Bi-linderone

CAS# 1227375-09-8

Bi-linderone

2D Structure

Catalog No. BCN6116----Order now to get a substantial discount!

Product Name & Size Price Stock
Bi-linderone: 5mg $1225 In Stock
Bi-linderone: 10mg Please Inquire In Stock
Bi-linderone: 20mg Please Inquire Please Inquire
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Quality Control of Bi-linderone

3D structure

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Bi-linderone

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Chemical Properties of Bi-linderone

Cas No. 1227375-09-8 SDF Download SDF
PubChem ID 46848880 Appearance Yellow powder
Formula C34H32O10 M.Wt 600.6
Type of Compound Miscellaneous Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (6R,9R,10S)-9-[(3,4-dimethoxy-2,5-dioxocyclopent-3-en-1-ylidene)-methoxymethyl]-2,3,8-trimethoxy-6,10-diphenylspiro[4.5]deca-2,7-diene-1,4-dione
SMILES COC1=CC(C2(C(C1C(=C3C(=O)C(=C(C3=O)OC)OC)OC)C4=CC=CC=C4)C(=O)C(=C(C2=O)OC)OC)C5=CC=CC=C5
Standard InChIKey LCIXMPUYUMOMIA-JCTONOIOSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Bi-linderone

The roots of Lindera aggregata( Sims) Kosterm

Biological Activity of Bi-linderone

Description1. Bi-linderone shows significant activity against glucosamine-induced insulin resistance in HepG2 cells at a concentration of 1 microg/mL.

Bi-linderone Dilution Calculator

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Bi-linderone Molarity Calculator

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Preparing Stock Solutions of Bi-linderone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.665 mL 8.325 mL 16.65 mL 33.3 mL 41.625 mL
5 mM 0.333 mL 1.665 mL 3.33 mL 6.66 mL 8.325 mL
10 mM 0.1665 mL 0.8325 mL 1.665 mL 3.33 mL 4.1625 mL
50 mM 0.0333 mL 0.1665 mL 0.333 mL 0.666 mL 0.8325 mL
100 mM 0.0167 mL 0.0833 mL 0.1665 mL 0.333 mL 0.4163 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Bi-linderone

Bi-linderone, a highly modified methyl-linderone dimer from Lindera aggregata with activity toward improvement of insulin sensitivity in vitro.[Pubmed:20420414]

Org Lett. 2010 May 21;12(10):2354-7.

Bi-linderone (1) was isolated as racemate from the traditional Chinese medicinal plant Lindera aggregata. The structure elucidation of Bi-linderone was reported on the basis of extensive analysis of NMR spectra and crystal X-ray diffraction. Bi-linderone has an unprecedented spirocyclopentenedione-containing carbon skeleton and showed significant activity against glucosamine-induced insulin resistance in HepG2 cells at a concentration of 1 microg/mL.

Biomimetic total syntheses of linderaspirone A and bi-linderone and revisions of their biosynthetic pathways.[Pubmed:21446662]

Org Lett. 2011 May 6;13(9):2192-5.

Simple exposure to sunlight is sufficient for triggering photochemical [2 + 2] cycloaddition-Cope or radical rearrangement cascades in the naturally occurring methyl linderone, leading to efficient biomimetic total syntheses of linderaspirone A and Bi-linderone, two recently discovered bioactive spirocyclopentenedione natural products.

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