Diarylcomosol IIICAS# 1452487-93-2 |
Quality Control & MSDS
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| Cas No. | 1452487-93-2 | SDF | Download SDF |
| PubChem ID | 72164690 | Appearance | Oil |
| Formula | C21H28O6 | M.Wt | 376.44 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (3R,5S)-1-(4-hydroxy-3,5-dimethoxyphenyl)-7-(4-hydroxyphenyl)heptane-3,5-diol | ||
| SMILES | COC1=CC(=CC(=C1O)OC)CCC(CC(CCC2=CC=C(C=C2)O)O)O | ||
| Standard InChIKey | OJGXSPXNGOVDNO-ZWKOTPCHSA-N | ||
| Standard InChI | InChI=1S/C21H28O6/c1-26-19-11-15(12-20(27-2)21(19)25)6-10-18(24)13-17(23)9-5-14-3-7-16(22)8-4-14/h3-4,7-8,11-12,17-18,22-25H,5-6,9-10,13H2,1-2H3/t17-,18+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The dried rhizomes of Curcuma comosa.
| Description | 1, Diarylcomosol III shows inhibitory effects on melanogenesis in B16 melanoma cells, it is a promising therapeutic agent for the treatment of skin disorders. |
Diarylcomosol III Dilution Calculator
Diarylcomosol III Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.6565 mL | 13.2823 mL | 26.5647 mL | 53.1293 mL | 66.4116 mL |
| 5 mM | 0.5313 mL | 2.6565 mL | 5.3129 mL | 10.6259 mL | 13.2823 mL |
| 10 mM | 0.2656 mL | 1.3282 mL | 2.6565 mL | 5.3129 mL | 6.6412 mL |
| 50 mM | 0.0531 mL | 0.2656 mL | 0.5313 mL | 1.0626 mL | 1.3282 mL |
| 100 mM | 0.0266 mL | 0.1328 mL | 0.2656 mL | 0.5313 mL | 0.6641 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Diarylheptanoids with inhibitory effects on melanogenesis from the rhizomes of Curcuma comosa in B16 melanoma cells.[Pubmed:23910596]
Bioorg Med Chem Lett. 2013 Sep 15;23(18):5178-81.
The methanolic extract from the dried rhizomes of Curcuma comosa cultivated in Thailand was found to inhibit melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells. From the methanolic extract, three new diarylheptanoids, diarylcomosols I-III, were isolated together with 12 known diarylheptanoids. Their chemical structures were elucidated on the basis of chemical and physicochemical evidence. The diarylheptanoids inhibited melanogenesis, and several structural requirements of the active constituents for the inhibition were clarified. In particular, (3R)-1,7-bis(4-hydroxyphenyl)-(6E)-6-hepten-3-ol exhibited stronger inhibitory effect [IC50=0.36 muM] without inducing cytotoxicity. The biological effect was much stronger than that of a reference compound, arbutin [IC50=174 muM]. We conclude that diarylheptanoid analogs are promising therapeutic agents for the treatment of skin disorders.
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