Home >> Research Area >>Natural Products>>Phenols>> Diarylcomosol III

Diarylcomosol III

CAS# 1452487-93-2

Diarylcomosol III

Catalog No. BCN7201----Order now to get a substantial discount!

Product Name & Size Price Stock
Diarylcomosol III: 5mg $886 In Stock
Diarylcomosol III: 10mg Please Inquire In Stock
Diarylcomosol III: 20mg Please Inquire Please Inquire
Diarylcomosol III: 50mg Please Inquire Please Inquire
Diarylcomosol III: 100mg Please Inquire Please Inquire
Diarylcomosol III: 200mg Please Inquire Please Inquire
Diarylcomosol III: 500mg Please Inquire Please Inquire
Diarylcomosol III: 1000mg Please Inquire Please Inquire

Quality Control of Diarylcomosol III

Number of papers citing our products

Chemical structure

Diarylcomosol III

3D structure

Chemical Properties of Diarylcomosol III

Cas No. 1452487-93-2 SDF Download SDF
PubChem ID 72164690 Appearance Oil
Formula C21H28O6 M.Wt 376.44
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (3R,5S)-1-(4-hydroxy-3,5-dimethoxyphenyl)-7-(4-hydroxyphenyl)heptane-3,5-diol
SMILES COC1=CC(=CC(=C1O)OC)CCC(CC(CCC2=CC=C(C=C2)O)O)O
Standard InChIKey OJGXSPXNGOVDNO-ZWKOTPCHSA-N
Standard InChI InChI=1S/C21H28O6/c1-26-19-11-15(12-20(27-2)21(19)25)6-10-18(24)13-17(23)9-5-14-3-7-16(22)8-4-14/h3-4,7-8,11-12,17-18,22-25H,5-6,9-10,13H2,1-2H3/t17-,18+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Diarylcomosol III

The dried rhizomes of Curcuma comosa.

Biological Activity of Diarylcomosol III

Description1, Diarylcomosol III shows inhibitory effects on melanogenesis in B16 melanoma cells, it is a promising therapeutic agent for the treatment of skin disorders.

Diarylcomosol III Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Diarylcomosol III Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Diarylcomosol III

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6565 mL 13.2823 mL 26.5647 mL 53.1293 mL 66.4116 mL
5 mM 0.5313 mL 2.6565 mL 5.3129 mL 10.6259 mL 13.2823 mL
10 mM 0.2656 mL 1.3282 mL 2.6565 mL 5.3129 mL 6.6412 mL
50 mM 0.0531 mL 0.2656 mL 0.5313 mL 1.0626 mL 1.3282 mL
100 mM 0.0266 mL 0.1328 mL 0.2656 mL 0.5313 mL 0.6641 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Diarylcomosol III

Diarylheptanoids with inhibitory effects on melanogenesis from the rhizomes of Curcuma comosa in B16 melanoma cells.[Pubmed:23910596]

Bioorg Med Chem Lett. 2013 Sep 15;23(18):5178-81.

The methanolic extract from the dried rhizomes of Curcuma comosa cultivated in Thailand was found to inhibit melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells. From the methanolic extract, three new diarylheptanoids, diarylcomosols I-III, were isolated together with 12 known diarylheptanoids. Their chemical structures were elucidated on the basis of chemical and physicochemical evidence. The diarylheptanoids inhibited melanogenesis, and several structural requirements of the active constituents for the inhibition were clarified. In particular, (3R)-1,7-bis(4-hydroxyphenyl)-(6E)-6-hepten-3-ol exhibited stronger inhibitory effect [IC50=0.36 muM] without inducing cytotoxicity. The biological effect was much stronger than that of a reference compound, arbutin [IC50=174 muM]. We conclude that diarylheptanoid analogs are promising therapeutic agents for the treatment of skin disorders.

Keywords:

Diarylcomosol III,1452487-93-2,Natural Products, buy Diarylcomosol III , Diarylcomosol III supplier , purchase Diarylcomosol III , Diarylcomosol III cost , Diarylcomosol III manufacturer , order Diarylcomosol III , high purity Diarylcomosol III

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: