Chelidonic acid

CAS# 99-32-1

Chelidonic acid

Catalog No. BCN6547----Order now to get a substantial discount!

Product Name & Size Price Stock
Chelidonic acid: 5mg $23 In Stock
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Quality Control of Chelidonic acid

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Chemical structure

Chelidonic acid

3D structure

Chemical Properties of Chelidonic acid

Cas No. 99-32-1 SDF Download SDF
PubChem ID 7431 Appearance Faintly red powder
Formula C7H4O6 M.Wt 184.10
Type of Compound Miscellaneous Storage Desiccate at -20°C
Synonyms Jerva acid; Jervaic acid; Jervasic acid
Solubility Soluble in hot water
Chemical Name 4-oxopyran-2,6-dicarboxylic acid
SMILES C1=C(OC(=CC1=O)C(=O)O)C(=O)O
Standard InChIKey PBAYDYUZOSNJGU-UHFFFAOYSA-N
Standard InChI InChI=1S/C7H4O6/c8-3-1-4(6(9)10)13-5(2-3)7(11)12/h1-2H,(H,9,10)(H,11,12)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Chelidonic acid

The herbs of Chelidonium majus

Biological Activity of Chelidonic acid

Description1. Chelidonic acid has therapeutic potential in allergic disorders, it can reduce the levels of the blood eosinophil counts and serum IgE and inhibit histamine release from rat peritoneal mast cells (RPMC) in vitro. 2. Chelidonic acid has shown anti-inflammatory effects, it also can evoke antidepressant-like effect through the up-regulation of BDNF in forced swimming test.
Targets5-HT Receptor | Adrenergic Receptor | Dopamine Receptor

Chelidonic acid Dilution Calculator

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Chelidonic acid Molarity Calculator

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Preparing Stock Solutions of Chelidonic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.4318 mL 27.1592 mL 54.3183 mL 108.6366 mL 135.7958 mL
5 mM 1.0864 mL 5.4318 mL 10.8637 mL 21.7273 mL 27.1592 mL
10 mM 0.5432 mL 2.7159 mL 5.4318 mL 10.8637 mL 13.5796 mL
50 mM 0.1086 mL 0.5432 mL 1.0864 mL 2.1727 mL 2.7159 mL
100 mM 0.0543 mL 0.2716 mL 0.5432 mL 1.0864 mL 1.358 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Chelidonic acid

Chelidonic acid evokes antidepressant-like effect through the up-regulation of BDNF in forced swimming test.[Pubmed:27037280]

Exp Biol Med (Maywood). 2016 Aug;241(14):1559-67.

Depression is usually accompanied by neuro-inflammatory reactions. Chelidonic acid, in particular, has shown anti-inflammatory effects. The objective of this study was to evaluate the anti-depressant effects of Chelidonic acid and to discuss the potential mechanisms of a forced swimming test. Chelidonic acid was administered orally once a day for 14 days. On the 14th day, Chelidonic acid resulted in a significant decrease in immobility time during the forced swimming test without alteration of locomotor activity, in an open field test. Chelidonic acid also increased the number of nissl bodies in the hippocampus. Brain-derived neurotrophic factor expression and extracellular signal-regulated protein kinase phosphorylation in the hippocampus were up-regulated by the administration of Chelidonic acid. Chelidonic acid administration significantly increased the mRNA expression of hippocampal estrogen receptor-beta. The levels of hippocampal interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha were effectively attenuated by the administration of Chelidonic acid. In addition, Chelidonic acid significantly increased the levels of 5-hydroxytryptamine (serotonin), dopamine, and norepinephrine compared with those levels for the mice that were administered distilled water in the hippocampus. These results suggest that Chelidonic acid might serve as a new therapeutic strategy for the regulation of depression associated with inflammation.

Effects of chelidonic acid, a secondary plant metabolite, on mast cell degranulation and adaptive immunity in rats.[Pubmed:27620504]

Int Immunopharmacol. 2016 Nov;40:229-234.

The present study evaluated the immunomodulatory effects of Chelidonic acid, a secondary plant metabolite, with therapeutic potential in allergic disorders, in experimental animals. In mast cell degranulation studies, ovalbumin immunized and challenged rats, Chelidonic acid (1, 3 and 10mg/kg, i.p.) dose relatedly prevented ovalbumin challenge induced mast cell degranulation by differing degrees when compared with vehicle treated group, and these effects were comparable with prednisolone (10mg/kg). A reduction in post-challenge mortality was also observed in all treated groups. Further, there were reductions in the blood eosinophil counts and serum IgE levels after Chelidonic acid treatment. Chelidonic acid also inhibited histamine release from rat peritoneal mast cells (RPMC) in vitro, in a dose related manner. In tests for adaptive immunity, in rats immunized with sheep RBC, Chelidonic acid differentially suppressed the (a) plaque forming cell (PFC) count in rat splenic cells, (b) anti-SRBC antibody titre and serum IgG levels and (c) increases in foot pad thickness in the DTH assay - all of which were comparable with prednisolone. These experimental results are discussed in light of the possible therapeutic potential of Chelidonic acid in allergic disorders.

Description

Chelidonic acid is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1. Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM.

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