Benzo[b]thiophene-2-carboxylic acidCAS# 6314-28-9 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 6314-28-9 | SDF | Download SDF |
PubChem ID | 95864 | Appearance | Powder |
Formula | C9H6O2S | M.Wt | 178 |
Type of Compound | N/A | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | 1-benzothiophene-2-carboxylic acid | ||
SMILES | C1=CC=C2C(=C1)C=C(S2)C(=O)O | ||
Standard InChIKey | DYSJMQABFPKAQM-UHFFFAOYSA-N | ||
Standard InChI | InChI=1S/C9H6O2S/c10-9(11)8-5-6-3-1-2-4-7(6)12-8/h1-5H,(H,10,11) | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Benzo[b]thiophene-2-carboxylic acid Dilution Calculator
Benzo[b]thiophene-2-carboxylic acid Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 5.618 mL | 28.0899 mL | 56.1798 mL | 112.3596 mL | 140.4494 mL |
5 mM | 1.1236 mL | 5.618 mL | 11.236 mL | 22.4719 mL | 28.0899 mL |
10 mM | 0.5618 mL | 2.809 mL | 5.618 mL | 11.236 mL | 14.0449 mL |
50 mM | 0.1124 mL | 0.5618 mL | 1.1236 mL | 2.2472 mL | 2.809 mL |
100 mM | 0.0562 mL | 0.2809 mL | 0.5618 mL | 1.1236 mL | 1.4045 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Withanolide S
Catalog No.:BCN6728
CAS No.:63139-16-2
- NSC-41589
Catalog No.:BCC5477
CAS No.:6310-41-4
- Beta-boswellic acid
Catalog No.:BCN2367
CAS No.:631-69-6
- Quillaic acid
Catalog No.:BCC5310
CAS No.:631-01-6
- (±)-threo-3-Methylglutamic acid
Catalog No.:BCC6804
CAS No.:63088-04-0
- Boc-Thr-OSu
Catalog No.:BCC3450
CAS No.:63076-44-8
- H-Val-OMe.HCl
Catalog No.:BCC3142
CAS No.:6306-52-1
- Asunaprevir (BMS-650032)
Catalog No.:BCC1374
CAS No.:630420-16-5
- Estradiol-3-benzoate-17-butyrate
Catalog No.:BCC8963
CAS No.:63042-18-2
- H-Tle-OMe.HCl
Catalog No.:BCC2658
CAS No.:63038-27-7
- Senkyunolide
Catalog No.:BCN8154
CAS No.:63038-10-8
- Hexacosyl (E)-ferulate
Catalog No.:BCN4170
CAS No.:63034-29-7
- 4-(Phenylthio)benzyl alcohol
Catalog No.:BCC8653
CAS No.:6317-56-2
- Methyl 2,5-dihydroxycinnamate
Catalog No.:BCC6702
CAS No.:63177-57-1
- 4-Acetoxy-3,5-dimethoxybenzoic acid
Catalog No.:BCN5364
CAS No.:6318-20-3
- H-D-Thr-OH
Catalog No.:BCC3108
CAS No.:632-20-2
- Rose Bengal
Catalog No.:BCC8024
CAS No.:632-69-9
- Wogonin
Catalog No.:BCN4171
CAS No.:632-85-9
- Pifithrin-α (PFTα)
Catalog No.:BCC2241
CAS No.:63208-82-2
- Cannabispirenone A
Catalog No.:BCN7603
CAS No.:63213-00-3
- Ginsenoside Rh1
Catalog No.:BCN1069
CAS No.:63223-86-9
- Benzoylhypacoitine
Catalog No.:BCN2821
CAS No.:63238-66-4
- Benzoylmesaconine
Catalog No.:BCN5398
CAS No.:63238-67-5
- AH 7614
Catalog No.:BCC8044
CAS No.:6326-06-3
Synthesis and Antitubercular Activity of New Benzo[b]thiophenes.[Pubmed:27563398]
ACS Med Chem Lett. 2016 Jun 28;7(8):751-6.
In vitro and ex vivo efficacies of four series of Benzo[b]thiophene-2-carboxylic acid derivatives were studied against Mycobacterium tuberculosis H37Ra (MTB). Benzo[b]thiophenes were also tested in vitro against multidrug resistant Mycobacterium tuberculosis H37Ra (MDR-MTB), and 7b was found to be highly active against A- and D-MDR-MTB/MTB (MIC ranges 2.73-22.86 mug/mL). The activity of all benzo[b]thiophenes against M. bovis BCG (BCG) was also assessed grown under aerobic and under conditions of oxygen depletion. Compounds 8c and 8g showed significant activity with MICs of 0.60 and 0.61 mug/mL against dormant BCG. The low cytotoxicity and high selectivity index data against human cancer cell lines, HeLa, Panc-1, and THP-1 indicate the potential importance of the development of benzo[b]thiophene-based 1,3-diketones and flavones as lead candidates to treat mycobacterial infections. Molecular docking studies into the active site of DprE1 (Decaprenylphosphoryl-beta-d-ribose-2'-epimerase) enzyme revealed a similar binding mode to native ligand in the crystal structure thereby helping to understand the ligand-protein interactions and establish a structural basis for inhibition of MTB. In summary, its good activity in in vitro and ex vivo model, as well as its activity against multidrug-resistant M. tuberculosis H37Ra in a potentially latent state, makes 7b an attractive drug candidate for the therapy of tuberculosis.
