Calebassine

CAS# 7257-29-6

Calebassine

Catalog No. BCN2276----Order now to get a substantial discount!

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Quality Control of Calebassine

Number of papers citing our products

Chemical structure

Calebassine

3D structure

Chemical Properties of Calebassine

Cas No. 7257-29-6 SDF Download SDF
PubChem ID 90476310 Appearance Powder
Formula C42H52N4O2 M.Wt 644.9
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (1S,10R,11R,12R,14S,18S,27R,28R,29R,30E,35S,37R,38R,40E)-30,40-di(ethylidene)-15,32-dimethyl-9,26-diaza-15,32-diazoniadodecacyclo[27.5.2.212,15.11,28.111,18.03,8.010,27.014,18.020,25.032,35.09,37.026,38]tetraconta-3,5,7,20,22,24-hexaene-37,38-diol
SMILES CC=C1C[N+]2(CCC34C2CC1C5C3(N(C6C5N7C8=CC=CC=C8CC91C7(C6C2CC9[N+](CC1)(CC2=CC)C)O)C1=CC=CC=C1C4)O)C
Standard InChIKey WMAARYDWTZONIK-WZIFSCQFSA-N
Standard InChI InChI=1S/C42H52N4O2/c1-5-25-23-45(3)17-15-39-21-27-11-8-10-14-32(27)44-38-36-30-20-34-40(16-18-46(34,4)24-26(30)6-2)22-28-12-7-9-13-31(28)43(42(36,40)48)37(38)35(41(39,44)47)29(25)19-33(39)45/h5-14,29-30,33-38,47-48H,15-24H2,1-4H3/q+2/b25-5-,26-6-/t29-,30-,33-,34-,35+,36+,37+,38+,39+,40+,41+,42+,45?,46?/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Calebassine

The seeds of Strychnos nux-vomica Linn.

Biological Activity of Calebassine

Description1. Calebassine is a competitive neuromuscular blocking agent. 2. Calebassine is a Mdm2/MdmX inhibitor.

Calebassine Dilution Calculator

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Calebassine Molarity Calculator

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Preparing Stock Solutions of Calebassine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.5506 mL 7.7531 mL 15.5063 mL 31.0126 mL 38.7657 mL
5 mM 0.3101 mL 1.5506 mL 3.1013 mL 6.2025 mL 7.7531 mL
10 mM 0.1551 mL 0.7753 mL 1.5506 mL 3.1013 mL 3.8766 mL
50 mM 0.031 mL 0.1551 mL 0.3101 mL 0.6203 mL 0.7753 mL
100 mM 0.0155 mL 0.0775 mL 0.1551 mL 0.3101 mL 0.3877 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Calebassine

Chemical structure and pharmacological (curarizing) properties of various indole alkaloids extracted from an African Strychnos.[Pubmed:126050]

Arch Int Pharmacodyn Ther. 1975 Jun;215(2):246-58.

The chemical separation and identification of ten alkaloids extracted from the roots of Strychnos usambarensis are described. The elucidation of their structure by means of elementary analysis, I. R., U.V, and mass spectrometry allows their classification into bistertiary amines, hybrid and bisquaternary ammonium derivatives. This classification is reflected in the pharmacological properties. One of the tertiary amine alkaloids (usambarensine) presents atopine-like and spasmolytic activities while the bisquaternary ammonium compounds (dihydrotoxiferine, Calebassine, C-curarine and afrocurarine) are competitive neuromuscular blocking agents.

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