Ganoderic acid FCAS# 98665-14-6 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 98665-14-6 | SDF | Download SDF |
| PubChem ID | 23247895 | Appearance | White-yellowish powder |
| Formula | C32H42O9 | M.Wt | 570.7 |
| Type of Compound | Isoprenoids | Storage | Desiccate at -20°C |
| Synonyms | 98665-15-7 | ||
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (6R)-6-[(5R,10S,12S,13R,14R,17R)-12-acetyloxy-4,4,10,13,14-pentamethyl-3,7,11,15-tetraoxo-2,5,6,12,16,17-hexahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxoheptanoic acid | ||
| SMILES | CC(CC(=O)CC(C)C(=O)O)C1CC(=O)C2(C1(C(C(=O)C3=C2C(=O)CC4C3(CCC(=O)C4(C)C)C)OC(=O)C)C)C | ||
| Standard InChIKey | BWCNWXLKMWWVBT-AIMUVTGPSA-N | ||
| Standard InChI | InChI=1S/C32H42O9/c1-15(11-18(34)12-16(2)28(39)40)19-13-23(37)32(8)24-20(35)14-21-29(4,5)22(36)9-10-30(21,6)25(24)26(38)27(31(19,32)7)41-17(3)33/h15-16,19,21,27H,9-14H2,1-8H3,(H,39,40)/t15-,16?,19-,21+,27-,30+,31+,32+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Ganoderic acid F has anti-hepatitis B, anti-inflammatory, and anti-tumor-promoting activities. |
| Targets | HBV | Immunology & Inflammation related |
| In vivo | Pharmacokinetics of ganoderic acids a and f after oral administration of ling zhi preparation in healthy male volunteers.[Pubmed: 22577465]Evid Based Complement Alternat Med. 2012;2012:780892.The objectives of this paper were to evaluate the pharmacokinetics of ganoderic acid A and Ganoderic acid F after a single oral dose of the water extract of MG2-strain Ling Zhi (MG2FB-WE) and to assess the influence of food on the pharmacokinetics in 12 healthy male volunteers.
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Ganoderic acid F Dilution Calculator
Ganoderic acid F Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.7522 mL | 8.7612 mL | 17.5223 mL | 35.0447 mL | 43.8059 mL |
| 5 mM | 0.3504 mL | 1.7522 mL | 3.5045 mL | 7.0089 mL | 8.7612 mL |
| 10 mM | 0.1752 mL | 0.8761 mL | 1.7522 mL | 3.5045 mL | 4.3806 mL |
| 50 mM | 0.035 mL | 0.1752 mL | 0.3504 mL | 0.7009 mL | 0.8761 mL |
| 100 mM | 0.0175 mL | 0.0876 mL | 0.1752 mL | 0.3504 mL | 0.4381 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Pharmacokinetics of ganoderic acids a and f after oral administration of ling zhi preparation in healthy male volunteers.[Pubmed:22577465]
Evid Based Complement Alternat Med. 2012;2012:780892.
The objectives of this paper were to evaluate the pharmacokinetics of ganoderic acids A and F after a single oral dose of the water extract of MG2-strain Ling Zhi (MG2FB-WE) and to assess the influence of food on the pharmacokinetics in 12 healthy male volunteers. This study was a single-dose, open-label, randomized, two-phase crossover study with at least 2 wk washout period. Each subject was randomly assigned to receive a single oral dose of 3,000 mg of MG2FB-WE in granular formulation dissolved in 200 mL of warm water, either under a fasting condition, or immediately after a standard breakfast (fed condition). Blood samples were collected immediately before and at specific time points until 8 h after MG2FB-WE administration. Plasma ganoderic acids A and F concentrations were determined by using liquid chromatography-mass spectrometry (LC-MS) technique. In conclusion, the pharmacokinetic profile of both ganoderic acids under a fasting condition was characterized by rapid absorption from the gastrointestinal tract (T(max) at approximately 30 min) and a short elimination half-life (<40 min). Food significantly decreased C(max) and delayed T(max), but did not affect the extent of ganoderic acid A absorption. However, concomitant food intake markedly impeded both rate and extent of Ganoderic acid F absorption.
