Caesalmin B

CAS# 352658-23-2

Caesalmin B

Catalog No. BCN7252----Order now to get a substantial discount!

Product Name & Size Price Stock
Caesalmin B: 5mg $960 In Stock
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Quality Control of Caesalmin B

Number of papers citing our products

Chemical structure

Caesalmin B

3D structure

Chemical Properties of Caesalmin B

Cas No. 352658-23-2 SDF Download SDF
PubChem ID 12037261 Appearance Powder
Formula C22H28O6 M.Wt 388.46
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC(=O)OC1CCC(C2(C1(C3CC4=C(C=CO4)C5C3C(C2)OC5=O)C)O)(C)C
Standard InChIKey GXBMHMVGIRRPBD-XTVZKPICSA-N
Standard InChI InChI=1S/C22H28O6/c1-11(23)27-16-5-7-20(2,3)22(25)10-15-18-13(21(16,22)4)9-14-12(6-8-26-14)17(18)19(24)28-15/h6,8,13,15-18,25H,5,7,9-10H2,1-4H3/t13-,15-,16-,17+,18-,21-,22+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Caesalmin B

The seed kernels of Caesalpinia crista.

Biological Activity of Caesalmin B

Description1. Caesalmin B shows significant dose-dependent inhibitory effects on Plasmodium falciparum FCR-3/A2 growth in vitro.
TargetsAntifection

Caesalmin B Dilution Calculator

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Caesalmin B Molarity Calculator

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Preparing Stock Solutions of Caesalmin B

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.5743 mL 12.8713 mL 25.7427 mL 51.4854 mL 64.3567 mL
5 mM 0.5149 mL 2.5743 mL 5.1485 mL 10.2971 mL 12.8713 mL
10 mM 0.2574 mL 1.2871 mL 2.5743 mL 5.1485 mL 6.4357 mL
50 mM 0.0515 mL 0.2574 mL 0.5149 mL 1.0297 mL 1.2871 mL
100 mM 0.0257 mL 0.1287 mL 0.2574 mL 0.5149 mL 0.6436 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Caesalmin B

Cassane- and norcassane-type diterpenes from Caesalpinia crista of Indonesia and their antimalarial activity against the growth of Plasmodium falciparum.[Pubmed:15921414]

J Nat Prod. 2005 May;68(5):706-10.

The CH2Cl2 extract of the seed kernels of Caesalpinia crista, which exhibited promising antimalarial activity against Plasmodium berghei-infected mice in vivo, was examined and resulted in the isolation of seven new furanocassane-type diterpenes [caesalpinins C-G (1-5) and norcaesalpinins D and E (6, 7)] together with norcaesalpinins A-C (8-10) and 11 known compounds (norcaesalpinins A-C, 2-acetoxy-3-deacetoxycaesaldekarin e, Caesalmin B, caesaldekarin e, caesalpin F, 14(17)-dehydrocaesalpin F, 2-acetoxycaesaldekarin e, 7-acetoxybonducellpin C, and caesalmin G). Their structures were determined on the basis of spectroscopic analysis. The isolated diterpenes showed significant dose-dependent inhibitory effects on Plasmodium falciparum FCR-3/A2 growth in vitro. Their IC50 values ranged from 90 nM to 6.5 microM, and norcaesalpinin E (7) showed the most potent inhibitory activity (IC50, 90 nM).

Cassane- and norcassane-type diterpenes of Caesalpinia crista from Myanmar.[Pubmed:15568776]

J Nat Prod. 2004 Nov;67(11):1859-63.

From the CH(2)Cl(2) extract of seed kernels of Caesalpinia crista from Myanmar, five new cassane-type diterpenes, caesalpinins MA-ME (1-5), and three new norcassane-type diterpenes, norcaesalpinins MA-MC (6-8), have been isolated, together with 12 known cassane-type diterpenes, 14(17)-dehydrocaesalmin F, caesaldekarin e, Caesalmin B, caesalmin C, caesalmin E, 2-acetoxy-3-deacetoxycaesaldekarin e, 2-acetoxycaesaldekarin e, caesalpinin C, 7-acetoxybonducellpin C, caesalpinin E, norcaesalpinin B, and 6-acetoxy-3-deacetoxycaesaldekarin e. The structures of the isolated compounds were elucidated by analysis of their spectroscopic data.

Molecular structures and antiviral activities of naturally occurring and modified cassane furanoditerpenoids and friedelane triterpenoids from Caesalpinia minax.[Pubmed:11983512]

Bioorg Med Chem. 2002 Jul;10(7):2161-70.

Further investigation of the active components of the chloroform fraction of the seeds of Caesalpinia minax led to the isolation of a new cassane furanoditerpenoid, caesalmin H (1), together with two known furanoditerpenoid lactones, Caesalmin B (2) and bonducellpin D (3). Reduction of the naturally abundant caesalmin D (9), E (10) and F (11) resulted in three new furanoditerpenoid derivatives 4-6. Phytochemical study of the stem of the same plant and subsequent reduction afforded two friedelane triterpenoids (7-8), which were identified by spectroscopic methods. Compounds 1-2 and 4-8 were corroborated by single crystal X-ray analysis. The factors governing the reduction of cassane furanoditerpenoids and friedelane triterpenoids were investigated by correlating the crystallographic results with density functional theory. The inhibitory activities of 2-8 on the Para3 virus were evaluated by cytopathogenic effects (CPE) reduction assay.

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