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Coronarin D ethyl ether

CAS# 138965-89-6

Coronarin D ethyl ether

Catalog No. BCN6203----Order now to get a substantial discount!

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Coronarin D ethyl ether: 5mg $690 In Stock
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Quality Control of Coronarin D ethyl ether

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Chemical structure

Coronarin D ethyl ether

3D structure

Chemical Properties of Coronarin D ethyl ether

Cas No. 138965-89-6 SDF Download SDF
PubChem ID 91895340 Appearance Powder
Formula C22H34O3 M.Wt 346.5
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (3E)-3-[2-[(1S,4aS,8aS)-5,5,8a-trimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-5-ethoxyoxolan-2-one
SMILES CCOC1CC(=CCC2C(=C)CCC3C2(CCCC3(C)C)C)C(=O)O1
Standard InChIKey HUJJMXMBEMUVOX-SQOKDOERSA-N
Standard InChI InChI=1S/C22H34O3/c1-6-24-19-14-16(20(23)25-19)9-10-17-15(2)8-11-18-21(3,4)12-7-13-22(17,18)5/h9,17-19H,2,6-8,10-14H2,1,3-5H3/b16-9+/t17-,18-,19?,22+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Coronarin D ethyl ether

The rhizomes of Hedychium coronarium

Biological Activity of Coronarin D ethyl ether

Description1. Coronarin D inhibits NF-KB activation pathway, which leads to inhibition of inflammation, invasion, and osteoclastogenesis, as well as potentiation of apoptosis. 2. Coronarin D shows promising antifungal activity against C. albicans in vitro.

Coronarin D ethyl ether Dilution Calculator

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Coronarin D ethyl ether Molarity Calculator

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Preparing Stock Solutions of Coronarin D ethyl ether

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.886 mL 14.43 mL 28.86 mL 57.7201 mL 72.1501 mL
5 mM 0.5772 mL 2.886 mL 5.772 mL 11.544 mL 14.43 mL
10 mM 0.2886 mL 1.443 mL 2.886 mL 5.772 mL 7.215 mL
50 mM 0.0577 mL 0.2886 mL 0.5772 mL 1.1544 mL 1.443 mL
100 mM 0.0289 mL 0.1443 mL 0.2886 mL 0.5772 mL 0.7215 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Coronarin D ethyl ether

Chemical constituents of the rhizomes of Hedychium coronarium and their inhibitory effect on the pro-inflammatory cytokines production LPS-stimulated in bone marrow-derived dendritic cells.[Pubmed:22071304]

Bioorg Med Chem Lett. 2011 Dec 15;21(24):7460-5.

The rhizomes of Hedychium coronarium have been used for the treatment of inflammation, skin diseases, headache, and sharp pain due to rheumatism in traditional medicine. From this plant, three new labdane-type diterpenes 1-3, named coronarins G-I as well as seven known 4-10, coronarin D, coronarin D methyl ether, hedyforrestin C, (E)-nerolidol, beta-sitosterol, daucosterol, and stigmasterol were isolated. Their chemical structures were elucidated by mass, 1D- and 2D-nuclear magnetic resonance spectroscopy. They were evaluated for inhibitory effects on lipopolysaccharide-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells. Among of them, compounds 1, 2, and 6 were significant inhibitors of LPS-stimulated TNF-alpha, IL-6, and IL-12 p40 productions with IC(50) ranging from 0.19+/-0.11 to 10.38+/-2.34 muM. The remains of compounds showed inactivity or due to cytotoxicity. These results warrant further studies concerning the potential anti-inflammatory benefits of labdane-type diterpenes from H. coronarium.

Labdane diterpenes from the rhizomes of Hedychium coronarium.[Pubmed:18932088]

Nat Prod Res. 2008;22(14):1249-56.

A new labdane diterpenoid, (E)-labda-8(17),12-dien-15,16-olide (1) together with eight known compounds, coronarin D (2), coronarin D methyl ether (3), Coronarin D ethyl ether (4), isocoronarin D (5), coronarin B (6), labda-8(17),11,13-trien-15,16-olide (7), (E)-labda-8(17),12-diene-15,16-dial (8) and 16-hydroxylabda-8(17),11,13-trien-15,16-olide (9), are isolated from the rhizomes of Hedychium coronarium. Compounds 2-4, 5 and 9 are isolated as mixtures of C-15, C-14 and C-16 epimers, respectively. Their structures are determined on the basis of their spectroscopic data. The epimeric mixtures of 2 and 3 have not been reported before. Some of them were evaluated for their cytotoxicity.

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