IsothymusinCAS# 98755-25-0 |
Quality Control & MSDS
3D structure
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| Cas No. | 98755-25-0 | SDF | Download SDF |
| PubChem ID | 630253 | Appearance | Yellow powder |
| Formula | C17H14O7 | M.Wt | 330.3 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 5,8-dihydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxychromen-4-one | ||
| SMILES | COC1=C(C2=C(C(=C1OC)O)OC(=CC2=O)C3=CC=C(C=C3)O)O | ||
| Standard InChIKey | IODGQWWTJYDCLN-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C17H14O7/c1-22-16-13(20)12-10(19)7-11(8-3-5-9(18)6-4-8)24-15(12)14(21)17(16)23-2/h3-7,18,20-21H,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Isothymusin( MIC= 200 microg/mL)exhibits inhibition activity against Mycobacterium tuberculosis. 2. Isothymusin( IC50=7.7 microg/mL )exhibits antioxidant activity against the radical scavenging ability of DPPH. |
| Targets | Antifection |
Isothymusin Dilution Calculator
Isothymusin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.0276 mL | 15.1378 mL | 30.2755 mL | 60.551 mL | 75.6888 mL |
| 5 mM | 0.6055 mL | 3.0276 mL | 6.0551 mL | 12.1102 mL | 15.1378 mL |
| 10 mM | 0.3028 mL | 1.5138 mL | 3.0276 mL | 6.0551 mL | 7.5689 mL |
| 50 mM | 0.0606 mL | 0.3028 mL | 0.6055 mL | 1.211 mL | 1.5138 mL |
| 100 mM | 0.0303 mL | 0.1514 mL | 0.3028 mL | 0.6055 mL | 0.7569 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Antimycobacterial and antioxidant flavones from Limnophila geoffrayi.[Pubmed:14609129]
Arch Pharm Res. 2003 Oct;26(10):816-20.
The chloroform extract of the aerial part of Limnophila geoffrayi showed antimycobacterial and antioxidant activities. Bioassay-guided fractionation has led to the isolation of the flavones nevadensin (5,7-dihydroxy-6,8,4'-trimethoxyflavone, 1) and Isothymusin (6,7-dimethoxy-5,8,4'-trihydroxyflavone, 2). Both compounds 1 and 2 exhibited inhibition activity against Mycobacterium tuberculosis, with equal MIC value of 200 microg/mL. Only compound 2 exhibited antioxidant activity against the radical scavenging ability of DPPH, with the IC50 value of 7.7 microg/mL. The crude hexane, chloroform and methanol extracts as well as the pure compounds 1 and 2 did not exhibit mutagenic activity in the Bacillus subtilis recassay.
An 8-hydroxylated external flavone and its 8-O-glucoside from Becium grandiflorum.[Pubmed:9542170]
Phytochemistry. 1998 Mar;47(5):779-82.
The major vacuolar flavonoid of a greenhouse-grown plant of Becium grandiflorum has been identified as the 8-O-glucoside of Isothymusin (5,8,4'-trihydroxy-6,7-dimethoxyflavone), while the major external flavonoids in the diethyl ether surface wash of the same plant are found to be Isothymusin and cirsimaritin (5,4'-dihydroxy-7,8-dimethoxyflavone). Although Isothymusin is already known as a conversion product of thymusin (5,6,4'-trihydroxy-6,7-dimethoxyflavone) formed by means of the Wessely-Moser rearrangement, this is the first report of Isothymusin as a plant constituent, both as aglycone and glycoside. The biogenetic and chemotaxonomic implications of the occurrence of these flavonoids in B.grandiflorum are briefly discussed.
