Diarylcomosol IIICAS# 1452487-93-2 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 1452487-93-2 | SDF | Download SDF |
| PubChem ID | 72164690 | Appearance | Oil |
| Formula | C21H28O6 | M.Wt | 376.44 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (3R,5S)-1-(4-hydroxy-3,5-dimethoxyphenyl)-7-(4-hydroxyphenyl)heptane-3,5-diol | ||
| SMILES | COC1=CC(=CC(=C1O)OC)CCC(CC(CCC2=CC=C(C=C2)O)O)O | ||
| Standard InChIKey | OJGXSPXNGOVDNO-ZWKOTPCHSA-N | ||
| Standard InChI | InChI=1S/C21H28O6/c1-26-19-11-15(12-20(27-2)21(19)25)6-10-18(24)13-17(23)9-5-14-3-7-16(22)8-4-14/h3-4,7-8,11-12,17-18,22-25H,5-6,9-10,13H2,1-2H3/t17-,18+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The dried rhizomes of Curcuma comosa.
| Description | 1, Diarylcomosol III shows inhibitory effects on melanogenesis in B16 melanoma cells, it is a promising therapeutic agent for the treatment of skin disorders. |
Diarylcomosol III Dilution Calculator
Diarylcomosol III Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.6565 mL | 13.2823 mL | 26.5647 mL | 53.1293 mL | 66.4116 mL |
| 5 mM | 0.5313 mL | 2.6565 mL | 5.3129 mL | 10.6259 mL | 13.2823 mL |
| 10 mM | 0.2656 mL | 1.3282 mL | 2.6565 mL | 5.3129 mL | 6.6412 mL |
| 50 mM | 0.0531 mL | 0.2656 mL | 0.5313 mL | 1.0626 mL | 1.3282 mL |
| 100 mM | 0.0266 mL | 0.1328 mL | 0.2656 mL | 0.5313 mL | 0.6641 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Featured Products
- Sahandol
Catalog No.:BCN6996
CAS No.:1452398-07-0
- Delgrandine
Catalog No.:BCN8122
CAS No.:145237-05-4
- Clobenpropit dihydrobromide
Catalog No.:BCC6781
CAS No.:145231-35-2
- CALP1
Catalog No.:BCC5873
CAS No.:145224-99-3
- Punctanecine
Catalog No.:BCN2018
CAS No.:145204-91-7
- Rizatriptan Benzoate
Catalog No.:BCC3852
CAS No.:145202-66-0
- Kaliotoxin
Catalog No.:BCC7710
CAS No.:145199-73-1
- Iodophenpropit dihydrobromide
Catalog No.:BCC6793
CAS No.:145196-87-8
- 3beta-Hydroxyporiferast-5-en-7-one
Catalog No.:BCN6256
CAS No.:145163-97-9
- CP 99994 dihydrochloride
Catalog No.:BCC6016
CAS No.:145148-39-6
- 6-Hydroxykaempferol 3-Rutinoside -6-glucoside
Catalog No.:BCN1561
CAS No.:145134-63-0
- 6-Hydroxykaempferol-3,6,7-triglucoside
Catalog No.:BCN1562
CAS No.:145134-62-9
New Products
- 20(R)-Protopanaxatriol
Catalog No.:BCN1079
CAS No.:1453-93-6
- A 77636 hydrochloride
Catalog No.:BCC7159
CAS No.:145307-34-2
- TC-E 5002
Catalog No.:BCC5608
CAS No.:1453071-47-0
- Bergenin pentaacetate
Catalog No.:BCN6257
CAS No.:14531-47-6
- Dihydropinosylvin
Catalog No.:BCN6258
CAS No.:14531-52-3
- Isochlorogenic acid B
Catalog No.:BCN5909
CAS No.:14534-61-3
- Sideroxylonal A
Catalog No.:BCN1645
CAS No.:145382-68-9
- GDC-0994
Catalog No.:BCC6371
CAS No.:1453848-26-4
- 1,4,7-Eudesmanetriol
Catalog No.:BCN1646
CAS No.:145400-02-8
- Homalomenol A
Catalog No.:BCN1647
CAS No.:145400-03-9
- L-692,585
Catalog No.:BCC7305
CAS No.:145455-35-2
- Heterophyllin B
Catalog No.:BCN2768
CAS No.:145459-19-4
Diarylheptanoids with inhibitory effects on melanogenesis from the rhizomes of Curcuma comosa in B16 melanoma cells.[Pubmed:23910596]
Bioorg Med Chem Lett. 2013 Sep 15;23(18):5178-81.
The methanolic extract from the dried rhizomes of Curcuma comosa cultivated in Thailand was found to inhibit melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells. From the methanolic extract, three new diarylheptanoids, diarylcomosols I-III, were isolated together with 12 known diarylheptanoids. Their chemical structures were elucidated on the basis of chemical and physicochemical evidence. The diarylheptanoids inhibited melanogenesis, and several structural requirements of the active constituents for the inhibition were clarified. In particular, (3R)-1,7-bis(4-hydroxyphenyl)-(6E)-6-hepten-3-ol exhibited stronger inhibitory effect [IC50=0.36 muM] without inducing cytotoxicity. The biological effect was much stronger than that of a reference compound, arbutin [IC50=174 muM]. We conclude that diarylheptanoid analogs are promising therapeutic agents for the treatment of skin disorders.
Diarylcomosol III,1452487-93-2,Natural Products, buy Diarylcomosol III , Diarylcomosol III supplier , purchase Diarylcomosol III , Diarylcomosol III cost , Diarylcomosol III manufacturer , order Diarylcomosol III , high purity Diarylcomosol III
