) is an antibiotic.
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