HydroxyprogesteroneCAS# 68-96-2 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 68-96-2 | SDF | Download SDF |
| PubChem ID | 6238 | Appearance | Powder |
| Formula | C21H30O3 | M.Wt | 330.5 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | 17α-Hydroxyprogesterone; 17-OHP | ||
| Solubility | DMSO : ≥ 39 mg/mL (118.02 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | (8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one | ||
| SMILES | CC(=O)C1(CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C)O | ||
| Standard InChIKey | DBPWSSGDRRHUNT-CEGNMAFCSA-N | ||
| Standard InChI | InChI=1S/C21H30O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h12,16-18,24H,4-11H2,1-3H3/t16-,17+,18+,19+,20+,21+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Hydroxyprogesterone Dilution Calculator
Hydroxyprogesterone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.0257 mL | 15.1286 mL | 30.2572 mL | 60.5144 mL | 75.643 mL |
| 5 mM | 0.6051 mL | 3.0257 mL | 6.0514 mL | 12.1029 mL | 15.1286 mL |
| 10 mM | 0.3026 mL | 1.5129 mL | 3.0257 mL | 6.0514 mL | 7.5643 mL |
| 50 mM | 0.0605 mL | 0.3026 mL | 0.6051 mL | 1.2103 mL | 1.5129 mL |
| 100 mM | 0.0303 mL | 0.1513 mL | 0.3026 mL | 0.6051 mL | 0.7564 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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17-Hydroxyprogesterone (17-OHP) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.
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Hypothalamic-Pituitary-Gonadal Activity in Paradoxical and Psychophysiological Insomnia.[Pubmed:30967991]
J Med Signals Sens. 2019 Jan-Mar;9(1):59-67.
Background: Although insomnia is a sex-dimorphic disorder, there is limited knowledge about the association between sex hormones and insomnia. In the present study, the level of hypothalamus-pituitary-gonadal (HPG) axis activity was investigated in patients with insomnia by measuring serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), 17alpha-Hydroxyprogesterone, testosterone, progesterone, estradiol, dehydroepiandrosterone sulfate, and sex hormone-binding globulin. Methods: Numbers of 19 patients; including 13 females (68.40%) with paradox insomnia (32-53 years; 43.20 +/- 6.40) and 17 patients; including 8 females (47.05%) with psychophysiological insomnia (14-62 years; 38.40 +/- 16.30) were recruited. Seventeen aged-matched normal sleeper consisted of 13 males (26-59 years; 40.70 +/- 10) consisted of 13 males (76.50%) were also recruited as control group. Insomnia was diagnosed by a sleep clinician according to the International Classification of Sleep Disorders-Second Edition criteria and an overnight polysomnography (PSG). A volume of 5 ml of venous blood samples were collected, prepared, and stored at 8 AM under standard condition. Serum levels of hormones were measured using enzyme-linked immunosorbent assay kits. Data were analyzed by Chi-square and ANCOVA. The associations between PSG and biochemical parameters were evaluated using multiple linear regression analysis. Results: There were no significant differences in all biochemical analyses between two insomnia subgroups (paradoxical and psychophysiological insomnia) and normal sleepers. Testosterone was positively related to maximum pulse transit time (PTT). Moreover, both LH and FSH were positively related to wake index and diastolic blood pressure. Conclusion: Although there were no significant differences in all HPG's hormones between groups, both LH and FSH were associated with wake index and diastolic blood pressure. Moreover, testosterone was positively related to PTT.
Individual 17-Hydroxyprogesterone Responses to hCG Are Not Correlated With Follicle Size in Polycystic Ovary Syndrome.[Pubmed:30918916]
J Endocr Soc. 2019 Feb 7;3(4):687-698.
Context: In women with polycystic ovary syndrome (PCOS), 17-Hydroxyprogesterone (17-OHP) responses to gonadotropin stimulation vary from increased to indistinguishable compared with normal controls. Objective: To determine whether 17-OHP responses to recombinant-human chorionic gonadotropin (r-hCG) are individually correlated to the size of antral follicles among women with PCOS. Design Setting and Participants: A prospective study conducted in 19 women with PCOS and 20 normal controls at an academic medical center. Interventions: Blood samples were obtained before and 24 hours after administration of 25 mug of r-hCG. Ovarian imaging was conducted with three-dimensional pelvic ultrasonography. Each subject underwent a 2-hour oral glucose tolerance test. Main Outcome Measures: Basal and stimulated levels of 17-OHP, androgens, estradiol, progesterone, anti-Mullerian hormone (AMH), insulin, glucose, follicle number, and size. Results: In women with PCOS, mean antral follicle count (AFC) was greater than that of controls, although the size of cohort follicles within individual subjects was not correlated to 17-OHP responses. The numbers of 2- to 3-mm and 3- to 4-mm follicles in PCOS were significantly greater than in controls, whereas differences between larger follicles were not observed. Increased AMH in PCOS was correlated to AFC, but not 17-OHP responses. Insulin sensitivity did not correlate to r-hCGstimulated 17-OHP after adjustment for body mass index. Conclusions: 17-OHP responses to hCG in individuals with PCOS were not correlated to the distribution of antral follicles. Greater numbers of small antral follicles in women with PCOS than in controls suggest an extension of accelerated growth from the preantral stage.
