GB 2a

CAS# 18412-96-9

GB 2a

Catalog No. BCN7425----Order now to get a substantial discount!

Product Name & Size Price Stock
GB 2a: 5mg $725 In Stock
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Quality Control of GB 2a

Number of papers citing our products

Chemical structure

GB 2a

3D structure

Chemical Properties of GB 2a

Cas No. 18412-96-9 SDF Download SDF
PubChem ID 176988 Appearance Powder
Formula C30H22O11 M.Wt 558.49
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2S)-8-[(2S,3R)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-2,3-dihydrochromen-3-yl]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydrochromen-4-one
SMILES C1C(OC2=C(C1=O)C(=CC(=C2C3C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC=C(C=C5)O)O)O)C6=CC(=C(C=C6)O)O
Standard InChIKey IMIXFUXOSFSXPC-DETITRACSA-N
Standard InChI InChI=1S/C30H22O11/c31-14-4-1-12(2-5-14)29-27(28(39)25-18(35)8-15(32)9-23(25)41-29)26-20(37)10-19(36)24-21(38)11-22(40-30(24)26)13-3-6-16(33)17(34)7-13/h1-10,22,27,29,31-37H,11H2/t22-,27-,29+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of GB 2a

The fruits of Garcinia xanthochymus.

Biological Activity of GB 2a

Description1. GB 2a shows antioxidant activity. 2. GB 2a biflavonoid can promote inhibition on tyrosinase activity and reduced melanin biosynthesis in B16F10 cells, which suggests great potential for medical and cosmetic uses as a depigmenting agent. 3. GB 2a has anti-inflammatory effects, it can prevent the carrageenan-induced paw oedema.
TargetsTyrosinase | Immunology & Inflammation related

GB 2a Dilution Calculator

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GB 2a Molarity Calculator

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Preparing Stock Solutions of GB 2a

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7905 mL 8.9527 mL 17.9054 mL 35.8108 mL 44.7636 mL
5 mM 0.3581 mL 1.7905 mL 3.5811 mL 7.1622 mL 8.9527 mL
10 mM 0.1791 mL 0.8953 mL 1.7905 mL 3.5811 mL 4.4764 mL
50 mM 0.0358 mL 0.1791 mL 0.3581 mL 0.7162 mL 0.8953 mL
100 mM 0.0179 mL 0.0895 mL 0.1791 mL 0.3581 mL 0.4476 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on GB 2a

Anti-inflammatory effects of hydroalcoholic extract and two biflavonoids from Garcinia gardneriana leaves in mouse paw oedema.[Pubmed:18555627]

J Ethnopharmacol. 2008 Aug 13;118(3):405-11.

Garcinia gardneriana (Planch. & Triana) Zappi (Clusiaceae) is widely distributed in Brazil and used in folk medicine to treat inflammation, pain, and urinary tract and other infections. However, very few studies have analyzed these therapeutic effects. In this study, the anti-inflammatory effects of the hydroalcoholic extracts from Garcinia gardneriana (HEGG) and some of its isolated biflavonoids were evaluated. The results showed that HEGG from the leaves, bark and seeds reduced carrageenan-induced mouse paw inflammation, in addition to diminishing the myeloperoxidase activity in the stimulated tissues. The reduction of neutrophil infiltration by treatment with the HEGG from leaves was confirmed by histology. The leaf extract also reduced the paw oedema evoked by bradykinin, histamine, prostaglandin E2 and 12-O-tetradecanoylphorbol acetate. However, it partially decreased substance P and compound 48/80-caused paw oedema, without any influence on the arachidonic acid-induced oedema. Both of the isolated compounds, fukugetin and GB-2a, prevented the carrageenan-induced paw oedema. In conclusion, this study showed important anti-inflammatory effects of HEGG through its interaction with different intracellular signaling pathways, without interfering with the formation of arachidonic acid (AA) metabolites. These characteristics, in addition to the wide distribution and culturing ease of the plant, confirm its popular use and highlight its promise in the development of new anti-inflammatory drugs.

Inhibitory effect of GB-2a (I3-naringenin-II8-eriodictyol) on melanogenesis.[Pubmed:26297636]

J Ethnopharmacol. 2015 Nov 4;174:224-9.

