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Homovanillyl alcohol

CAS# 2380-78-1

Homovanillyl alcohol

Catalog No. BCN7173----Order now to get a substantial discount!

Product Name & Size Price Stock
Homovanillyl alcohol: 5mg $58 In Stock
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Quality Control of Homovanillyl alcohol

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Chemical structure

Homovanillyl alcohol

3D structure

Chemical Properties of Homovanillyl alcohol

Cas No. 2380-78-1 SDF Download SDF
PubChem ID 16928 Appearance Oil
Formula C9H12O3 M.Wt 168.19
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 4-(2-hydroxyethyl)-2-methoxyphenol
SMILES COC1=C(C=CC(=C1)CCO)O
Standard InChIKey XHUBSJRBOQIZNI-UHFFFAOYSA-N
Standard InChI InChI=1S/C9H12O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,6,10-11H,4-5H2,1H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Homovanillyl alcohol

The seeds and nettle roots of flax.

Biological Activity of Homovanillyl alcohol

Description1. Homovanillyl alcohol has protective effect on cardiovascular disease and total mortality. 2. Homovanillyl alcohol displays high scavenging activities. 3. Homovanillyl alcohol protects red blood cells from hemolysis in a dose-dependent manner.
TargetsTNF-α

Homovanillyl alcohol Dilution Calculator

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Homovanillyl alcohol Molarity Calculator

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Preparing Stock Solutions of Homovanillyl alcohol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.9457 mL 29.7283 mL 59.4566 mL 118.9131 mL 148.6414 mL
5 mM 1.1891 mL 5.9457 mL 11.8913 mL 23.7826 mL 29.7283 mL
10 mM 0.5946 mL 2.9728 mL 5.9457 mL 11.8913 mL 14.8641 mL
50 mM 0.1189 mL 0.5946 mL 1.1891 mL 2.3783 mL 2.9728 mL
100 mM 0.0595 mL 0.2973 mL 0.5946 mL 1.1891 mL 1.4864 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Homovanillyl alcohol

Protective effect of homovanillyl alcohol on cardiovascular disease and total mortality: virgin olive oil, wine, and catechol-methylathion.[Pubmed:28446500]

Am J Clin Nutr. 2017 Jun;105(6):1297-1304.

Background: Hydroxytyrosol is a phenolic compound that is present in virgin olive oil (VOO) and wine. Hydroxytyrosol-related foods have been shown to protect against cardiovascular disease (CVD).Objective: We investigated the associations between hydroxytyrosol and its biological metabolite, 3-O-methyl-hydroxytyrosol, also known as Homovanillyl alcohol (HVAL), with CVD and total mortality.Design: We included 1851 men and women with a mean +/- SD age of 66.8 +/- 6 y at high risk of CVD from prospective cohort data. The primary endpoint was a composite of myocardial infarction, stroke, and death from cardiovascular causes; the secondary endpoint was all-cause mortality. Twenty-four-hour urinary hydroxytyrosol and HVAL and catechol-O-methyltransferase (COMT) rs4680 genotypes were measured.Results: After multivariable adjustment, all biomarkers were associated, as a continuous variable, with lower CVD risk, but only HVAL showed a strong inverse association (HR: 0.44; 95% CI: 0.25, 0.80) for the comparison between quintiles. Only HVAL, as a continuous variable, was associated with total mortality (HR: 0.81; 95% CI: 0.70, 0.95). Individuals in the highest quintile of HVAL compared with the lowest had 9.2 (95% CI: 3.5, 20.8) and 6.3 (95% CI: 2.3, 12.1) additional years of life or years free of CVD, respectively, after 65 y. Individuals with the rs4680GG genotype had the highest HVAL concentrations (P = 0.05). There was no association between COMT genotypes and events or interaction between COMT genotypes and HVAL concentrations.Conclusions: We report, for the first time to our knowledge, an independent association between high urinary HVAL concentrations and a lower risk of CVD and total mortality in elderly individuals. VOO and wine consumption and a high metabolic COMT capacity for methylation are key factors for high HVAL concentrations. The association that stems from our results reinforces the benefits of 2 key components of the Mediterranean diet (wine and VOO). This trial was registered at www.predimed.es as ISRCTN35739639.

Protective activity of hydroxytyrosol metabolites on erythrocyte oxidative-induced hemolysis.[Pubmed:23777263]

J Agric Food Chem. 2013 Jul 10;61(27):6636-42.

The capacity of important hydroxytyrosol metabolites (Homovanillyl alcohol, hydroxytyrosol acetate, Homovanillyl alcohol acetate, hydroxytyrosol 3' and 4'-O-glucuronides, and Homovanillyl alcohol 4'-O-glucuronide) to protect red blood cells (RBCs) from oxidative injury induced by the radical initiator 2,2'-azo-bis(2-amidinopropane) dihydrochloride (AAPH) or by the natural radical initiator H2O2 was evaluated. In the presence of AAPH, all compounds showed to protect RBCs from hemolysis in a dose-dependent manner, exccept for the Homovanillyl alcohol glucuronide, with the order of activity being at 20 muM hydroxytyrosol > hydroxytyrosol glucuronides = hydroxytyrosol acetate = Homovanillyl alcohol = homovanillyl acetate > Homovanillyl alcohol glucuronide. At 10 muM, hydroxytyrosol, hydroxytyrosol acetate, and hydroxytyrosol glucuronides still protected hemoglobine from oxidation and from morphological RBC changes. In the presence of H2O2, hydroxytyrosol showed to significantly protect RBCs from oxidative hemolysis in a dose-dependent manner, but the hydroxytyrosol glucuronides showed only a limited protection that was independent of the concentration used.

Olive oil phenolic compounds inhibit homocysteine-induced endothelial cell adhesion regardless of their different antioxidant activity.[Pubmed:19358606]

J Agric Food Chem. 2009 May 13;57(9):3478-82.

In this study, we examine the effect of extra virgin olive oil phenolic compounds on homocysteine-induced endothelial dysfunction and whether the protective effects are related to their different scavenging activities. Structurally related compounds have been assayed for their ability to reduce homocysteine-induced monocyte adhesion as well as the cell surface expression of intercellular adhesion molecule-1 (ICAM-1) in EA.hy.926 cells. As well-known, among the selected phenolic compounds, hydroxytyrosol, Homovanillyl alcohol, and the hydroxycinnamic acid derivatives caffeic and ferulic acid display high scavenging activities, while tyrosol and p-coumaric acid are poorly active. All of the tested compounds, approaching potential in vivo concentrations, significantly reduce homocysteine-induced cell adhesion and ICAM-1 expression. Interestingly, we report the first evidence that monophenols tyrosol and p-coumaric acid are selectively protective only in homocysteine-activated cells, while they are ineffective in reducing ICAM-1 expression induced by TNFalpha. Finally, we report the synergistic effect of o-diphenolic and monophenolic compounds.

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