Cinobufaginol

CAS# 6691-83-4

Cinobufaginol

Catalog No. BCN8593----Order now to get a substantial discount!

Product Name & Size Price Stock
Cinobufaginol: 5mg $265 In Stock
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Quality Control of Cinobufaginol

Number of papers citing our products

Chemical structure

Cinobufaginol

3D structure

Chemical Properties of Cinobufaginol

Cas No. 6691-83-4 SDF Download SDF
PubChem ID 12303266 Appearance Powder
Formula C26H34O7 M.Wt 458.55
Type of Compound Steroids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC(=O)OC1C(C2(CCC3C(C24C1O4)CCC5C3(CCC(C5)O)CO)C)C6=COC(=O)C=C6
Standard InChIKey KDRVIPFIZZDLGB-CDIOGTMDSA-N
Standard InChI InChI=1S/C26H34O7/c1-14(28)32-22-21(15-3-6-20(30)31-12-15)24(2)9-8-18-19(26(24)23(22)33-26)5-4-16-11-17(29)7-10-25(16,18)13-27/h3,6,12,16-19,21-23,27,29H,4-5,7-11,13H2,1-2H3/t16-,17+,18+,19-,21+,22-,23-,24-,25-,26-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Cinobufaginol

The glandular body of Bufo bufo gargarizans Cantor.

Protocol of Cinobufaginol

Structure Identification
Chemical Research in Chinese Universities, 2009, 25(6):801-806.

Simultaneous Determination of Bufadienolides and Qualitative Evaluation for Venenum Bufonis by High Performance Liquid Chromatography[Reference: WebLink]

A high performance liquid chromatographic method was used for the simultaneous identification and qua-litative evaluation of 12 bufadienolides(resibufogenin, cinobufagin, Cinobufaginol, arenobufagin, bufalin, bufotalin, gamabufotalin, cinobufotalin, Ψ-bufaranogin, desacetylcinobufagin, telocinobufagin and resibufogenol) in Venenum Bufonis.
METHODS AND RESULTS:
The chromatographic separation was performed on a Dikma C 18 analytical column via gradient elution with an aqueous solution of acetonitrile and 0.3% acetic acid at a flow rate of 0.8 mL/min. The method was validated to be acceptable in consideration of linearity(r 2 > 0.9992) and recovery(ranged from 98.9% to 102.0%). The limits of de-tection of the bufadienolides were from 0.48 ng for bufalin to 6.00 ng for cinobufotalin. The intra-day and inter-day precisions of the method were evaluated and were less than 3.0%. The method was successfully used to analyze 19 batches of Venenum Bufonis, and the similarity values between batches were calculated by Similarity Evaluation System for Chromatographic Fingerprint of TCM(Version 2004A, Chinese Pharmacopoeia Committee, Beijing).
CONCLUSIONS:
The results show that the contents of bufadienolides in the medicine and the similarity values based on these bufadieno-lides varied significantly from batch to batch. This proposed method could be utilized to qualify and control Venenum Bufonis to ensure its safety and efficacy in application.

Cinobufaginol Dilution Calculator

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Cinobufaginol Molarity Calculator

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Preparing Stock Solutions of Cinobufaginol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1808 mL 10.9039 mL 21.8079 mL 43.6157 mL 54.5197 mL
5 mM 0.4362 mL 2.1808 mL 4.3616 mL 8.7231 mL 10.9039 mL
10 mM 0.2181 mL 1.0904 mL 2.1808 mL 4.3616 mL 5.452 mL
50 mM 0.0436 mL 0.2181 mL 0.4362 mL 0.8723 mL 1.0904 mL
100 mM 0.0218 mL 0.109 mL 0.2181 mL 0.4362 mL 0.5452 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Cinobufaginol

Simultaneous Determination of Bufadienolides and Qualitative Evaluation for Venenum Bufonis by High Performance Liquid Chromatography

Chemical Research in Chinese Universities, 2009, 25(6):801-806.

A high performance liquid chromatographic method was used for the simultaneous identification and qua-litative evaluation of 12 bufadienolides(resibufogenin, cinobufagin, Cinobufaginol, arenobufagin, bufalin, bufotalin, gamabufotalin, cinobufotalin, Ψ-bufaranogin, desacetylcinobufagin, telocinobufagin and resibufogenol) in Venenum Bufonis. The chromatographic separation was performed on a Dikma C 18 analytical column via gradient elution with an aqueous solution of acetonitrile and 0.3% acetic acid at a flow rate of 0.8 mL/min. The method was validated to be acceptable in consideration of linearity(r 2 > 0.9992) and recovery(ranged from 98.9% to 102.0%). The limits of de-tection of the bufadienolides were from 0.48 ng for bufalin to 6.00 ng for cinobufotalin. The intra-day and inter-day precisions of the method were evaluated and were less than 3.0%. The method was successfully used to analyze 19 batches of Venenum Bufonis, and the similarity values between batches were calculated by Similarity Evaluation System for Chromatographic Fingerprint of TCM(Version 2004A, Chinese Pharmacopoeia Committee, Beijing). The results show that the contents of bufadienolides in the medicine and the similarity values based on these bufadieno-lides varied significantly from batch to batch. This proposed method could be utilized to qualify and control Venenum Bufonis to ensure its safety and efficacy in application.

Description

Cinobufaginol is a natural bufadienolide isolated from toad venom which has been widely used for centuries in China to treat different diseases, especially for cancer. Cinobufaginol potently inhibits the activity against human nasopharyngeal carcinoma cell lines with IC50s of 803 μΜ and 1.270 μΜ for CNE-1 and CNE-2Z, respectively.

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