SahandolCAS# 1452398-07-0 |
Quality Control & MSDS
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| Cas No. | 1452398-07-0 | SDF | Download SDF |
| PubChem ID | 124823434 | Appearance | Oil |
| Formula | C20H24O2 | M.Wt | 296.41 |
| Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC1=C2CC(OC3=C2C(=CC(=C3O)C(C)C)C=C1)C=C(C)C | ||
| Standard InChIKey | YUJYBTHGJZXOKE-HNNXBMFYSA-N | ||
| Standard InChI | InChI=1S/C20H24O2/c1-11(2)8-15-10-17-13(5)6-7-14-9-16(12(3)4)19(21)20(22-15)18(14)17/h6-9,12,15,21H,10H2,1-5H3/t15-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The roots of Salvia sahendica.
| Description | 1. Sahandol shows antiprotozoal activity against P. falciparum and T. brucei rhodesiense. |
| Targets | Antifection |
Sahandol Dilution Calculator
Sahandol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.3737 mL | 16.8685 mL | 33.7371 mL | 67.4741 mL | 84.3426 mL |
| 5 mM | 0.6747 mL | 3.3737 mL | 6.7474 mL | 13.4948 mL | 16.8685 mL |
| 10 mM | 0.3374 mL | 1.6869 mL | 3.3737 mL | 6.7474 mL | 8.4343 mL |
| 50 mM | 0.0675 mL | 0.3374 mL | 0.6747 mL | 1.3495 mL | 1.6869 mL |
| 100 mM | 0.0337 mL | 0.1687 mL | 0.3374 mL | 0.6747 mL | 0.8434 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Abietane diterpenoids from Salvia sahendica--antiprotozoal activity and determination of their absolute configurations.[Pubmed:23299758]
Planta Med. 2013 Jan;79(2):150-6.
In a screening of Iranian plants for antiprotozoal activity, an n-hexane extract of the roots of Salvia sahendica potently inhibited the growth of Plasmodium falciparum K1 strain. Subsequent HPLC-based activity profiling led to the identification of seven known and one new abietane-type diterpenoid. Structure elucidation was achieved by analysis of spectroscopic data including 1D and 2D NMR. The absolute configuration of Sahandol (7) and sahandone (8) were assigned by comparison of experimental ECD spectra with calculated ECD data, using time-dependent density functional theory and methanol as the solvent. In vitro biological activity against P. falciparum and Trypanosoma brucei rhodesiense STIB 900 strain and cytotoxicity in rat myoblast (L6) cells were determined. The IC50 values of the compounds ranged from 0.8 microM to over 8.8 microM against P. falciparum, and from 1.8 microM to over 32.3 microM against T. brucei rhodesiense. The cytotoxic IC50 values ranged from 0.5-15.5 microM. Selectivity indices for P. falciparum were 0.1 to 18.2, and 0.1 to 1.2 for T. brucei rhodesiense.
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