DeacetyltaxolCAS# 78432-77-6 |
- 7-Epi 10-Desacetyl Paclitaxel
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Quality Control & MSDS
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| Cas No. | 78432-77-6 | SDF | Download SDF |
| PubChem ID | 155831 | Appearance | Powder |
| Formula | C45H49NO13 | M.Wt | 811.87 |
| Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)O | ||
| Standard InChIKey | TYLVGQKNNUHXIP-MHHARFCSSA-N | ||
| Standard InChI | InChI=1S/C45H49NO13/c1-24-29(57-41(54)35(50)33(26-15-9-6-10-16-26)46-39(52)27-17-11-7-12-18-27)22-45(55)38(58-40(53)28-19-13-8-14-20-28)36-43(5,37(51)34(49)32(24)42(45,3)4)30(48)21-31-44(36,23-56-31)59-25(2)47/h6-20,29-31,33-36,38,48-50,55H,21-23H2,1-5H3,(H,46,52)/t29-,30-,31+,33-,34+,35+,36-,38-,43+,44-,45+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 10-Deacetyltaxol and cephalomannine have cytotoxicity in human glial and neuroblastoma cell-lines, the tumors of the central and peripheral nervous system are sensitive to 10-deacetyltaxol and cephalomannine and these drugs are less toxic than taxol but remain within a therapeutic range. |
| In vitro | Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines.[Pubmed: 21573554]Int. J.Oncol., 1993, 2(2):297-9.
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Deacetyltaxol Dilution Calculator
Deacetyltaxol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.2317 mL | 6.1586 mL | 12.3172 mL | 24.6345 mL | 30.7931 mL |
| 5 mM | 0.2463 mL | 1.2317 mL | 2.4634 mL | 4.9269 mL | 6.1586 mL |
| 10 mM | 0.1232 mL | 0.6159 mL | 1.2317 mL | 2.4634 mL | 3.0793 mL |
| 50 mM | 0.0246 mL | 0.1232 mL | 0.2463 mL | 0.4927 mL | 0.6159 mL |
| 100 mM | 0.0123 mL | 0.0616 mL | 0.1232 mL | 0.2463 mL | 0.3079 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines.[Pubmed:21573554]
Int J Oncol. 1993 Feb;2(2):297-9.
The cytotoxic effects of taxol, 10-Deacetyltaxol, and cephalomannine at concentrations of 0.1 mug/ml to 10.0 mug/ml for one and 24 hours exposure were determined in two human glioblastoma multiforme and two neuroblastoma cell lines using the MTT method. The neuroblastoma cell lines were established from previously treated patients, while the glioblastomas were from untreated patients. There was a proportionate concentration-toxicity relationship for all four cell lines. The neuroblastoma SK-N-FI was consistently the most resistant to all three drugs. The order of potency after a one hour exposure was taxol, 10-Deacetyltaxol and cephalomannine. Cephalomannine contained 1.5% taxol impurity and 10-Deacetyltaxol, 4.5% taxol hence the contribution of taxol to these substances' toxic effects was minimal. We conclude that tumors of the central and peripheral nervous system are sensitive to 10-Deacetyltaxol and cephalomannine and these drugs are less toxic than taxol but remain within a therapeutic range.
