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Desmethylrocaglamide

CAS# 146408-78-8

Desmethylrocaglamide

Catalog No. BCN7735----Order now to get a substantial discount!

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Desmethylrocaglamide: 5mg $1098 In Stock
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Quality Control of Desmethylrocaglamide

Number of papers citing our products

Chemical structure

Desmethylrocaglamide

3D structure

Chemical Properties of Desmethylrocaglamide

Cas No. 146408-78-8 SDF Download SDF
PubChem ID 9826915 Appearance Powder
Formula C28H29NO7 M.Wt 491.53
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N-methyl-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide
SMILES CNC(=O)C1C(C2(C(C1O)(C3=C(C=C(C=C3O2)OC)OC)O)C4=CC=C(C=C4)OC)C5=CC=CC=C5
Standard InChIKey UUOCVXYUMKAOKK-GWNOIRNCSA-N
Standard InChI InChI=1S/C28H29NO7/c1-29-26(31)22-23(16-8-6-5-7-9-16)28(17-10-12-18(33-2)13-11-17)27(32,25(22)30)24-20(35-4)14-19(34-3)15-21(24)36-28/h5-15,22-23,25,30,32H,1-4H3,(H,29,31)/t22-,23-,25-,27+,28+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Desmethylrocaglamide

The twigs of Aglaia odorata.

Biological Activity of Desmethylrocaglamide

Description1. Desmethylrocaglamide has insecticidal activity. 2. Desmethylrocaglamide is a novel inducer of cellular differentiation using HL-60 promyelocytic cells, it may be a drug for the prevention and therapy of cancer.

Desmethylrocaglamide Dilution Calculator

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Desmethylrocaglamide Molarity Calculator

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Preparing Stock Solutions of Desmethylrocaglamide

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0345 mL 10.1723 mL 20.3446 mL 40.6893 mL 50.8616 mL
5 mM 0.4069 mL 2.0345 mL 4.0689 mL 8.1379 mL 10.1723 mL
10 mM 0.2034 mL 1.0172 mL 2.0345 mL 4.0689 mL 5.0862 mL
50 mM 0.0407 mL 0.2034 mL 0.4069 mL 0.8138 mL 1.0172 mL
100 mM 0.0203 mL 0.1017 mL 0.2034 mL 0.4069 mL 0.5086 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Desmethylrocaglamide

Discovery of novel inducers of cellular differentiation using HL-60 promyelocytic cells.[Pubmed:11497257]

Anticancer Res. 2001 May-Jun;21(3B):1763-70.

Non-physiological inducers of terminal differentiation have been used as novel therapies for the prevention and therapy of cancer. We have used cultured HL-60 promyelocytic cells to monitor differentiation, proliferation and cell death events as induced by a large set of extracts derived from plants. Screening of more than 1400 extracts led to the discovery of 34 with potent activity (ED50 <8 mg/ml). Bioassay-guided fractionation led to the isolation of zapotin and 2',5,6-trimethoxyflavone as active principles from Casimiroa edulis, dibenzyltrisulfide and 2-[(phenylmethyl)dithio]ethanol as active principles from Petiveria alliacea, and Desmethylrocaglamide from Aglaia ponapensis. Zapotin demonstrated the most favorable biological profile in that induction of differentiation correlated with proliferation arrest, and a lack of cytotoxicity. We conclude that the HL-60 cell model is a useful system for the discovery of novel pharmacophores with potential to suppress the process of carcinogenesis, and that flavonoids may be especially useful in this capacity.

Insecticidal flavaglines and other compounds from Fijian Aglaia species.[Pubmed:11336261]

Phytochemistry. 2001 May;57(1):57-64.

Bioassays with lipophilic crude extracts of four Fijian Aglaia species against Spodoptera littoralis displayed strong insecticidal activity for A. basiphylla and A. gracilis, whereas A. archboldiana and A. vitiensis did not have any significant effects. The insect toxicity of A. basiphylla was caused by the well known benzofuran flavaglines rocaglamide, Desmethylrocaglamide and aglafoline. In contrast, A. gracilis contained four related pyrimidinone derivatives in the root and stem bark, including two new congeners named marikarin and 3'-hydroxymarikarin. Moreover, two new putrescine bisamides, secoodorine and secopiriferine, a new benzopyran flavagline. desacetylaglain A. and a new norsesquiterpene were isolated from the leaves together with three known bisamides and 3-hydroxy-5,7,4'-trimethoxyflavone. The structures of the new compounds were elucidated by spectroscopic methods. Comparative feeding assays within the active pyrimidinone flavaglines showed that the free hydroxy group in aromatic ring A of marikarin diminishes insecticidal activity.

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