Home >> Research Area >>Natural Products>>Isoprenoids>> Ganoderic acid F

Ganoderic acid F

CAS# 98665-14-6

Ganoderic acid F

Catalog No. BCN3037----Order now to get a substantial discount!

Product Name & Size Price Stock
Ganoderic acid F: 5mg Please Inquire In Stock
Ganoderic acid F: 10mg Please Inquire In Stock
Ganoderic acid F: 20mg Please Inquire Please Inquire
Ganoderic acid F: 50mg Please Inquire Please Inquire
Ganoderic acid F: 100mg Please Inquire Please Inquire
Ganoderic acid F: 200mg Please Inquire Please Inquire
Ganoderic acid F: 500mg Please Inquire Please Inquire
Ganoderic acid F: 1000mg Please Inquire Please Inquire

Quality Control of Ganoderic acid F

Number of papers citing our products

Chemical structure

Ganoderic acid F

3D structure

Chemical Properties of Ganoderic acid F

Cas No. 98665-14-6 SDF Download SDF
PubChem ID 23247895 Appearance White-yellowish powder
Formula C32H42O9 M.Wt 570.7
Type of Compound Isoprenoids Storage Desiccate at -20°C
Synonyms 98665-15-7
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (6R)-6-[(5R,10S,12S,13R,14R,17R)-12-acetyloxy-4,4,10,13,14-pentamethyl-3,7,11,15-tetraoxo-2,5,6,12,16,17-hexahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxoheptanoic acid
SMILES CC(CC(=O)CC(C)C(=O)O)C1CC(=O)C2(C1(C(C(=O)C3=C2C(=O)CC4C3(CCC(=O)C4(C)C)C)OC(=O)C)C)C
Standard InChIKey BWCNWXLKMWWVBT-AIMUVTGPSA-N
Standard InChI InChI=1S/C32H42O9/c1-15(11-18(34)12-16(2)28(39)40)19-13-23(37)32(8)24-20(35)14-21-29(4,5)22(36)9-10-30(21,6)25(24)26(38)27(31(19,32)7)41-17(3)33/h15-16,19,21,27H,9-14H2,1-8H3,(H,39,40)/t15-,16?,19-,21+,27-,30+,31+,32+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Ganoderic acid F

The fruiting bodys of Ganoderma lucidum

Biological Activity of Ganoderic acid F

DescriptionGanoderic acid F has anti-hepatitis B, anti-inflammatory, and anti-tumor-promoting activities.
TargetsHBV | Immunology & Inflammation related
In vivo

Pharmacokinetics of ganoderic acids a and f after oral administration of ling zhi preparation in healthy male volunteers.[Pubmed: 22577465]

Evid Based Complement Alternat Med. 2012;2012:780892.

The objectives of this paper were to evaluate the pharmacokinetics of ganoderic acid A and Ganoderic acid F after a single oral dose of the water extract of MG2-strain Ling Zhi (MG2FB-WE) and to assess the influence of food on the pharmacokinetics in 12 healthy male volunteers.
METHODS AND RESULTS:
This study was a single-dose, open-label, randomized, two-phase crossover study with at least 2 wk washout period. Each subject was randomly assigned to receive a single oral dose of 3,000 mg of MG2FB-WE in granular formulation dissolved in 200 mL of warm water, either under a fasting condition, or immediately after a standard breakfast (fed condition). Blood samples were collected immediately before and at specific time points until 8 h after MG2FB-WE administration. Plasma ganoderic acid A and Ganoderic acid F concentrations were determined by using liquid chromatography-mass spectrometry (LC-MS) technique.
CONCLUSIONS:
In conclusion, the pharmacokinetic profile of both ganoderic acids under a fasting condition was characterized by rapid absorption from the gastrointestinal tract (T(max) at approximately 30 min) and a short elimination half-life (<40 min). Food significantly decreased C(max) and delayed T(max), but did not affect the extent of ganoderic acid A absorption. However, concomitant food intake markedly impeded both rate and extent of Ganoderic acid F absorption.

Ganoderic acid F Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Ganoderic acid F Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Ganoderic acid F

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7522 mL 8.7612 mL 17.5223 mL 35.0447 mL 43.8059 mL
5 mM 0.3504 mL 1.7522 mL 3.5045 mL 7.0089 mL 8.7612 mL
10 mM 0.1752 mL 0.8761 mL 1.7522 mL 3.5045 mL 4.3806 mL
50 mM 0.035 mL 0.1752 mL 0.3504 mL 0.7009 mL 0.8761 mL
100 mM 0.0175 mL 0.0876 mL 0.1752 mL 0.3504 mL 0.4381 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Ganoderic acid F

Pharmacokinetics of ganoderic acids a and f after oral administration of ling zhi preparation in healthy male volunteers.[Pubmed:22577465]

Evid Based Complement Alternat Med. 2012;2012:780892.

The objectives of this paper were to evaluate the pharmacokinetics of ganoderic acids A and F after a single oral dose of the water extract of MG2-strain Ling Zhi (MG2FB-WE) and to assess the influence of food on the pharmacokinetics in 12 healthy male volunteers. This study was a single-dose, open-label, randomized, two-phase crossover study with at least 2 wk washout period. Each subject was randomly assigned to receive a single oral dose of 3,000 mg of MG2FB-WE in granular formulation dissolved in 200 mL of warm water, either under a fasting condition, or immediately after a standard breakfast (fed condition). Blood samples were collected immediately before and at specific time points until 8 h after MG2FB-WE administration. Plasma ganoderic acids A and F concentrations were determined by using liquid chromatography-mass spectrometry (LC-MS) technique. In conclusion, the pharmacokinetic profile of both ganoderic acids under a fasting condition was characterized by rapid absorption from the gastrointestinal tract (T(max) at approximately 30 min) and a short elimination half-life (<40 min). Food significantly decreased C(max) and delayed T(max), but did not affect the extent of ganoderic acid A absorption. However, concomitant food intake markedly impeded both rate and extent of Ganoderic acid F absorption.

Description

Ganoderic acid F is a ganoderic acid. Ganoderic acid F exhibits antitumor and antimetastatic activities through inhibition of angiogenesis and alteration of proteins involving cell proliferation and/or cell death, carcinogenesis, oxidative stress, calcium signaling, and endoplasmic reticulum stress.

Keywords:

Ganoderic acid F,98665-14-6,98665-15-7,Natural Products, buy Ganoderic acid F , Ganoderic acid F supplier , purchase Ganoderic acid F , Ganoderic acid F cost , Ganoderic acid F manufacturer , order Ganoderic acid F , high purity Ganoderic acid F

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: