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Schisantherin E

CAS# 64917-83-5

Schisantherin E

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Schisantherin E: 5mg $150 In Stock
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Quality Control of Schisantherin E

Number of papers citing our products

Chemical structure

Schisantherin E

3D structure

Chemical Properties of Schisantherin E

Cas No. 64917-83-5 SDF Download SDF
PubChem ID 13844274 Appearance Powder
Formula C30H34O9 M.Wt 538.6
Type of Compound Lignans Storage Desiccate at -20°C
Synonyms Schizantherin-E
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1CC2=CC(=C(C(=C2C3=C(C(=C(C=C3C(C1(C)O)OC(=O)C4=CC=CC=C4)OC)OC)OC)OC)OC)O
Standard InChIKey ZNXDFTKQSCEJGE-DSASHONVSA-N
Standard InChI InChI=1S/C30H34O9/c1-16-13-18-14-20(31)24(35-4)26(37-6)22(18)23-19(15-21(34-3)25(36-5)27(23)38-7)28(30(16,2)33)39-29(32)17-11-9-8-10-12-17/h8-12,14-16,28,31,33H,13H2,1-7H3/t16-,28-,30-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Schisantherin E

The fruits of Schisandra chinensis

Biological Activity of Schisantherin E

DescriptionSchisantherin E is a natural compound isolated from the active fraction of the fruits of Schisandra sphenanthera Rehd. et Wils.

Protocol of Schisantherin E

Structure Identification
Sci Sin. 1978 Jul-Aug;21(4):483-502.

Studies on the active principles of Schisandra sphenanthera Rehd. et Wils. The structures of schisantherin A, B, C, D, E, and the related compounds.[Pubmed: 233922]

Deoxyschisandrin (VIII) and five new lignans, named schisantherin A, schisantherin B, schisantherin C, schisantherin D, and Schisantherin E, were isolated from the active fraction of the fruits of Schisandra sphenanthera Rehd. et Wils.
METHODS AND RESULTS:
Their configurations and conformations were established by exhaustive spectral analysis as well as chemical degradations as shown in Ia, Ib; IIa, IIb; IIIa, IIIb; IVa, IVb, and Va, Vb respectively, and their absolute configurations at biphenyl, at C6, C7, and C8 were all assigned to be S form. The position of the methylenedioxyl group in the structures of gamma-schisandrin and Wuweizisu C (as described in the literature), isolated from Schisandra chinensis, must be corrected as shown in VI and VII respectively.
CONCLUSIONS:
In pharmacologica studies and preliminary clinical trials, schisantherin A, B, C, and D showed good effect in lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hepatitis. Schisantherin E and deoxyschisandrin were not effective.

Schisantherin E Dilution Calculator

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Schisantherin E Molarity Calculator

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Preparing Stock Solutions of Schisantherin E

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.8567 mL 9.2833 mL 18.5667 mL 37.1333 mL 46.4166 mL
5 mM 0.3713 mL 1.8567 mL 3.7133 mL 7.4267 mL 9.2833 mL
10 mM 0.1857 mL 0.9283 mL 1.8567 mL 3.7133 mL 4.6417 mL
50 mM 0.0371 mL 0.1857 mL 0.3713 mL 0.7427 mL 0.9283 mL
100 mM 0.0186 mL 0.0928 mL 0.1857 mL 0.3713 mL 0.4642 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Schisantherin E

Schisantherin E is a natural compound isolated from the active fraction of the fruits of Schisandra sphenanthera Rehd. et Wils.

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References on Schisantherin E

Studies on the active principles of Schisandra sphenanthera Rehd. et Wils. The structures of schisantherin A, B, C, D, E, and the related compounds.[Pubmed:233922]

Sci Sin. 1978 Jul-Aug;21(4):483-502.

Deoxyschisandrin (VIII) and five new lignans, named schisantherin A, B, C, D, and E, were isolated from the active fraction of the fruits of Schisandra sphenanthera Rehd. et Wils. Their configurations and conformations were established by exhaustive spectral analysis as well as chemical degradations as shown in Ia, Ib; IIa, IIb; IIIa, IIIb; IVa, IVb, and Va, Vb respectively, and their absolute configurations at biphenyl, at C6, C7, and C8 were all assigned to be S form. The position of the methylenedioxyl group in the structures of gamma-schisandrin and Wuweizisu C (as described in the literature), isolated from Schisandra chinensis, must be corrected as shown in VI and VII respectively. In pharmacologica studies and preliminary clinical trials, schisantherin A, B, C, and D showed good effect in lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hepatitis. Schisantherin E and deoxyschisandrin were not effective.

Description

Schisantherin E is a natural compound isolated from the active fraction of the fruits of Schisandra sphenanthera Rehd. et Wils.

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