Structure-activity relationships of 6-methyl-benzo[b]thiophene-2-carboxylic acid (1-[(S)-1-benzyl-4-[4-(tetrahydropyran-4-ylmethyl)piperazin-1-yl]butylcarbamoyl]c yclopentyl)amide, potent antagonist of the neurokinin-2 receptor.[Pubmed:20408549]
J Med Chem. 2010 May 27;53(10):4148-65.
As part of a project aimed at the identification of a series of small, orally available antagonists for the hNK(2) receptor, starting from one of our capped dipeptide libraries, we succeeded in the chemical optimization of the first identified leads, finally producing a class of molecules with significant activity in our animal model after iv administration. We herein report the results of further chemical modifications made to reduce the overall peptide character of this series and the consequent improvement of their in vivo antagonist activity. The present work identified 6-methylBenzo[b]thiophene-2-carboxylic acid (1-[(S)-1-benzyl-4-[4-(tetrahydropyran-4-ylmethyl)piperazin-1-yl]butylcarbamoyl]c yclopentyl)amide (10i), endowed with subnanomolar potency in all the in vitro tests and being highly potent and of long duration upon in vivo testing after both iv and id dosing.
Synthesis and pharmacological evaluation of 2-substituted benzo[b]thiophenes as anti-inflammatory and analgesic agents.[Pubmed:18433939]
Eur J Med Chem. 2009 Apr;44(4):1718-25.
An efficient method for trapping isocyanate 4, generated from the Curtius rearrangement, with ethyl alcohol to afford the carbamate 5 is reported. 5-NitroBenzo[b]thiophene-2-carboxylic acid 1 is converted to the corresponding hydrazide 2 by the reaction with hydrazine hydrate and then to the azide 3 with nitrous acid, followed by thermal rearrangement, cooling, and trapping in one pot reaction. The carbamate 5 is treated with hydrazine hydrate to afford the desired, Zileuton analogue, 4-(5-nitrobenzo[b]thiophene-2-yl)semicarbazide 6. Also the reactivity of hydrazide 2 towards some carboxyaldehydes and phenylisothiocyanate afforded the corresponding carbohydrazides 7, 8 and phenylthiosemicarbazide 9, respectively. Compounds 9, 2 and 6, respectively, were more potent as anti-inflammatory and anti-nociceptive agents.
MEN15596, a novel nonpeptide tachykinin NK2 receptor antagonist.[Pubmed:16979621]
Eur J Pharmacol. 2006 Nov 7;549(1-3):140-8.
The pharmacological profile of MEN15596 or (6-methyl-Benzo[b]thiophene-2-carboxylic acid [1-(2-phenyl-1R-{[1-(tetrahydropyran-4-ylmethyl)-piperidin-4-ylmethyl]-carbamoyl} -ethylcarbamoyl)-cyclopentyl]-amide), a novel potent and selective tachykinin NK2 receptor antagonist endowed with oral activity, is described. At the human recombinant tachykinin NK2 receptor, MEN15596 showed subnanomolar affinity (pKi 10.1) and potently antagonized (pKB 9.1) the neurokinin A-induced intracellular calcium release. MEN15596 selectivity for the tachykinin NK2 receptor was assessed by binding studies at the recombinant tachykinin NK1 (pKi 6.1) and NK3 (pKi 6.4) receptors, and at a number of 34 molecular targets including receptors, transporters and ion channels. In isolated smooth muscle preparations MEN15596 showed a marked species selectivity at the tachykinin NK2 receptor with the highest antagonist potency in guinea-pig colon, human and pig bladder (pKB 9.3, 9.2 and 8.8, respectively) whereas it was three orders of magnitude less potent in the rat and mouse urinary bladder (pKB 6.3 and 5.8, respectively). In agreement with binding experiments, MEN15596 showed low potency in blocking selective NK1 or NK3 receptor agonist-induced contractions of guinea-pig ileum preparations (pA2 The preparation of a series of 1H-imidazol-1-yl-substituted benzo[b]furan-, benzo[b]thiophene-, and indolecarboxylic acids is described. Most of the compounds were potent inhibitors of TxA2 synthetase in vitro, and the distance between the imidazole and carboxylic acid groups was found to be important for optimal potency. The most potent compound in vivo was 6-(1H-imidazol-1-ylmethyl)-3-methylBenzo[b]thiophene-2-carboxylic acid (71), which, in conscious dogs, showed a similar profile of activity to that of dazoxiben (1).Selective thromboxane synthetase inhibitors. 3. 1H-imidazol-1-yl-substituted benzo[b]furan-, benzo[b]thiophene-, and indole-2- and -3-carboxylic acids.[Pubmed:3746813]
J Med Chem. 1986 Sep;29(9):1637-43.