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Ropivacaine HCl

CAS# 98717-15-8

Ropivacaine HCl

Catalog No. BCC4841----Order now to get a substantial discount!

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Ropivacaine HCl: 5mg $17 In Stock
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Chemical structure

Ropivacaine HCl

3D structure

Chemical Properties of Ropivacaine HCl

Cas No. 98717-15-8 SDF Download SDF
PubChem ID 175804 Appearance Powder
Formula C17H27ClN2O M.Wt 310.86
Type of Compound N/A Storage Desiccate at -20°C
Solubility DMSO : 10 mg/mL (32.17 mM; Need ultrasonic)
H2O : 10 mg/mL (32.17 mM; Need ultrasonic)
Chemical Name (2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide;hydrochloride
SMILES [Cl-].CCCN1CCCC[C@H]1C(=O)Nc2c(C)cccc2C.[H+]
Standard InChIKey NDNSIBYYUOEUSV-RSAXXLAASA-N
Standard InChI InChI=1S/C17H26N2O.ClH/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3;/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20);1H/t15-;/m0./s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Ropivacaine HCl Dilution Calculator

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Ropivacaine HCl Molarity Calculator

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Preparing Stock Solutions of Ropivacaine HCl

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2169 mL 16.0844 mL 32.1688 mL 64.3376 mL 80.4221 mL
5 mM 0.6434 mL 3.2169 mL 6.4338 mL 12.8675 mL 16.0844 mL
10 mM 0.3217 mL 1.6084 mL 3.2169 mL 6.4338 mL 8.0422 mL
50 mM 0.0643 mL 0.3217 mL 0.6434 mL 1.2868 mL 1.6084 mL
100 mM 0.0322 mL 0.1608 mL 0.3217 mL 0.6434 mL 0.8042 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Ropivacaine HCl

Ropivacaine HCl is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.

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References on Ropivacaine HCl

Crystal structure and physical properties of two polymorphs of ropivacaine HCl.[Pubmed:16447177]

J Pharm Sci. 2006 Mar;95(3):680-8.

The crystal structure of two polymorphs of Ropivacaine HCl have been determined, as well as their relative stability up to 100 degrees C. A geometric restriction for a solid-state transition between the two polymorphs has been identified. The packing density along the H-bonded chains form the basis for a model explaining the kinetic crystallization of the metastable form. The difference in stability and physicochemical properties between the two polymorphs can be attributed to the difference in crystal structure.

Description

Ropivacaine hydrochloride is an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM.

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