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Ditryptophenaline

CAS# 64947-43-9

Ditryptophenaline

2D Structure

Catalog No. BCN7408----Order now to get a substantial discount!

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Ditryptophenaline: 5mg $1415 In Stock
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Quality Control of Ditryptophenaline

3D structure

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Ditryptophenaline

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Chemical Properties of Ditryptophenaline

Cas No. 64947-43-9 SDF Download SDF
PubChem ID 11445389 Appearance Powder
Formula C42H40N6O4 M.Wt 692.80
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CN1C(C(=O)N2C(C1=O)CC3(C2NC4=CC=CC=C43)C56CC7C(=O)N(C(C(=O)N7C5NC8=CC=CC=C68)CC9=CC=CC=C9)C)CC1=CC=CC=C1
Standard InChIKey IQIGYVQQRKFGLN-HSYVCWSSSA-N
Standard InChI InChI=1S/C42H40N6O4/c1-45-31(21-25-13-5-3-6-14-25)37(51)47-33(35(45)49)23-41(27-17-9-11-19-29(27)43-39(41)47)42-24-34-36(50)46(2)32(22-26-15-7-4-8-16-26)38(52)48(34)40(42)44-30-20-12-10-18-28(30)42/h3-20,31-34,39-40,43-44H,21-24H2,1-2H3/t31-,32-,33-,34-,39-,40-,41+,42+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Ditryptophenaline

The metabolites of Aspergillus flavus.

Biological Activity of Ditryptophenaline

Description1. Ditryptophenaline inhibits substance P receptor for potential analgesic and anti-inflammatory activity.
TargetsImmunology & Inflammation related | P450 (e.g. CYP17)

Ditryptophenaline Dilution Calculator

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Ditryptophenaline Molarity Calculator

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Preparing Stock Solutions of Ditryptophenaline

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.4434 mL 7.2171 mL 14.4342 mL 28.8684 mL 36.0855 mL
5 mM 0.2887 mL 1.4434 mL 2.8868 mL 5.7737 mL 7.2171 mL
10 mM 0.1443 mL 0.7217 mL 1.4434 mL 2.8868 mL 3.6085 mL
50 mM 0.0289 mL 0.1443 mL 0.2887 mL 0.5774 mL 0.7217 mL
100 mM 0.0144 mL 0.0722 mL 0.1443 mL 0.2887 mL 0.3609 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Ditryptophenaline

A new diketopiperazine alkaloid from Aspergillus oryzae.[Pubmed:24116376]

Nat Prod Res. 2014;28(2):86-94.

Investigation of bioactive secondary metabolites from terrestrial Aspergillus oryzae sp. MMAO1 using M2 medium afforded a new diketopiperazine alkaloid, 7,9-dihydroxy-3-(1H-indol-3-ylmethyl)-8-methoxy-2,3,11,11a-tetrahydro-6H-pyrazino [1,2-b]isoquinoline-1,4-dione (1a), containing the unusual amino acid L-6,8-dihydroxy-7-methoxyphenylalanine. This was co-isolated with Ditryptophenaline (2), cyclo-(Tryp,Tyr) (4), cyclo-(Pro,Val), alpha-cyclopiazonic acid (3), kojic acid and uridine. Re-cultivation of the fungal strain on Dox medium led to the production of bisdethio(bismethylthio)gliotoxin (5), pseurotin A (6) along with linoleic acid, alpha-cyclopiazonic acid (3) and kojic acid. The chemical structure of the new diketopiperazine alkaloid including the relative configuration was determined by 1D and 2D NMR spectroscopy and HR-ESI-MS spectrometry, and by comparison with the related literature. The new alkaloid (1a) showed no antimicrobial activity or cytotoxicity against brine shrimps.

Cytochrome P450 as dimerization catalyst in diketopiperazine alkaloid biosynthesis.[Pubmed:24677498]

Chembiochem. 2014 Mar 21;15(5):656-9.

As dimeric natural products frequently exhibit useful biological activities, identifying and understanding their mechanisms of dimerization is of great interest. One such compound is (-)-Ditryptophenaline, isolated from Aspergillus flavus, which inhibits substance P receptor for potential analgesic and anti-inflammatory activity. Through targeted gene knockout in A. flavus and heterologous yeast gene expression, we determined for the first time the gene cluster and pathway for the biosynthesis of a dimeric diketopiperazine alkaloid. We also determined that a single cytochrome P450, DtpC, is responsible not only for pyrroloindole ring formation but also for concurrent dimerization of N-methylphenylalanyltryptophanyl diketopiperazine monomers into a homodimeric product. Furthermore, DtpC exhibits relaxed substrate specificity, allowing the formation of two new dimeric compounds from a non-native monomeric precursor, brevianamide F. A radical-mediated mechanism of dimerization is proposed.

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