Coumarin VI

CAS# 38215-36-0

Coumarin VI

Catalog No. BCN7833----Order now to get a substantial discount!

Product Name & Size Price Stock
Coumarin VI: 5mg $6 In Stock
Coumarin VI: 10mg Please Inquire In Stock
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Quality Control of Coumarin VI

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Chemical structure

Coumarin VI

3D structure

Chemical Properties of Coumarin VI

Cas No. 38215-36-0 SDF Download SDF
PubChem ID 100334 Appearance Powder
Formula C20H18N2O2S M.Wt 350.44
Type of Compound Coumarins Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 3-(1,3-benzothiazol-2-yl)-7-(diethylamino)chromen-2-one
SMILES CCN(CC)C1=CC2=C(C=C1)C=C(C(=O)O2)C3=NC4=CC=CC=C4S3
Standard InChIKey VBVAVBCYMYWNOU-UHFFFAOYSA-N
Standard InChI InChI=1S/C20H18N2O2S/c1-3-22(4-2)14-10-9-13-11-15(20(23)24-17(13)12-14)19-21-16-7-5-6-8-18(16)25-19/h5-12H,3-4H2,1-2H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Coumarin VI

The

Biological Activity of Coumarin VI

DescriptionCoumarin VI is a fluorescent dye frequently used to facilitate the traceability of drug delivery systems in vitro.
In vitro

Coumarin 6 and 1,6-diphenyl-1,3,5-hexatriene (DPH) as fluorescent probes to monitor protein aggregation.[Pubmed: 21445407]

Analyst. 2011 May 21;136(10):2161-7.

We report the use of Coumarin 6(Coumarin VI) and 1,6-diphenyl-1,3,5-hexatriene (DPH) for the identification of protein aggregates for the first time. The two dyes can be used at very low (nanomolar) concentrations and do not interfere with the aggregation process, as is reported for other commonly used fluorescent protein probes. In the presence of protein aggregates, their quantum yields are significantly high. DPH is able to recognize both amorphous and fibrillar aggregates but cannot distinguish between them. Coumarin 6(Coumarin VI) can distinguish between both types of aggregates. It also exhibits the characteristic sigmoidal curve of amyloid formation, with higher sensitivity for detection of fibrillation than the conventionally used Thioflavin T.

Coumarin VI Dilution Calculator

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Coumarin VI Molarity Calculator

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Preparing Stock Solutions of Coumarin VI

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8536 mL 14.2678 mL 28.5356 mL 57.0711 mL 71.3389 mL
5 mM 0.5707 mL 2.8536 mL 5.7071 mL 11.4142 mL 14.2678 mL
10 mM 0.2854 mL 1.4268 mL 2.8536 mL 5.7071 mL 7.1339 mL
50 mM 0.0571 mL 0.2854 mL 0.5707 mL 1.1414 mL 1.4268 mL
100 mM 0.0285 mL 0.1427 mL 0.2854 mL 0.5707 mL 0.7134 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Coumarin VI

Coumarin 6 and 1,6-diphenyl-1,3,5-hexatriene (DPH) as fluorescent probes to monitor protein aggregation.[Pubmed:21445407]

Analyst. 2011 May 21;136(10):2161-7.

We report the use of Coumarin 6 and 1,6-diphenyl-1,3,5-hexatriene (DPH) for the identification of protein aggregates for the first time. The two dyes can be used at very low (nanomolar) concentrations and do not interfere with the aggregation process, as is reported for other commonly used fluorescent protein probes. In the presence of protein aggregates, their quantum yields are significantly high. DPH is able to recognize both amorphous and fibrillar aggregates but cannot distinguish between them. Coumarin 6 can distinguish between both types of aggregates. It also exhibits the characteristic sigmoidal curve of amyloid formation, with higher sensitivity for detection of fibrillation than the conventionally used Thioflavin T.

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