ETHNOPHARMACOLOGY RELEVANCE: GB-2a is a I3-naringenin-II8-eriodictyol compound isolated from Garcinia gardneriana (Planchon & Triana) Zappi, a plant used in folk medicine for the treatment of skin disorders. AIM OF STUDY: In the search for new depigmenting agents, this study was carried out to investigate the in vitro effects of GB-2a isolated from G. gardneriana (Planchon & Triana) Zappi in B16F10 melanoma cells. MATERIALS AND METHODS: The effects of GB-2a were evaluated through determination of melanin biosynthesis in B16F10 melanoma cells in comparison with the reference drug kojic acid (500microM). In parallel, the GB-2a effect was assessed in a cell viability assay. Mushroom tyrosinase activity assays were conducted to verify the effect of this enzyme. In order to ascertain the nature of enzyme inhibition on tyrosinase, kinetics analysis of the GB-2a was performed with L-tyrosine and L-3,4-dihydroxyphenylalanine (L-DOPA) substrates. RESULTS: The results showed that GB-2a biflavonoid significantly inhibited the melanin content, without reducing cell viability. GB-2a also showed a strong antityrosinase activity in the mushroom tyrosinase assay. GB-2a inhibited the tyrosinase activity, exerting a mixed inhibition. For the L-tyrosine substrate the inhibition was in non-competitive mode and for L-DOPA it was in uncompetitive mode. CONCLUSION: GB-2a biflavonoid promoted inhibition on tyrosinase activity and reduced melanin biosynthesis in B16F10 cells, which suggests great potential for medical and cosmetic uses as a depigmenting agent.

Using Ultra-Performance Liquid Chromatography Quadrupole Time of Flight Mass Spectrometry-Based Chemometrics for the Identification of Anti-angiogenic Biflavonoids from Edible Garcinia Species.[Pubmed:28926234]

J Agric Food Chem. 2017 Sep 27;65(38):8348-8355.

Garcinia xanthochymus fruits are edible and also used in traditional medicine. Our previous work showed that the isolated natural products from G. xanthochymus fruits have displayed antioxidant activity and cytotoxicity in the colon cancer cells. In this study, we developed a strategy to correlate a zebrafish angiogenesis assay with ultra-performance liquid chromatography quadrupole time of flight mass spectrometry-based chemometric analysis to identify potential anti-angiogenic activity compounds from G. xanthochymus fruits. Primary bioactivity results showed that the methanolic extracts from aril and pericarp but not from seed have significant inhibitory effects on the growth of subintestinal vessels (SIVs) in zebrafish embryos. A total of 13 markers, including benzophenones and biflavonoids, were predicted by untargeted principal component analysis and orthogonal partial least squares discriminate analysis, which were tentatively identified as priority markers for the bioactivity related in aril and pericarp. Amentoflavone, a biflavonoid, has been found to significantly inhibit the growth of SIVs at 10 and 20 muM and downregulate the expressions of Angpt2 and Tie2 genes of zebrafish embryos. Furthermore, seven biflavonoids, volkensiflavone, fukugetin, fukugeside, GB 1a, GB 1a glucoside, GB 2a, and GB 2a glucoside, isolated from Garcinia species were evaluated for their structure-activity relationship using the zebrafish model. Only fukugetin, which was previously shown to be anticancer, was active in inhibiting the SIV growth. In this report, both amentoflavone and fukugetin, for the first time, displayed anti-angiogenic effects on zebrafish, thus demonstrating an effective and rapid strategy to identify natural products for anti-angiogenesis activity.

Polyphenols from Allanblackia floribunda seeds: Identification, quantification and antioxidant activity.[Pubmed:28041556]

Food Chem. 2017 May 1;222:35-42.

Oil rich seeds of Allanblackia floribunda, a tree from tropical Africa, have traditionally been used in food preparation. Furthermore, the therapeutic properties of various parts of this tree have long been exploited in traditional medicine. As both food and pharmaceutical industries show growing interest in tropical tree crops, this study aimed to investigate whether A. floribunda seeds could also be used as a source of potentially bioactive compounds. The polyphenol profile revealed six predominant compounds which were identified by HPLC-PDA-ESI/MS(n) as the biflavonoids morelloflavone, Gb-2a and volkensiflavone and their respective glucosides. A range of less abundant flavones, flavonols and flavan-3-ols was also detected. All six major compounds showed antioxidant activity, with the activity of morelloflavone, its glucoside and Gb-2a-glucoside comparable with that of ascorbic acid. The main compounds accounted for approximately 10% of dry weight, making the seeds used for oil production a rich source of biflavonoids as a by-product.

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