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Liensinine perchlorate

CAS# 2385-63-9

Liensinine perchlorate

Catalog No. BCN6335----Order now to get a substantial discount!

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Liensinine perchlorate: 5mg $81 In Stock
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Quality Control of Liensinine perchlorate

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Chemical structure

Liensinine perchlorate

3D structure

Chemical Properties of Liensinine perchlorate

Cas No. 2385-63-9 SDF Download SDF
PubChem ID 71307566 Appearance White powder
Formula C37H43ClN2O10 M.Wt 711.20
Type of Compound Alkaloids Storage Desiccate at -20°C
Synonyms Liensinine-Perchlorate
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol;perchloric acid
SMILES CN1CCC2=CC(=C(C=C2C1CC3=CC=C(C=C3)O)OC4=C(C=CC(=C4)CC5C6=CC(=C(C=C6CCN5C)OC)OC)O)OC.OCl(=O)(=O)=O
Standard InChIKey SBJXHMBOBQYZFA-XBPPRYKJSA-N
Standard InChI InChI=1S/C37H42N2O6.ClHO4/c1-38-14-13-26-20-35(43-4)37(22-29(26)30(38)16-23-6-9-27(40)10-7-23)45-33-18-24(8-11-32(33)41)17-31-28-21-36(44-5)34(42-3)19-25(28)12-15-39(31)2;2-1(3,4)5/h6-11,18-22,30-31,40-41H,12-17H2,1-5H3;(H,2,3,4,5)/t30-,31-;/m1./s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Liensinine perchlorate

The plantule of Nelumbo nucifera Gaertn.

Biological Activity of Liensinine perchlorate

Description1. Liensinine perchlorate has inhibitory effect on macrophage phagocytosis and macrophage metabolism in mice, suggests that it has immunosuppressive effects.

Liensinine perchlorate Dilution Calculator

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Liensinine perchlorate Molarity Calculator

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Preparing Stock Solutions of Liensinine perchlorate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.4061 mL 7.0304 mL 14.0607 mL 28.1215 mL 35.1519 mL
5 mM 0.2812 mL 1.4061 mL 2.8121 mL 5.6243 mL 7.0304 mL
10 mM 0.1406 mL 0.703 mL 1.4061 mL 2.8121 mL 3.5152 mL
50 mM 0.0281 mL 0.1406 mL 0.2812 mL 0.5624 mL 0.703 mL
100 mM 0.0141 mL 0.0703 mL 0.1406 mL 0.2812 mL 0.3515 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Liensinine perchlorate

Liensinine perchlorate inhibits colorectal cancer tumorigenesis by inducing mitochondrial dysfunction and apoptosis.[Pubmed:30207364]

Food Funct. 2018 Nov 14;9(11):5536-5546.

SCOPE: Colorectal cancer (CRC) is one of the most common cancers worldwide with poor survival and limited therapeutic options, and there is an urgent need to develop novel therapeutic agents with good treatment efficiency and low toxicity. This study aims to examine the anticancer bioactivity of liensinine, a constituent of Nelumbo nucifera Gaertn, in CRC and investigate the action mechanisms involved. METHODS AND RESULTS: Liensinine was found to induce apoptosis and exert a significant inhibitory effect on the proliferation and colony-forming ability of CRC cells in a dose-dependent manner without any observed cytotoxicity on normal colorectal epithelial cells. Mechanistically, our data from quantitative proteomics, western blot analysis and flow cytometry analyses demonstrated that exposure of CRC cells to liensinine caused cell cycle arrest, mitochondrial dysfunction and apoptosis, accompanied by the activation of the JNK signaling pathway. Furthermore, animal experiments showed that liensinine markedly suppressed the growth of CRC tumor xenografts in nude mice by reducing the Ki-67 proliferation index, but did not damage the vital organs of the animals. CONCLUSION: This study demonstrated for the first time that liensinine, a food-source natural product, could be a novel therapeutic strategy for treating CRC without obvious side effects.

Description

Liensinine Perchlorate is a constituent of Nelumbo nucifera Gaertn, with ani-hypertension and anti-cancer activities. Liensinine Perchlorate induces colorectal cancer (CRC) cell apoptosis.

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