Goshonoside F5

CAS# 90851-28-8

Goshonoside F5

Catalog No. BCN6442----Order now to get a substantial discount!

Product Name & Size Price Stock
Goshonoside F5: 5mg $903 In Stock
Goshonoside F5: 10mg Please Inquire In Stock
Goshonoside F5: 20mg Please Inquire Please Inquire
Goshonoside F5: 50mg Please Inquire Please Inquire
Goshonoside F5: 100mg Please Inquire Please Inquire
Goshonoside F5: 200mg Please Inquire Please Inquire
Goshonoside F5: 500mg Please Inquire Please Inquire
Goshonoside F5: 1000mg Please Inquire Please Inquire

Quality Control of Goshonoside F5

Number of papers citing our products

Chemical structure

Goshonoside F5

3D structure

Chemical Properties of Goshonoside F5

Cas No. 90851-28-8 SDF Download SDF
PubChem ID 13855771 Appearance Powder
Formula C32H54O13 M.Wt 646.77
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2R,3R,4S,5S,6R)-2-[(E)-5-[(1R,4aS,5S,6R,8aS)-6-hydroxy-5,8a-dimethyl-2-methylidene-5-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]-3-methylpent-2-enoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
SMILES CC(=CCOC1C(C(C(C(O1)CO)O)O)O)CCC2C(=C)CCC3C2(CCC(C3(C)COC4C(C(C(C(O4)CO)O)O)O)O)C
Standard InChIKey QIOMMMCQFIBVKA-PPQBIMEKSA-N
Standard InChI InChI=1S/C32H54O13/c1-16(10-12-42-29-27(40)25(38)23(36)19(13-33)44-29)5-7-18-17(2)6-8-21-31(18,3)11-9-22(35)32(21,4)15-43-30-28(41)26(39)24(37)20(14-34)45-30/h10,18-30,33-41H,2,5-9,11-15H2,1,3-4H3/b16-10+/t18-,19-,20-,21+,22-,23-,24-,25+,26+,27-,28-,29-,30-,31+,32-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Goshonoside F5

The leaves of Japanese R. chingii.

Biological Activity of Goshonoside F5

Description1. Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
TargetsNO | PGE | NOS | COX | p65 | NF-kB | IkB | JNK | TNF-α | p38MAPK | IKK

Goshonoside F5 Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Goshonoside F5 Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Goshonoside F5

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.5461 mL 7.7307 mL 15.4614 mL 30.9229 mL 38.6536 mL
5 mM 0.3092 mL 1.5461 mL 3.0923 mL 6.1846 mL 7.7307 mL
10 mM 0.1546 mL 0.7731 mL 1.5461 mL 3.0923 mL 3.8654 mL
50 mM 0.0309 mL 0.1546 mL 0.3092 mL 0.6185 mL 0.7731 mL
100 mM 0.0155 mL 0.0773 mL 0.1546 mL 0.3092 mL 0.3865 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Goshonoside F5

Suppression of nuclear factor-kappa B and mitogen-activated protein kinase signalling pathways by goshonoside-F5 extracted from Rubi Fructus.[Pubmed:25523460]

Int Immunopharmacol. 2015 Feb;24(2):182-190.

Rubi Fructus, a traditional Chinese medicine, was considered as an anti-inflammatory agent in folk medicine. In the present study, we investigated the signalling pathways involved in the anti-inflammatory effects of goshonoside-F5 (GF5), isolated from Rubi Fructus, in peritoneal macrophages and examined its therapeutic effect in a mouse endotoxic shock model. GF5 decreased NO and PGE2 production in LPS-stimulated macrophages (IC50=3.84 and 3.16muM). This effect involved the suppression of NOS-2 and COX-2 gene expression at the transcriptional level. Examination of the effects of GF5 on NF-kappaB signalling demonstrated that it inhibits the phosphorylation of IkappaB-alpha and IkappaB-beta, blocking their degradation and the nuclear translocation of the NF-kappaB p65 subunit. Moreover, inhibition of MAPK signalling was also observed, and phosphorylation of p38 and JNK was suppressed in the presence of GF5. Inflammatory cytokines, including IL-6 and TNF-alpha, were down-regulated by this compound after activation with LPS (IC50=17.04 and 4.09muM). Additionally, GF5 (30 and 90mg/kg, i.p.) significantly reduced the circulating cytokine levels (IL-6 and TNF-alpha) and increased survival in a mouse model of endotoxemia. These results show that GF5 significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo. Our results provide a strong pharmacological basis for further understanding the potential therapeutic role of GF5 in inflammatory disease and shed new light on the bioactivity of ent-labdane diterpene glucoside.

Keywords:

Goshonoside F5,90851-28-8,Natural Products, buy Goshonoside F5 , Goshonoside F5 supplier , purchase Goshonoside F5 , Goshonoside F5 cost , Goshonoside F5 manufacturer , order Goshonoside F5 , high purity Goshonoside F5

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: