Chelidonic acidCAS# 99-32-1 |
Quality Control & MSDS
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Number of papers citing our products
| Cas No. | 99-32-1 | SDF | Download SDF |
| PubChem ID | 7431 | Appearance | Faintly red powder |
| Formula | C7H4O6 | M.Wt | 184.10 |
| Type of Compound | Miscellaneous | Storage | Desiccate at -20°C |
| Synonyms | Jerva acid; Jervaic acid; Jervasic acid | ||
| Solubility | Soluble in hot water | ||
| Chemical Name | 4-oxopyran-2,6-dicarboxylic acid | ||
| SMILES | C1=C(OC(=CC1=O)C(=O)O)C(=O)O | ||
| Standard InChIKey | PBAYDYUZOSNJGU-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C7H4O6/c8-3-1-4(6(9)10)13-5(2-3)7(11)12/h1-2H,(H,9,10)(H,11,12) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Chelidonic acid has therapeutic potential in allergic disorders, it can reduce the levels of the blood eosinophil counts and serum IgE and inhibit histamine release from rat peritoneal mast cells (RPMC) in vitro. 2. Chelidonic acid has shown anti-inflammatory effects, it also can evoke antidepressant-like effect through the up-regulation of BDNF in forced swimming test. |
| Targets | 5-HT Receptor | Adrenergic Receptor | Dopamine Receptor |
Chelidonic acid Dilution Calculator
Chelidonic acid Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 5.4318 mL | 27.1592 mL | 54.3183 mL | 108.6366 mL | 135.7958 mL |
| 5 mM | 1.0864 mL | 5.4318 mL | 10.8637 mL | 21.7273 mL | 27.1592 mL |
| 10 mM | 0.5432 mL | 2.7159 mL | 5.4318 mL | 10.8637 mL | 13.5796 mL |
| 50 mM | 0.1086 mL | 0.5432 mL | 1.0864 mL | 2.1727 mL | 2.7159 mL |
| 100 mM | 0.0543 mL | 0.2716 mL | 0.5432 mL | 1.0864 mL | 1.358 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Chelidonic acid evokes antidepressant-like effect through the up-regulation of BDNF in forced swimming test.[Pubmed:27037280]
Exp Biol Med (Maywood). 2016 Aug;241(14):1559-67.
Depression is usually accompanied by neuro-inflammatory reactions. Chelidonic acid, in particular, has shown anti-inflammatory effects. The objective of this study was to evaluate the anti-depressant effects of Chelidonic acid and to discuss the potential mechanisms of a forced swimming test. Chelidonic acid was administered orally once a day for 14 days. On the 14th day, Chelidonic acid resulted in a significant decrease in immobility time during the forced swimming test without alteration of locomotor activity, in an open field test. Chelidonic acid also increased the number of nissl bodies in the hippocampus. Brain-derived neurotrophic factor expression and extracellular signal-regulated protein kinase phosphorylation in the hippocampus were up-regulated by the administration of Chelidonic acid. Chelidonic acid administration significantly increased the mRNA expression of hippocampal estrogen receptor-beta. The levels of hippocampal interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha were effectively attenuated by the administration of Chelidonic acid. In addition, Chelidonic acid significantly increased the levels of 5-hydroxytryptamine (serotonin), dopamine, and norepinephrine compared with those levels for the mice that were administered distilled water in the hippocampus. These results suggest that Chelidonic acid might serve as a new therapeutic strategy for the regulation of depression associated with inflammation.
Effects of chelidonic acid, a secondary plant metabolite, on mast cell degranulation and adaptive immunity in rats.[Pubmed:27620504]
Int Immunopharmacol. 2016 Nov;40:229-234.
The present study evaluated the immunomodulatory effects of Chelidonic acid, a secondary plant metabolite, with therapeutic potential in allergic disorders, in experimental animals. In mast cell degranulation studies, ovalbumin immunized and challenged rats, Chelidonic acid (1, 3 and 10mg/kg, i.p.) dose relatedly prevented ovalbumin challenge induced mast cell degranulation by differing degrees when compared with vehicle treated group, and these effects were comparable with prednisolone (10mg/kg). A reduction in post-challenge mortality was also observed in all treated groups. Further, there were reductions in the blood eosinophil counts and serum IgE levels after Chelidonic acid treatment. Chelidonic acid also inhibited histamine release from rat peritoneal mast cells (RPMC) in vitro, in a dose related manner. In tests for adaptive immunity, in rats immunized with sheep RBC, Chelidonic acid differentially suppressed the (a) plaque forming cell (PFC) count in rat splenic cells, (b) anti-SRBC antibody titre and serum IgG levels and (c) increases in foot pad thickness in the DTH assay - all of which were comparable with prednisolone. These experimental results are discussed in light of the possible therapeutic potential of Chelidonic acid in allergic disorders.
