HyperforinCAS# 11079-53-1 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 11079-53-1 | SDF | Download SDF |
PubChem ID | 441298 | Appearance | Powder |
Formula | C35H52O4 | M.Wt | 536.80 |
Type of Compound | Miscellaneous | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | (1R,5R,7S,8R)-4-hydroxy-8-methyl-3,5,7-tris(3-methylbut-2-enyl)-8-(4-methylpent-3-enyl)-1-(2-methylpropanoyl)bicyclo[3.3.1]non-3-ene-2,9-dione | ||
SMILES | CC(C)C(=O)C12C(=O)C(=C(C(C1=O)(CC(C2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C | ||
Standard InChIKey | KGSZHKRKHXOAMG-HQKKAZOISA-N | ||
Standard InChI | InChI=1S/C35H52O4/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10/h13-15,18,26-27,37H,12,16-17,19-21H2,1-11H3/t27-,33+,34+,35-/m0/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | Hyperforin acts as an angiogenesis inhibitor, it as a possible antidepressant component of hypericum extracts. Hyperforin acts as a dual inhibitor of 5-LO and COX-1 in intact cells as well as on the catalytic activity of the crude enzymes, suggesting therapeutic potential in inflammatory and allergic diseases connected to eicosanoids. |
Targets | COX-1 | 5-LO | 5-HT recepter | GABA recepter |
In vitro | Hyperforin as a possible antidepressant component of hypericum extracts.[Pubmed: 9718074 ]Life Sci. 1998;63(6):499-510.
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Kinase Assay | Hyperforin acts as an angiogenesis inhibitor.[Pubmed: 16320199]Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase.[Pubmed: 12445866 ]Biochem Pharmacol. 2002 Dec 15;64(12):1767-75.The acylphloroglucinol derivative Hyperforin is the major lipophilic constituent in the herb Hypericum perforatum (St. John's wort). The aim of the present study was to investigate if Hyperforin as well as extracts of H. perforatum can suppresses the activities of 5-lipoxygenase (5-LO) and cyclooxygenases (COX), key enzymes in the formation of proinflammatory eicosanoids from arachidonic acid (AA). Planta Med. 2005 Nov;71(11):999-1004.Hyperforin is a plant compound from Hypericum perforatum that inhibits tumor cell proliferation in vitro by induction of apoptosis. Here, we report that Hyperforin also acts as an angiogenesis inhibitor in vitro and in vivo. |
Hyperforin Dilution Calculator
Hyperforin Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 1.8629 mL | 9.3145 mL | 18.6289 mL | 37.2578 mL | 46.5723 mL |
5 mM | 0.3726 mL | 1.8629 mL | 3.7258 mL | 7.4516 mL | 9.3145 mL |
10 mM | 0.1863 mL | 0.9314 mL | 1.8629 mL | 3.7258 mL | 4.6572 mL |
50 mM | 0.0373 mL | 0.1863 mL | 0.3726 mL | 0.7452 mL | 0.9314 mL |
100 mM | 0.0186 mL | 0.0931 mL | 0.1863 mL | 0.3726 mL | 0.4657 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
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