DGAT1-IN-1CAS# 1449779-49-0 |
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Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 1449779-49-0 | SDF | Download SDF |
| PubChem ID | 71696573 | Appearance | Powder |
| Formula | C30H28F3N3O4 | M.Wt | 551.56 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : 20 mg/mL (36.26 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble) | ||
| Chemical Name | 2-[4-[4-[2-[[4-(trifluoromethoxy)phenyl]methylcarbamoyl]imidazo[1,2-a]pyridin-6-yl]phenyl]cyclohexyl]acetic acid | ||
| SMILES | C1CC(CCC1CC(=O)O)C2=CC=C(C=C2)C3=CN4C=C(N=C4C=C3)C(=O)NCC5=CC=C(C=C5)OC(F)(F)F | ||
| Standard InChIKey | KFGSQOIWOCDWAS-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C30H28F3N3O4/c31-30(32,33)40-25-12-3-20(4-13-25)16-34-29(39)26-18-36-17-24(11-14-27(36)35-26)23-9-7-22(8-10-23)21-5-1-19(2-6-21)15-28(37)38/h3-4,7-14,17-19,21H,1-2,5-6,15-16H2,(H,34,39)(H,37,38) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
DGAT1-IN-1 Dilution Calculator
DGAT1-IN-1 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.813 mL | 9.0652 mL | 18.1304 mL | 36.2608 mL | 45.326 mL |
| 5 mM | 0.3626 mL | 1.813 mL | 3.6261 mL | 7.2522 mL | 9.0652 mL |
| 10 mM | 0.1813 mL | 0.9065 mL | 1.813 mL | 3.6261 mL | 4.5326 mL |
| 50 mM | 0.0363 mL | 0.1813 mL | 0.3626 mL | 0.7252 mL | 0.9065 mL |
| 100 mM | 0.0181 mL | 0.0907 mL | 0.1813 mL | 0.3626 mL | 0.4533 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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DGAT1-IN-1 is a potent DGAT1 inhibitor with IC50 of < 10 nM(cell lysate from Hep3B cells overexpressing human DGAT1). IC50 value: < 10 nM Target: DGAT1 inhibitor Imidazopyridine and imidazothiazole compounds as inhibitors of diacylglycerol o-acyltransferase type 1 enzyme and their preparation By Kim, Dooseop; Bok, Juhan; Shin, Sunmi From PCT Int. Appl. (2013), WO 2013119040 A1 20130815.
References:
[1]. Compounds as inhibitors of diacylglycerol o-acyltransferase type 1 enzyme , Patent: WO 2013119040 A1
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DGAT1-IN-1 is a potent DGAT1 inhibitor with IC50 of < 10 nM(cell lysate from Hep3B cells overexpressing human DGAT1).
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