FPH2 (BRD-9424)inducer of proliferation of primary human hepatocytes CAS# 957485-64-2 |
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Quality Control & MSDS
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| Cas No. | 957485-64-2 | SDF | Download SDF |
| PubChem ID | 2208391 | Appearance | Powder |
| Formula | C14H16ClN5O2S | M.Wt | 353.83 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | BRD-9424 | ||
| Solubility | DMSO : ≥ 125 mg/mL (353.28 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | 4-[(5-chloro-2-methoxyphenyl)carbamothioylamino]-1-ethylpyrazole-3-carboxamide | ||
| SMILES | CCN1C=C(C(=N1)C(=O)N)NC(=S)NC2=C(C=CC(=C2)Cl)OC | ||
| Standard InChIKey | PCHRYHSDDPPZBV-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C14H16ClN5O2S/c1-3-20-7-10(12(19-20)13(16)21)18-14(23)17-9-6-8(15)4-5-11(9)22-2/h4-7H,3H2,1-2H3,(H2,16,21)(H2,17,18,23) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | FPH2 (BRD-9424) is a small molecule promoter of differentiation of iPS-derived hepatocytes. |
FPH2 (BRD-9424) Dilution Calculator
FPH2 (BRD-9424) Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.8262 mL | 14.1311 mL | 28.2622 mL | 56.5243 mL | 70.6554 mL |
| 5 mM | 0.5652 mL | 2.8262 mL | 5.6524 mL | 11.3049 mL | 14.1311 mL |
| 10 mM | 0.2826 mL | 1.4131 mL | 2.8262 mL | 5.6524 mL | 7.0655 mL |
| 50 mM | 0.0565 mL | 0.2826 mL | 0.5652 mL | 1.1305 mL | 1.4131 mL |
| 100 mM | 0.0283 mL | 0.1413 mL | 0.2826 mL | 0.5652 mL | 0.7066 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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FPH2 (BRD-9424) is an inducer of functional proliferation of primary human hepatocytes [1].
Human hepatocytes are capable of extensive expansion. With partial hepatectomy, the residual hepatocytes are able to proliferate and replace lost liver mass [1].
FPH2 (BRD-9424) is an inducer of proliferation of primary human hepatocytes. In vitro, FPH2 induced functional proliferation of hepatocytes and might be useful for expanding mature human primary hepatocytes. In human primary hepatocytes, FPH2 increased the number of nuclei undergoing mitosis and hepatocyte nuclei count in a concentration dependent way. Also, FPH2 (40 μM) increased the area of hepatocyte colonies with more hepatocytes and Ki67-positive nuclei, which exhibited hepatocyte nuclear morphologies. In primary human hepatocytes from six additional cell sources, FPH2 increased hepatocytes expansion. FPH2 increased hepatocyte at a rate that is consistent with liver regeneration kinetics in vivo [1].
Reference:
[1]. Shan J, Schwartz RE, Ross NT, et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nat Chem Biol, 2013, 9(8): 514-520.
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FPH2 induces of functional proliferation of primary human hepatocytes and may lead to the development of new therapeutics for liver diseases.
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