Cyclo(Ile-Ala)

CAS# 90821-99-1

Cyclo(Ile-Ala)

Catalog No. BCN2429----Order now to get a substantial discount!

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Quality Control of Cyclo(Ile-Ala)

Number of papers citing our products

Chemical structure

Cyclo(Ile-Ala)

3D structure

Chemical Properties of Cyclo(Ile-Ala)

Cas No. 90821-99-1 SDF Download SDF
PubChem ID 45359405 Appearance Powder
Formula C9H16N2O2 M.Wt 184.24
Type of Compound Miscellaneous Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 3-butan-2-yl-6-methylpiperazine-2,5-dione
SMILES CCC(C)C1C(=O)NC(C(=O)N1)C
Standard InChIKey JDRIJDPCYNFZIT-UHFFFAOYSA-N
Standard InChI InChI=1S/C9H16N2O2/c1-4-5(2)7-9(13)10-6(3)8(12)11-7/h5-7H,4H2,1-3H3,(H,10,13)(H,11,12)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Cyclo(Ile-Ala)

The roots of Panax notoginseng.

Biological Activity of Cyclo(Ile-Ala)

DescriptionCyclo(Ile-Ala) is a new cell cycle inhibitor.
In vitro

Cyclic dipeptides as new cell cycle inhibitors produced by Streptomyces flavoretus 18522[Reference: WebLink]

Journal of Shenyang Pharmaceutical University, 2015 (2) :107 -10.

To find the cell cycle inhibitors from the metabolites of Streptomyces flavoretus 18522.
METHODS AND RESULTS:
Activity-guided isolation was performed on the chloroform extract of the fermentation broth and mycelia of Streptomyces flavoretus 18522 by using ts FT210 cells.Compounds were isolated through various chromatoghraphic methods and elucidated by spectroscopic means.The flow cytometry was used to evaluate the cell cycle inhibiting activity of the fractions and compounds. Six cyclic dipeptides were obtained and identified as cyclo(Ala-Leu)(1),Cyclo(Ile-Ala) (2),cyclo(Ala-Val)(3),cyclo(Phe-Leu)(4),cyclo(Ala-Pro)(5) and cyclo(Phe-Val)(6).
CONCLUSIONS:
Compounds 1-6 are reported as new cell cycle inhibitors for the first time.

Protocol of Cyclo(Ile-Ala)

Structure Identification
《Chinese Journal of Natural Medicines》 2007-01

Chemical Constituents of the Seeds of Euryale ferox[Reference: WebLink]

To investigate the chemical constituents in the seeds of Euryale ferox Salisb for obtaining a more comprehensive understanding on its effective components.
METHODS AND RESULTS:
Compounds were separated by column chromatography with silica gel, Pharmadex LH-20 and reversed-phase silica gel. Their structures were elucidated by spectral analysis and chemical evidence. Seven compounds and a mixture of two compounds were obtained. Their structures were identified as: Cyclo(Pro-Ser) (1), Cyclo(Ile-Ala) (2), Cyclo(Leu-Ala) (3), 5,7,4′-trihydroxy-flavanone (4), 5,7,3′,4′,5′-pentahydroxy-flavanone (5), isolariciresinol-9-O-β-D-glucopyranoside (6), α-tocopherol (7), β-tocopherol (8), δ-tocopherol (9).
CONCLUSIONS:
Compound 1 was firstly isolated from natural sources; compounds 2-6 have been isolated from this plant for the first time.

Cyclo(Ile-Ala) Dilution Calculator

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Cyclo(Ile-Ala) Molarity Calculator

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Preparing Stock Solutions of Cyclo(Ile-Ala)

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.4277 mL 27.1385 mL 54.277 mL 108.5541 mL 135.6926 mL
5 mM 1.0855 mL 5.4277 mL 10.8554 mL 21.7108 mL 27.1385 mL
10 mM 0.5428 mL 2.7139 mL 5.4277 mL 10.8554 mL 13.5693 mL
50 mM 0.1086 mL 0.5428 mL 1.0855 mL 2.1711 mL 2.7139 mL
100 mM 0.0543 mL 0.2714 mL 0.5428 mL 1.0855 mL 1.3569 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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