Bephenium HydroxynaphthoateAnthelmintic agent CAS# 3818-50-6 |
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Quality Control & MSDS
3D structure
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| Cas No. | 3818-50-6 | SDF | Download SDF |
| PubChem ID | 54678490 | Appearance | Powder |
| Formula | C28H29NO4 | M.Wt | 443.53 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : ≥ 44 mg/mL (99.20 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | benzyl-dimethyl-(2-phenoxyethyl)azanium;3-carboxynaphthalen-2-olate | ||
| SMILES | C[N+](C)(CCOC1=CC=CC=C1)CC2=CC=CC=C2.C1=CC=C2C=C(C(=CC2=C1)C(=O)O)[O-] | ||
| Standard InChIKey | PMPQCPQAHTXCDK-UHFFFAOYSA-M | ||
| Standard InChI | InChI=1S/C17H22NO.C11H8O3/c1-18(2,15-16-9-5-3-6-10-16)13-14-19-17-11-7-4-8-12-17;12-10-6-8-4-2-1-3-7(8)5-9(10)11(13)14/h3-12H,13-15H2,1-2H3;1-6,12H,(H,13,14)/q+1;/p-1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Bephenium Hydroxynaphthoate Dilution Calculator
Bephenium Hydroxynaphthoate Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.2546 mL | 11.2732 mL | 22.5464 mL | 45.0928 mL | 56.366 mL |
| 5 mM | 0.4509 mL | 2.2546 mL | 4.5093 mL | 9.0186 mL | 11.2732 mL |
| 10 mM | 0.2255 mL | 1.1273 mL | 2.2546 mL | 4.5093 mL | 5.6366 mL |
| 50 mM | 0.0451 mL | 0.2255 mL | 0.4509 mL | 0.9019 mL | 1.1273 mL |
| 100 mM | 0.0225 mL | 0.1127 mL | 0.2255 mL | 0.4509 mL | 0.5637 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Bephenium hydroxynaphthoate (INN, trade names Alcopara, Alcopar, Befenium, Debefenium, Francin, Nemex) is an anthelmintic agent formerly used in the treatment of hookworm infections and ascariasis.
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Pyrantel Embonate And Bephenium Hydroxynaphthoate In The Treatment Of Hookworm Infection.[Pubmed:12913463]
Kisaengchunghak Chapchi. 1975 Jun;13(1):19-30.
A total of 100 hookworm infested patients were divided into two groups. One group of 49 received pyrantel embonate in a single oral dose of 10 mg as the base per kg body weight and the other group of 51 a single oral dose of 5.0 gm Bephenium Hydroxynaphthoate for a comparison of efficacy on hookworm infestation and other intestinal helminths. Forty-two(85.7%) cases of hookworm treated with pyrantel embonate were cured and there was a 99.9 per cent mean reduction in fecal egg count. Of the 51 patients who received Bephenium Hydroxynaphthoate complete cure occurred in 76.5 per cent and the mean reduction in fecal egg count was 91.8 per cent. These results plus the lower incidence of side effects recorded in the pyrnatel group suggest that pyrantel embonate is the more desirable trestment. Pyrantel embonate was highly effective against Ascaris lumbricoides, Trichostrongylus orientalis and both drugs were moderately effective against Trichuris trichiura. During the course of the study measurements of hematology, biochemistry and examinations of urine specimens were carried out. All values were normal throughout the study and no significant difference was observed between pyrantel embonate and Bephenium Hydroxynaphthoate treated subjects. Side effects were more common in the Bephenium Hydroxynaphthoate treated group.
A comparative study of the relative efficacy of pyrantel pamoate, bephenium hydroxynaphthoate and tetrachlorethylene in the treatment of Necator americanus infection in Ceylon.[Pubmed:1155990]
Ann Trop Med Parasitol. 1975 Jun;69(2):233-9.
The clearance of hookworm (Necator americanus) ova by a single dose of tetrachlorethylene (T.C.E.) was compared with that produced by single and multiple dose regimes of Bephenium Hydroxynaphthoate and pyrantel pamoate. Single doses of bephenium and pyrantel were inferior to T.C.E. Three daily doses of bephenium or pyrantel produced effects comparable with a single dose of T.C.E. Because of the low cost and lack of side effects, T.C.E. remains the drug of choice in the treatment of N. americanus in infections; the only disadvantage of T.C.E. is its unnoticed deterioration under tropical conditions.
Controlled comparative study of the efficacy of pyrantel pamoate and a combined regimen of piperazine citrate and bephenium hydroxynaphthoate in the treatment of intestinal nemathelminthiases.[Pubmed:6287829]
Afr J Med Med Sci. 1981 Mar-Jun;10(1-2):63-7.
Pyrantel pamoate at a dose of 10 mg/kg body weight daily for 2 or 3 days was found to be more effective against Ascaris than both a regimen of Bephenium Hydroxynaphthoate (2.5 g base) and piperazine citrate (2-3 g) given daily for 2 days and a placebo-treated control group. The cure rates for pyrantel were about 95% compared to 90 and 20% for the other two groups respectively. None of the drug schedules was effective against the Trichuris. The bephenium/piperazine regimen was superior to both the 2-day and 3-day courses of pyrantel pamoate against the hookworm with aggregate cure rates of 58-60% for pyrantel pamoate and 68-85% for bephenium/piperazine. The results were better than those reported earlier in the series when a single dose of pyrantel pamoate (10 mg/kg of body weight) was used. Pyrantel pamoate was well tolerated and the drug merits further studies at higher doses, particularly against the hookworm.
