Cyclo(Ile-Leu)

CAS# 91741-17-2

Cyclo(Ile-Leu)

Catalog No. BCN2434----Order now to get a substantial discount!

Product Name & Size Price Stock
Cyclo(Ile-Leu): 5mg $196 In Stock
Cyclo(Ile-Leu): 10mg Please Inquire In Stock
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Quality Control of Cyclo(Ile-Leu)

Number of papers citing our products

Chemical structure

Cyclo(Ile-Leu)

3D structure

Chemical Properties of Cyclo(Ile-Leu)

Cas No. 91741-17-2 SDF Download SDF
PubChem ID 63103176 Appearance Powder
Formula C12H22N2O2 M.Wt 226.32
Type of Compound Miscellaneous Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 3-butan-2-yl-6-(2-methylpropyl)piperazine-2,5-dione
SMILES CCC(C)C1C(=O)NC(C(=O)N1)CC(C)C
Standard InChIKey CCMDAWLYCNFDFN-UHFFFAOYSA-N
Standard InChI InChI=1S/C12H22N2O2/c1-5-8(4)10-12(16)13-9(6-7(2)3)11(15)14-10/h7-10H,5-6H2,1-4H3,(H,13,16)(H,14,15)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Cyclo(Ile-Leu)

The Penicillium oxalicum

Biological Activity of Cyclo(Ile-Leu)

DescriptionCyclo(Ile-Leu) shows cytotoxic activity in vitro.
In vitro

Cyclic dipeptide constituents from the mangrove fungus Penicillium oxalicum(No.092007)[Reference: WebLink]

《Journal of Shenyang Pharmaceutical University》 2007-08

To study the metabolites of mangrove fungus Penicillium oxalicum from the south China sea and search for new anti-tumor compounds.
METHODS AND RESULTS:
Compounds were isolated by silica gel,ODS column chromatography,Sephadex LH-20 column chromatography and reversed-phase HPLC purification.Structural elucidation was achieved by physico-chemical constants and spectroscopic analysis MTT assay was used to evaluate the bioactivities in vitro.Six cyclic dipeptides were isolated from the acetone extracts of mycelium of fungus and elucidated as cyclo-(Phe-Ile)(1),cyclo-(Phe-Val)(2),Cyclo(Ile-Leu)(3),cyclo-(Val-Val)(4),cyclo-(Pro-Val)(5),cyclo-(Pro-Gly)(6).Coumpouds 2,3 and 5 could evidently inhibit the growth of cancer cell lines HepG Ⅱ and LNCaP at the concentration of 50 μg·mL-1.
CONCLUSIONS:
All of Compounds are obtained from the marine fungus for the fist time.Compounds 2,Cyclo(Ile-Leu) and 5 show cytotoxic activity in vitro.

Cyclo(Ile-Leu) Dilution Calculator

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Cyclo(Ile-Leu) Molarity Calculator

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Preparing Stock Solutions of Cyclo(Ile-Leu)

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.4185 mL 22.0926 mL 44.1852 mL 88.3704 mL 110.4631 mL
5 mM 0.8837 mL 4.4185 mL 8.837 mL 17.6741 mL 22.0926 mL
10 mM 0.4419 mL 2.2093 mL 4.4185 mL 8.837 mL 11.0463 mL
50 mM 0.0884 mL 0.4419 mL 0.8837 mL 1.7674 mL 2.2093 mL
100 mM 0.0442 mL 0.2209 mL 0.4419 mL 0.8837 mL 1.1046 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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