LimonolCAS# 989-61-7 |
Quality Control & MSDS
3D structure
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Number of papers citing our products
| Cas No. | 989-61-7 | SDF | Download SDF |
| PubChem ID | 3083667 | Appearance | Powder |
| Formula | C26H32O8 | M.Wt | 472.5 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC1(C2CC(C3(C(C24COC(=O)CC4O1)CCC5(C36C(O6)C(=O)OC5C7=COC=C7)C)C)O)C | ||
| Standard InChIKey | ZFIURKZEANVFML-GJXGUZPUSA-N | ||
| Standard InChI | InChI=1S/C26H32O8/c1-22(2)15-9-16(27)24(4)14(25(15)12-31-18(28)10-17(25)33-22)5-7-23(3)19(13-6-8-30-11-13)32-21(29)20-26(23,24)34-20/h6,8,11,14-17,19-20,27H,5,7,9-10,12H2,1-4H3/t14?,15?,16?,17?,19-,20?,23-,24?,25?,26?/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Limonol-derivatives could as promising scaffolds for the design of novel Hsp90α inhibitors. |
| Targets | Raf | ATPase | Akt | HSP (e.g. HSP90) |
Limonol Dilution Calculator
Limonol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.1164 mL | 10.582 mL | 21.164 mL | 42.328 mL | 52.9101 mL |
| 5 mM | 0.4233 mL | 2.1164 mL | 4.2328 mL | 8.4656 mL | 10.582 mL |
| 10 mM | 0.2116 mL | 1.0582 mL | 2.1164 mL | 4.2328 mL | 5.291 mL |
| 50 mM | 0.0423 mL | 0.2116 mL | 0.4233 mL | 0.8466 mL | 1.0582 mL |
| 100 mM | 0.0212 mL | 0.1058 mL | 0.2116 mL | 0.4233 mL | 0.5291 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Antifungal activity of some tetranortriterpenoids.[Pubmed:10844171]
Fitoterapia. 2000 Jun;71(3):317-20.
Natural tetranortriterpenoids such as cedrelone from Toona ciliata, azadiradione from Azadirachta indica, limonin, Limonol and nomilinic acid from Citrus medica, along with some cedrelone derivatives were tested for their antifungal activity against Puccinia arachidis, a groundnut rust pathogen. Results show that cedrelone was the most effective in reducing rust pustule emergence. Replacement of functional groups or modification of the A or the B ring in cedrelone reduced the effectiveness indicating the importance of specific structural features for activity.
Identification of Limonol Derivatives as Heat Shock Protein 90 (Hsp90) Inhibitors through a Multidisciplinary Approach.[Pubmed:27492719]
Chemistry. 2016 Sep 5;22(37):13236-50.
The identification of inhibitors of Hsp90 is currently a primary goal in the development of more effective drugs for the treatment of various types of multidrug resistant malignancies. In an attempt to identify new small molecules modulating the activity of Hsp90, we screened a small library of tetranortriterpenes. A high-affinity interaction with Hsp90 inducible form was uncovered for eight of these compounds, five of which are described here for the first time. By monitoring the ATPase activity and the citrate synthase thermal induced aggregation, compound 1 (cedrelosin A), 3 (7alpha-limonylacetate), and 5 (cedrelosin B), containing a Limonol moiety, were found to be the most effective in compromising the Hsp90alpha chaperone activity. Consistent with these findings, the three compounds caused a depletion of c-Raf and pAkt Hsp90 client proteins in HeLa and MCF/7 cell lines. Induced fit docking protocol and molecular dynamics were used to rationalize the structural basis of the biological activity of the Limonol derivatives. Taken together, these results point to Limonol-derivatives as promising scaffolds for the design of novel Hsp90alpha inhibitors.
