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Chlojaponilactone B

CAS# 1449382-91-5

Chlojaponilactone B

Catalog No. BCN7400----Order now to get a substantial discount!

Product Name & Size Price Stock
Chlojaponilactone B: 5mg $886 In Stock
Chlojaponilactone B: 10mg Please Inquire In Stock
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Quality Control of Chlojaponilactone B

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Chemical structure

Chlojaponilactone B

3D structure

Chemical Properties of Chlojaponilactone B

Cas No. 1449382-91-5 SDF Download SDF
PubChem ID 72715021 Appearance Powder
Formula C17H18O4 M.Wt 286.32
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1=C2C(C3C(=C)C4CC4C3(C=C2OC1=O)C)OC(=O)C
Standard InChIKey DJENQWQXZQCLHL-PVBKFEAWSA-N
Standard InChI InChI=1S/C17H18O4/c1-7-10-5-11(10)17(4)6-12-13(8(2)16(19)21-12)15(14(7)17)20-9(3)18/h6,10-11,14-15H,1,5H2,2-4H3/t10-,11-,14-,15+,17+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Chlojaponilactone B

The whole plants of Chloranthus japonicus.

Biological Activity of Chlojaponilactone B

Description1. Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages.
TargetsNO | NOS | TNF-α | IL Receptor | p65 | NF-kB | IkB | IKK

Chlojaponilactone B Dilution Calculator

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Chlojaponilactone B Molarity Calculator

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Preparing Stock Solutions of Chlojaponilactone B

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.4926 mL 17.463 mL 34.926 mL 69.8519 mL 87.3149 mL
5 mM 0.6985 mL 3.4926 mL 6.9852 mL 13.9704 mL 17.463 mL
10 mM 0.3493 mL 1.7463 mL 3.4926 mL 6.9852 mL 8.7315 mL
50 mM 0.0699 mL 0.3493 mL 0.6985 mL 1.397 mL 1.7463 mL
100 mM 0.0349 mL 0.1746 mL 0.3493 mL 0.6985 mL 0.8731 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Chlojaponilactone B

Chlojaponilactone B from Chloranthus japonicus: Suppression of Inflammatory Responses via Inhibition of the NF-kappaB Signaling Pathway.[Pubmed:27588583]

J Nat Prod. 2016 Sep 23;79(9):2257-63.

Bioassay-guided fractionation of an ethanolic extract of Chloranthus japonicus led to the isolation of the known lindenane-type sesquiterpenoid Chlojaponilactone B (1). This compound exhibited pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. Further anti-inflammatory assays showed that 1 suppressed the levels of some key inflammation mediators, such as iNOS, TNF-alpha, and IL-6, in a dose-dependent manner, and reduced the ear thickness and neutrophil infiltration in 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated mice. A mechanistic study revealed that compound 1 exerted its anti-inflammatory effects via the suppression of the NF-kappaB signaling pathway, which inhibited NF-kappaB-dependent transcriptional activity, IkappaBalpha phosphorylation, and p65 nuclear translocation. In contrast, Chlojaponilactone B (1) was found to exert little influence on the MAPK signaling pathway.

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