DaphneticinCAS# 83327-22-4 |
Quality Control & MSDS
3D structure
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| Cas No. | 83327-22-4 | SDF | Download SDF |
| PubChem ID | 158341.0 | Appearance | Powder |
| Formula | C20H18O8 | M.Wt | 386.36 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | 9H-pyrano[2,3-f]-1,4-benzodioxin-9-one, 2,3-dihydro-2-(4-hydroxy-3,5-dimethoxyphenyl)-3-(hydroxymethyl)-, (2R,3R)- | ||
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2R,3R)-3-(4-hydroxy-3,5-dimethoxyphenyl)-2-(hydroxymethyl)-2,3-dihydropyrano[3,2-h][1,4]benzodioxin-9-one | ||
| SMILES | COC1=CC(=CC(=C1O)OC)C2C(OC3=C(O2)C=CC4=C3OC(=O)C=C4)CO | ||
| Standard InChIKey | QLFQDIADUIVNRF-CRAIPNDOSA-N | ||
| Standard InChI | InChI=1S/C20H18O8/c1-24-13-7-11(8-14(25-2)17(13)23)18-15(9-21)27-20-12(26-18)5-3-10-4-6-16(22)28-19(10)20/h3-8,15,18,21,23H,9H2,1-2H3/t15-,18-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Daphneticin Dilution Calculator
Daphneticin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.5883 mL | 12.9413 mL | 25.8826 mL | 51.7652 mL | 64.7065 mL |
| 5 mM | 0.5177 mL | 2.5883 mL | 5.1765 mL | 10.353 mL | 12.9413 mL |
| 10 mM | 0.2588 mL | 1.2941 mL | 2.5883 mL | 5.1765 mL | 6.4706 mL |
| 50 mM | 0.0518 mL | 0.2588 mL | 0.5177 mL | 1.0353 mL | 1.2941 mL |
| 100 mM | 0.0259 mL | 0.1294 mL | 0.2588 mL | 0.5177 mL | 0.6471 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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[Simultaneous determination of daphnetin, daphnoretin, daphneticin in rat plasma by LC-MS/MS and its application in pharmacokinetic study].[Pubmed:29090558]
Zhongguo Zhong Yao Za Zhi. 2017 May;42(10):1964-1970.
To establish HPLC-MS/MS method for simultaneous determination of daphnetin, daphnoretin, and Daphneticin in rat plasma after oral and intravenous administration of Daphne giraldii extract, and then use them in the calculation of pharmacokinetic parameters. Six sprague-dawley rats received intragastric administration of D. giraldii extract (daphnetin, daphnoretin and Daphneticin were 88.40, 3.24 and 4.28 mg*kg(-)(1), respectively). Their drug plasma concentration was determined by LC-MS/MS with schisandrin as an internal standard to draw plasma concentration-time curve. The pharmacokinetic parameters were calculated by Kinetica 4.4. The results showed that the linear range was 5-1 000 mug*L(-)(1) for daphnetin, daphnoretin and Daphneticin, and the method ological test showed conformance to the requirements.The intraday and inter-day variable coefficients (RSD) were both less than 15.0%, indicating that both of legitimate precise and accuracy were consistent with the analysis requirements of biological samples. For daphnetin, the pharmacokinetic parameters Tmax, Cmax, AUC0-t, T1/2 and MRT were 4 h, 858.96 mug*L(-)(1), 10 566.4 mug*L(-)(1)*h, 5.19 h and 9.43 h, respectively. For daphnoretin, the pharmacokinetic parameters Tmax, Cmax, AUC0-t, T1/2 and MRT were 2.92 h, 178.00 mug*L(-)(1), 905.89 mug*L(-)(1)*h, 3.50 h and 6.95 h, respectively. For Daphneticin, the pharmacokinetic parameters Tmax, Cmax, AUC0-t, T1/2 and MRT were 2 h, 36.67 mug*L(-)(1), 355.11 mug*L(-)(1)*h, 4.95 h and 8.27 h, respectively. The LC-MS/MS analysis method established in this study was proved to be so accurate and sensitive that it can be applied to the pharmacokinetic study of daphnetin, daphnoretin and Daphneticin.
[Chemical constituents from Daphne acutiloba].[Pubmed:23596879]
Zhongguo Zhong Yao Za Zhi. 2013 Jan;38(1):64-9.
OBJECTIVE: To study the chemical constituents from Daphne acutiloba. METHOD: The constituents were separated by column chromatography, and their structures were elucidated by spectroscopic data analyses. RESULT: Fifteen compounds were isolated from the EtOAc extract and identified as wikstroelide M (1), vesiculosin (2), prostratin (3), 7-hydroxy-coumarin (4), 7,8-di-hydroxy-coumarin (5), isodaphnoside (6), daphnorine (7), rutamontine (8), daphnolin (9), Daphneticin (10), (+)-pinoresinol-beta-D-glucoside (11), oleodapnone (12), oleodaphnal (13), ergosterol peroxide (14) and cholest-5-en-3beta-ol (15). CONCLUSION: All the compounds except for 4, 5 and 14 were obtained from the stems of this plant for the first time.
[Chemical constituents from rhizome of Daphne papyracea var. crassiuscula].[Pubmed:23373217]
Zhongguo Zhong Yao Za Zhi. 2012 Nov;37(22):3434-7.
OBJECTIVE: To study chemical constituents from rhizome of Daphne papyracea var. crassiuscula. METHOD: Ethyl acetate fraction of 75% ethanol extracts from rhizome of D. papyracea var. crassiuscula, and its strucutre was identified by spectral method. RESULT: Nine compounds were separated and identified as Daphneticin (1), daphnetin (2), hydrangetin (3), daphnoretin (4), 1-4'-hydroxyphenyl-5-phenyl-2 (E)-en-1-pentanone (5), daphneolon (6), 3beta-O-acetyl-olean-12-en (7), and (+)-usnic acid (8). CONCLUSION: Compounds 1-8 were separated from D. papyracea var. crassiuscula for the first time. Compound 8 was separated from the genus for first time.
