(+)-Fenchone

CAS# 4695-62-9

(+)-Fenchone

Catalog No. BCN9071----Order now to get a substantial discount!

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Chemical structure

(+)-Fenchone

3D structure

Chemical Properties of (+)-Fenchone

Cas No. 4695-62-9 SDF Download SDF
PubChem ID 1201521 Appearance Faintly yellow/green liquid
Formula C10H16O M.Wt 152.24
Type of Compound Monoterpenoids Storage Desiccate at -20°C
Solubility Soluble in ethanol; practically insoluble in water
Chemical Name (1S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-one
SMILES CC1(C2CCC(C2)(C1=O)C)C
Standard InChIKey LHXDLQBQYFFVNW-XCBNKYQSSA-N
Standard InChI InChI=1S/C10H16O/c1-9(2)7-4-5-10(3,6-7)8(9)11/h7H,4-6H2,1-3H3/t7-,10+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of (+)-Fenchone

1 Illicium sp.

(+)-Fenchone Dilution Calculator

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(+)-Fenchone Molarity Calculator

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Preparing Stock Solutions of (+)-Fenchone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 6.5686 mL 32.8429 mL 65.6858 mL 131.3715 mL 164.2144 mL
5 mM 1.3137 mL 6.5686 mL 13.1372 mL 26.2743 mL 32.8429 mL
10 mM 0.6569 mL 3.2843 mL 6.5686 mL 13.1372 mL 16.4214 mL
50 mM 0.1314 mL 0.6569 mL 1.3137 mL 2.6274 mL 3.2843 mL
100 mM 0.0657 mL 0.3284 mL 0.6569 mL 1.3137 mL 1.6421 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on (+)-Fenchone

Bioactivity of some Apiaceae essential oils and their constituents against Sitophilus zeamais (Coleoptera: Curculionidae).[Pubmed:31813390]

Bull Entomol Res. 2020 Jun;110(3):406-416.

Sitophilus zeamais is a key pest of stored grains. Its control is made, usually, using synthetic insecticides, despite their negative impacts. Botanical insecticides with fumigant/repellent properties may offer an alternative solution. This work describes the effects of Anethum graveolens, Petroselinum crispum, Foeniculum vulgare and Cuminum cyminum essential oils (EOs) and (S)-carvone, cuminaldehyde, estragole and (+)-Fenchone towards adults of S. zeamais. Acute toxicity was assessed by fumigation and topical application. Repellence was evaluated by an area preference bioassay and two-choice test, using maize grains. LC50 determined by fumigation ranged from 51.8 to 535.8 mg L-1 air, with (S)-carvone being the most active. LD50 values for topical applications varied from 23 to 128 microg per adult for (S)-carvone > cuminaldehyde > A. graveolens > C. cyminum > P. crispum. All EOs/standard compounds reduced significantly the percentage of insects attracted to maize grains (65-80%) in the two-choice repellence test, whereas in the area preference bioassay RD50 varied from 1.4 to 45.2 microg cm-2, with cuminaldehyde, (S)-carvone and estragole being strongly repellents. Petroselinum crispum EO and cuminaldehyde affected the nutritional parameters relative growth rate, efficiency conversion index of ingested food and antifeeding effect, displaying antinutritional effects toward S. zeamais. In addition, P. crispum and C. cyminum EOs, as well as cuminaldehyde, showed the highest acetylcholinesterase inhibitory activity in vitro (IC50 = 185, 235 and 214.5 microg mL-1, respectively). EOs/standard compounds exhibited acute toxicity, and some treatments showed antinutritional effects towards S. zeamais. Therefore, the tested plant products might be good candidates to be considered to prevent damages caused by this pest.

Triggering of apoptosis and cell cycle arrest by fennel and clove oils in Caco-2 cells: the role of combination.[Pubmed:31364915]

Toxicol Mech Methods. 2019 Nov;29(9):710-722.

Background: Fennel (Foeniculum vulgare) and clove (Syzygium aromaticum) oils are known for their various biological effects, including anticancer properties. Objective: To investigate the anticancer effect of combined fennel and clove oil treatment on Caco-2 cells and normal human lymphocytes (NHL). Methods: GC-MS, in vitro cytotoxicity, morphological, apoptosis-related marker, and flow cytometric cell cycle distribution analyses were conducted. Results: Seventeen volatile compounds were identified in fennel oil, including trans-anethole (68.3%) and (+)-Fenchone (8.1%). In clove oil, 22 compounds, including eugenol (71.4%) and caryophyllene (8.7%), were identified. IC50 of the fennel, clove, and oil mixture were 300 +/- 5.0, 150 +/- 4.0, and 73 +/- 2.5 microg/mL, respectively with combination index (CI) < 1.0. Mechanistic anticancer properties were investigated using 30, 45, and 60 microg/mL oil mixture. Analysis of apoptotic morphology, flow cytometric cell cycle distribution, and apoptosis-related markers, such as Bcl-2 and Ki-67, confirmed cell cycle arrest and apoptosis induction in Caco-2 cells by the fennel and clove oil combination. Moreover, the oil mixture did not exert significant (p < 0.01) toxicity on NHL in vitro. Conclusion: The oil mixture exerted selective cytotoxicity towards Caco-2 cells through cell cycle arrest and apoptosis, which may occur through synergistic effects between fennel and clove oil active ingredients.

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