Home >> Research Area >>Vitamin D Related>>VD/VDR>> Calcifediol-D6

Calcifediol-D6

Deuterated form of Calcifediol CAS# 78782-98-6

Calcifediol-D6

Catalog No. BCC4075----Order now to get a substantial discount!

Product Name & Size Price Stock
Calcifediol-D6: 5mg $5325 In Stock
Calcifediol-D6: 10mg Please Inquire In Stock
Calcifediol-D6: 20mg Please Inquire Please Inquire
Calcifediol-D6: 50mg Please Inquire Please Inquire
Calcifediol-D6: 100mg Please Inquire Please Inquire
Calcifediol-D6: 200mg Please Inquire Please Inquire
Calcifediol-D6: 500mg Please Inquire Please Inquire
Calcifediol-D6: 1000mg Please Inquire Please Inquire
Related Products
  • IPI-145 (INK1197)

    Catalog No.:BCC1104
    CAS No.:1201438-56-3
  • IC-87114

    Catalog No.:BCC1161
    CAS No.:371242-69-2
  • PI-103

    Catalog No.:BCC1162
    CAS No.:371935-74-9
  • PIK-75

    Catalog No.:BCC1163
    CAS No.:372196-77-5
  • TGX-221

    Catalog No.:BCC1244
    CAS No.:663619-89-4

Quality Control of Calcifediol-D6

Number of papers citing our products

Chemical structure

Calcifediol-D6

3D structure

Chemical Properties of Calcifediol-D6

Cas No. 78782-98-6 SDF Download SDF
PubChem ID 66577010 Appearance Powder
Formula C27H44O2 M.Wt 400.6
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in DMSO
Chemical Name (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-7,7,7-trideuterio-6-hydroxy-6-(trideuteriomethyl)heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol
SMILES CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C
Standard InChIKey JWUBBDSIWDLEOM-QFVHMXLQSA-N
Standard InChI InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1/i3D3,4D3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Calcifediol-D6

DescriptionCalcifediol-D6 is the deuterated form of Calcifediol(25-hydroxy Vitamin D3), which is a prehormone that is produced in the liver by hydroxylation of vitamin D3 (cholecalciferol) by the enzyme cholecalciferol 25-hydroxylase IC50 value: Target: This metabolite is being measured by physicians worldwide to determine a patient's vitamin d status.Calcifediol is then converted in the kidneys (by the enzyme 25(OH)D-1α-hydroxylase) into calcitriol (1,25-(OH)2D3), a secosteroid hormone that is the active form of vitamin D. It can also be converted into 24-hydroxycalcidiol in the kidneys via 24-hydroxylation.

References:
[1]. Teitelbaum SL. Calcifediol (25-hydroxyvitamin D3) in the treatment of uremic bone disease. Ann Intern Med. 1981 Mar;94(3):404-5. [2]. Kleinman LM, Letteri JM, Asad SN, Ellis KJ, Cohn SH. Effects of calcifediol on calcified tissue in uremia. Arch Intern Med. 1978 May 15;138 Spec No:864-5. [3]. Recker R, Schoenfeld P, Letteri J, Slatopolsky E, Goldsmith R, Brickman A. The efficacy of calcifediol in renal osteodystrophy. Arch Intern Med. 1978 May 15;138 Spec No:857-63. [4]. Teitelbaum SL, Bone JM, Stein PM, Gilden JJ, Bates M, Boisseau VC, Avioli LV. Calcifediol in chronic renal insufficiency. Skeletal response. JAMA. 1976 Jan 12;235(2):164-7.

Calcifediol-D6 Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Calcifediol-D6 Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Calcifediol-D6

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4963 mL 12.4813 mL 24.9626 mL 49.9251 mL 62.4064 mL
5 mM 0.4993 mL 2.4963 mL 4.9925 mL 9.985 mL 12.4813 mL
10 mM 0.2496 mL 1.2481 mL 2.4963 mL 4.9925 mL 6.2406 mL
50 mM 0.0499 mL 0.2496 mL 0.4993 mL 0.9985 mL 1.2481 mL
100 mM 0.025 mL 0.1248 mL 0.2496 mL 0.4993 mL 0.6241 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University

Background on Calcifediol-D6

Calcifediol-D6 is the deuterated form of Calcifediol (25-hydroxy Vitamin D3). Calcifediol is a prehormone that is a major circulating metabolite of vitamin D3.

In vitro: Calcifediol acted as a competitive inhibitor with an apparent Ki value of 3.9 μM. It also inhibited PTH secretion and mRNA with ED50 value of 2 nM.

In vivo: Oral calcifediol (biweekly or monthly regimens) was effective and safe in improving blood 25(OH)D levels and in decreasing PTH in kidney transplant recipients [1]. Calcifediol administration improved lipid profile in osteopenic atorvastatin-treated postmenopausal women [2].

Clinical trial: Correct calcium intake plus calcifediol (15 μg/day if bodyweight <20 kg; 25 μg>30 kg; oral administration) can improve bone mineral density in some young patients with cystic fibrosis [3]. Modified-release (MR) formulation of calcifediol (30, 60 or 90 μg; oral administration) was safe and highly effective in treating secondary hyperparathyroidism associated with vitamin D insufficiency in chronic kidney disease [4]. Calcifediol (20 μg) improved gait speed in young postmenopausal women compared with vitamin D3 (20 μg) [5].

References:
1.  Barros X, Rodriguez NY, Fuster D, Rodas L, Esforzado N, Mazza A, et al. Comparison of two different vitamin D supplementation regimens with oral calcifediol in kidney transplant patients. J Nephrol. 2015.
2.  Catalano A, Morabito N, Basile G, Cucinotta D, Lasco A. Calcifediol improves lipid profile in osteopenicatorvastatin-treated postmenopausal women. Eur J Clin Invest. 2015;45(2):144-9.
3.  Bianchi ML, Colombo C, Assael BM, Dubini A, Lombardo M, Quattrucci S, et al. Treatment of low bone density in young people with cystic fibrosis: a multicentre, prospective, open-label observational study of calcium and calcifediol followed by a randomised placebo-controlled trial of alendronate. Lancet Respir Med. 2013;1(5):377-85.
4.  Sprague SM, Silva AL, Al-Saghir F, Damle R, Tabash SP, Petkovich M, et al. Modified-release calcifediol effectively controls secondary hyperparathyroidism associated with vitamin D insufficiency in chronic kidney disease. Am J Nephrol. 2014;40(6):535-45.
5.  Meyer O, Dawson-Hughes B, Sidelnikov E, Egli A, Grob D, Staehelin HB, et al. Calcifediol versus vitamin D3 effects on gait speed and trunk sway in young postmenopausal women: a double-blind randomized controlled trial. Osteoporos Int. 2015;26(1):373-81.

Featured Products
New Products
 

Description

Calcifediol-D6 is the deuterated form of Calcifediol(25-hydroxy Vitamin D3), which is a prehormone that is produced in the liver by hydroxylation of vitamin D3 (cholecalciferol) by the enzyme cholecalciferol 25-hydroxylase.

Keywords:

Calcifediol-D6,78782-98-6,Natural Products,VD/VDR, buy Calcifediol-D6 , Calcifediol-D6 supplier , purchase Calcifediol-D6 , Calcifediol-D6 cost , Calcifediol-D6 manufacturer , order Calcifediol-D6 , high purity Calcifediol-D6

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: